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Chemical Compound Review: 

DIZOCILPINE    

Synonyms: Neurogard, Dizocilpina, Dizocilpinum, MK-801, SureCN2259890, ...
 
 
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Chemical compound and disease context of DIZOCILPINE

  • The ability of clozapine to block excessive cortical 5-HT efflux elicited by MK-801 might be related to the superior efficacy of this drug in treating negative/cognitive symptoms of schizophrenia [1].

References

  1. Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat. López-Gil, X., Babot, Z., Amargós-Bosch, M., Suñol, C., Artigas, F., Adell, A. Neuropsychopharmacology (2007) [Pubmed]
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