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Chemical Compound Review


Synonyms: Clorazil, Clozapin, Klozapol, Asaleptin, Azaleptin, ...
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Disease relevance of CLOZARIL


Associations of CLOZARIL with other chemical compounds

  • Clozapine and DMClz but not haloperidol had an activity-dependent influence on spontaneous firing rate of PFC cells: they increased the activity of neurons with low baseline firing rates and decreased the activity of neurons with higher firing rates [3].
  • In normal monkeys, clozapine elevated dopamine turnover in all prefrontal cortical, but not subcortical, regions analyzed [4].


  1. Association of initial antipsychotic response to clozapine and long-term weight gain. Bai, Y.M., Lin, C.C., Chen, J.Y., Lin, C.Y., Su, T.P., Chou, P. Am. J. Psychiatry (2006) [Pubmed]
  2. Clozapine underutilization and discontinuation in African Americans due to leucopenia. Kelly, D.L., Kreyenbuhl, J., Dixon, L., Love, R.C., Medoff, D., Conley, R.R. Schizophr. Bull (2007) [Pubmed]
  3. Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine. Homayoun, H., Moghaddam, B. Biol. Psychiatry (2007) [Pubmed]
  4. Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Elsworth, J.D., Jentsch, J.D., Morrow, B.A., Redmond, D.E., Roth, R.H. Neuropsychopharmacology (2008) [Pubmed]
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