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Chemical Compound Review:

CLOZARIL

Synonyms: Clorazil, Clozapin, Klozapol, Asaleptin, Azaleptin, ...

Homayoun, H. et al., Bai, Y.M. et al., Elsworth, J.D. et al., Kelly, D.L. et al.

Robert R. Conley, Deborah Medoff, Raymond C. Love, Lisa Dixon, Deanna L. Kelly, John D. Elsworth, J. David Jentsch, Bret A. Morrow, D. Eugene Redmond, Robert H. Roth, Julie Kreyenbuhl,

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Disease relevance of CLOZARIL

The results show that initial antipsychotic response to clozapine is associated with subsequent long-term weight gain as measured over 8 years [1].
It is likely that African Americans had clozapine discontinued unnecessarily due to benign ethnic neutropenia [2].

Associations of CLOZARIL with other chemical compounds

Clozapine and DMClz but not haloperidol had an activity-dependent influence on spontaneous firing rate of PFC cells: they increased the activity of neurons with low baseline firing rates and decreased the activity of neurons with higher firing rates [3].
In normal monkeys, clozapine elevated dopamine turnover in all prefrontal cortical, but not subcortical, regions analyzed [4].

References

Association of initial antipsychotic response to clozapine and long-term weight gain. Bai, Y.M., Lin, C.C., Chen, J.Y., Lin, C.Y., Su, T.P., Chou, P. Am. J. Psychiatry (2006) [Pubmed]
Clozapine underutilization and discontinuation in African Americans due to leucopenia. Kelly, D.L., Kreyenbuhl, J., Dixon, L., Love, R.C., Medoff, D., Conley, R.R. Schizophr. Bull (2007) [Pubmed]
Fine-tuning of awake prefrontal cortex neurons by clozapine: comparison with haloperidol and N-desmethylclozapine. Homayoun, H., Moghaddam, B. Biol. Psychiatry (2007) [Pubmed]
Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine. Elsworth, J.D., Jentsch, J.D., Morrow, B.A., Redmond, D.E., Roth, R.H. Neuropsychopharmacology (2008) [Pubmed]

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