Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

FUTP [[[(2R,3S,4R)-5-(5-fluoro- 2,4-dioxo...

Synonyms: AC1L3TWG, AR-1G8240, AC1Q6S2N, 5-fluorouridine 5'-triphosphate

Lutz, N.W. et al., Chouini-Lalanne, N. et al.

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High impact information on 3828-96-4

The main pathway of 5FC metabolism in the two species of Aspergillus studied is thus the biotransformation into ribofluoronucleotides and the subsequent incorporation of 5-fluorouridine-5'-triphosphate into RNA [1].
Fluoropyrimidine chemotherapy relies on the intracellular anabolic conversion of 5-fluorouracil and the corresponding nucleosides to cytotoxic fluorinated nucleotides (F-Nuctd), such as 5-fluorouridine-5'-triphosphate (FUTP) or 5-fluoro-2'-deoxyuridine-5'-monophosphate (FdUMP), which can be detected by 19F-NMR spectroscopy [2].

References

Study of the metabolism of flucytosine in Aspergillus species by 19F nuclear magnetic resonance spectroscopy. Chouini-Lalanne, N., Malet-Martino, M.C., Martino, R., Michel, G. Antimicrob. Agents Chemother. (1989) [Pubmed]
Assignment and pH dependence of the 19F-NMR resonances from the fluorouracil anabolites involved in fluoropyrimidine chemotherapy. Lutz, N.W., Hull, W.E. NMR in biomedicine. (1999) [Pubmed]

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