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Chemical Compound Review:

AG-D-77427 difluorosilane

Synonyms: AC1L3WCO, CTK4C1162, 13824-36-7, 13966-66-0, Silicon difluoride, ...

Vieira, A. et al., Kim, J. et al., Eisinger, J. et al., Kim, J. et al.

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High impact information on difluorosilane

Hydrolysis of a difluorosilane intermediate to the silanediol leads cleanly to a monomeric product [1].
This study evaluated the in vitro effect of a single professional application of 4% titanium tetrafluoride (TiF4), 1% amine fluoride (AmF) and 0.1% difluorosilane varnish (FV) in preventing wear due to combined erosion and brushing abrasion [2].
Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study [3].

Associations of difluorosilane with other chemical compounds

The silanediol was prepared in high purity by hydrolysis of a difluorosilane intermediate and proved to be an effective inhibitor, differing from the phosphinate by a factor of 4 (K(i)=41nM) [4].

References

A silanediol inhibitor of the metalloprotease thermolysin: synthesis and comparison with a phosphinic acid inhibitor. Kim, J., Sieburth, S.M. J. Org. Chem. (2004) [Pubmed]
Brushing abrasion of eroded bovine enamel pretreated with topical fluorides. Vieira, A., Lugtenborg, M., Ruben, J.L., Huysmans, M.C. Caries Res. (2006) [Pubmed]
Effects of silicon, fluoride, etidronate and magnesium on bone mineral density: a retrospective study. Eisinger, J., Clairet, D. Magnesium research : official organ of the International Society for the Development of Research on Magnesium. (1993) [Pubmed]
Silanediol-based inhibitor of thermolysin. Kim, J., Glekas, A., McN Sieburth, S. Bioorg. Med. Chem. Lett. (2002) [Pubmed]

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