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Chemical Compound Review

Titanium-45     titanium

Synonyms: AC1L4ZAV, 45Ti, 14392-00-8, Titanium, isotope of mass 45
 
 
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Disease relevance of titanium

 

Psychiatry related information on titanium

 

High impact information on titanium

 

Chemical compound and disease context of titanium

 

Biological context of titanium

  • Expanding the scope of asymmetric electrophilic atom-transfer reactions: titanium- and ruthenium-catalyzed hydroxylation of beta-ketoesters [20].
  • The titanium complex diethoxybis-(1-phenylbutane-1,3-dionato)-tita-++ +nium(IV) showed dose-dependent inhibition of cell proliferation, while no significant DNA damage could be detected with the alkaline elution technique [21].
  • Low protein intake is associated with impaired titanium implant osseointegration [22].
  • Bilateral titanium bone chambers were inserted in 70 rats, and side comparisons for bone formation in the chambers were done [23].
  • In this study, 30 skeletally mature beagles (1-2 or 10-12 years old) had titanium implants placed bilaterally in the proximal humerus for a period of 4 weeks in a model of intramembranous bone regeneration [24].
 

Anatomical context of titanium

  • Rat bone marrow stromal cells were seeded in 3D porous titanium fiber mesh scaffolds and cultured for 16 days in a flow perfusion bioreactor with perfusing culture media of different viscosities while maintaining the fluid flow rate constant [25].
  • METHODS AND RESULTS: A series of experiments were performed using 0.20-mm-diameter titanium wires that were impregnated with varying low concentrations of 32P (activity range, 0.002 to 0.06 microCi/cm wire, n = 47) or 31P (nonradioactive control, n = 28) in cultures of rat and human aortic SMCs and in cultured bovine aortic endothelial cells [26].
  • In an attempt to lower the shock strength needed for defibrillation, we designed two large titanium defibrillation patch electrodes that were contoured to fit over the right and left ventricles of the dog heart, covering areas of approximately 33 and 39 cm2, respectively [27].
  • METHODS AND RESULTS: Fourteen titanium-mesh stents were implanted in the iliac arteries of nine NIH miniature swine [28].
  • METHODS AND RESULTS: A tubular epicardial braided carbon electrode of 7F diameter and 14-cm length applied in a U-shape to the epicardium was compared with a standard left ventricular epicardial 15-cm2 titanium mesh patch (CPI Inc) [29].
 

Associations of titanium with other chemical compounds

  • In an attempt to mimic crocidolite-induced cytotoxicity, P388D1 cells or primary elicited macrophages were exposed to the nontoxic mineral particle titanium dioxide in the presence and absence of ferric chloride [30].
  • SEM of the polystyrene culture displayed a porous structure consisting of fibrous and globular components, whereas the titanium tissue culture appeared to be uniformly solid [31].
  • COX-2 and prostaglandin E2 (PGE2) production increased in the calvaria and inflammatory tissue overlying it after Ti implantation [32].
  • Structure-activity correlation in titanium single-site olefin polymerization catalysts containing mixed cyclopentadienyl/aryloxide ligation [33].
  • Heterocycle-fused titanium indenyl silylamido dimethyl complexes produce very high molecular weight polypropylene having a prevailingly syndiotactic microstructure with syndiotactic pentad contents rrrr up to 40-55% (sam-PP) [34].
 

Gene context of titanium

 

Analytical, diagnostic and therapeutic context of titanium

References

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  17. The bisphosphonate ibandronate improves implant integration in osteopenic ovariectomized rats. Kurth, A.H., Eberhardt, C., Müller, S., Steinacker, M., Schwarz, M., Bauss, F. Bone (2005) [Pubmed]
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  21. New platinum, titanium, and ruthenium complexes with different patterns of DNA damage in rat ovarian tumor cells. Frühauf, S., Zeller, W.J. Cancer Res. (1991) [Pubmed]
  22. Low protein intake is associated with impaired titanium implant osseointegration. Dayer, R., Rizzoli, R., Kaelin, A., Ammann, P. J. Bone Miner. Res. (2006) [Pubmed]
  23. The bone morphogenetic proteins antagonist Noggin inhibits membranous ossification. Aspenberg, P., Jeppsson, C., Economides, A.N. J. Bone Miner. Res. (2001) [Pubmed]
  24. Aging does not lessen the effectiveness of TGFbeta2-enhanced bone regeneration. Sumner, D.R., Turner, T.M., Cohen, M., Losavio, P., Urban, R.M., Nichols, E.H., McPherson, J.M. J. Bone Miner. Res. (2003) [Pubmed]
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  26. Low-dose, beta-particle emission from 'stent' wire results in complete, localized inhibition of smooth muscle cell proliferation. Fischell, T.A., Kharma, B.K., Fischell, D.R., Loges, P.G., Coffey, C.W., Duggan, D.M., Naftilan, A.J. Circulation (1994) [Pubmed]
  27. Improved defibrillation thresholds with large contoured epicardial electrodes and biphasic waveforms. Dixon, E.G., Tang, A.S., Wolf, P.D., Meador, J.T., Fine, M.J., Calfee, R.V., Ideker, R.E. Circulation (1987) [Pubmed]
  28. Inhibition of neointimal proliferation with low-dose irradiation from a beta-particle-emitting stent. Laird, J.R., Carter, A.J., Kufs, W.M., Hoopes, T.G., Farb, A., Nott, S.H., Fischell, R.E., Fischell, D.R., Virmani, R., Fischell, T.A. Circulation (1996) [Pubmed]
  29. Improved defibrillation threshold with a new epicardial carbon electrode compared with a standard epicardial titanium patch. Alt, E.U., Fotuhi, P.C., Callihan, R.L., Rollins, D.L., Mestre, E., Combs, M.P., Smith, W.M., Ideker, R.E. Circulation (1995) [Pubmed]
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  31. Osteoblasts generate harder, stiffer, and more delamination-resistant mineralized tissue on titanium than on polystyrene, associated with distinct tissue micro- and ultrastructure. Saruwatari, L., Aita, H., Butz, F., Nakamura, H.K., Ouyang, J., Yang, Y., Chiou, W.A., Ogawa, T. J. Bone Miner. Res. (2005) [Pubmed]
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  36. Fibroblasts express RANKL and support osteoclastogenesis in a COX-2-dependent manner after stimulation with titanium particles. Wei, X., Zhang, X., Zuscik, M.J., Drissi, M.H., Schwarz, E.M., O'Keefe, R.J. J. Bone Miner. Res. (2005) [Pubmed]
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