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Chemical Compound Review

C12111     (6R)-N-[(1R,2S,6S)-2-hydroxy- 2-[6-[(2...

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High impact information on C12111

  • Moreover, TGFbeta1-evoked increases in phosphorylation of SMAD2 were reduced by manumycin-A, suggesting that Ras-dependent transduction cascades activated by TGFbeta1 feed back onto SMAD signaling [1].
  • When parallel experiments were performed with manumycin-A, a Ras farnensyltransferase inhibitor, almost identical inhibitory effects on Fas downstream signaling were exhibited [2].
  • The Ras farnesyl transferase inhibitor manumycin-A, and a dominant-negative form of Ras (RasN17) block the circadian rhythms in CNGC gating, as well as the effects of cAMP [3].


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