Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

C12111 (6R)-N-[(1R,2S,6S)-2-hydroxy- 2-[6-[(2...

Synonyms:

Lhuillier, L. et al., Shin, I. et al., Ko, G.Y. et al.

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High impact information on C12111

Moreover, TGFbeta1-evoked increases in phosphorylation of SMAD2 were reduced by manumycin-A, suggesting that Ras-dependent transduction cascades activated by TGFbeta1 feed back onto SMAD signaling [1].
When parallel experiments were performed with manumycin-A, a Ras farnensyltransferase inhibitor, almost identical inhibitory effects on Fas downstream signaling were exhibited [2].
The Ras farnesyl transferase inhibitor manumycin-A, and a dominant-negative form of Ras (RasN17) block the circadian rhythms in CNGC gating, as well as the effects of cAMP [3].

References

Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons. Lhuillier, L., Dryer, S.E. Brain Res. (2003) [Pubmed]
Ras GTPase is essential for fas-mediated activation of phospholipase D in A20 cells. Shin, I., Han, J.S. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
Circadian regulation of cGMP-gated channels of vertebrate cone photoreceptors: role of cAMP and Ras. Ko, G.Y., Ko, M.L., Dryer, S.E. J. Neurosci. (2004) [Pubmed]

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