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Gene Review

SMAD2  -  SMAD family member 2

Gallus gallus

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High impact information on SMAD2


Biological context of SMAD2

  • Moreover, TGFbeta1-evoked increases in phosphorylation of SMAD2 were reduced by manumycin-A, suggesting that Ras-dependent transduction cascades activated by TGFbeta1 feed back onto SMAD signaling [3].

Associations of SMAD2 with chemical compounds

  • Smad2 RNA injection leads to ectopic expression of XFD-4'. Since activation is also observed in activin A treated animal cap explants in the presence of cycloheximide, XFD-4/4' genes represent direct targets of activin signaling [4].

Other interactions of SMAD2

  • Aza-treated ACs displayed less Smad2 and 3 and increased Smad1, 5, and Smurf2 protein and showed a loss of TGF-beta signaling on the P3TP-luciferase reporter [5].
  • Suggesting that Aza-induction of Smurf2 may be responsible for the loss of Smad2 and 3 protein via this pathway, immunoprecipitation and metabolic labeling experiments confirmed that Aza accelerated the ubiquitination and degradation of these targets [5].


  1. The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord. Liu, J.P. Development (2006) [Pubmed]
  2. Activin a signaling induces Smad2, but not Smad3, requiring protein kinase a activity in granulosa cells from the avian ovary. Schmierer, B., Schuster, M.K., Shkumatava, A., Kuchler, K. J. Biol. Chem. (2003) [Pubmed]
  3. Ras is a mediator of TGFbeta1 signaling in developing chick ciliary ganglion neurons. Lhuillier, L., Dryer, S.E. Brain Res. (2003) [Pubmed]
  4. Activin A signaling directly activates Xenopus winged helix factors XFD-4/4', the orthologues to mammalian MFH-1. Köster, M., Dillinger, K., Knöchel, W. Dev. Genes Evol. (2000) [Pubmed]
  5. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. Zuscik, M.J., Baden, J.F., Wu, Q., Sheu, T.J., Schwarz, E.M., Drissi, H., O'Keefe, R.J., Puzas, J.E., Rosier, R.N. J. Cell. Biochem. (2004) [Pubmed]
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