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Chemical Compound Review:

AC1L3Z74 10-[2-(1-methyl-1-oxido- 3,4,5,6-tetrahydro...

Synonyms: 103827-30-1, Thioridazine N-oxide

Blake, B.L. et al., Watkins, G.M. et al.

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High impact information on Thioridazine N-oxide

4. FMO purified from mouse liver produced thioridazine-N-oxide as the major metabolite [1].
Inactivation of FMO by heat-treatment reduced the formation of thioridazine-N-oxide and northioridazine, whereas inactivation of P450 resulted in decreased amounts of thioridazine-2-sulphoxide, northioridazine, and thioridazine-5-sulphoxide [1].
Phenobarbital induction resulted in increased formation of all metabolites except thioridazine-N-oxide, while retaining a general metabolic profile similar to that achieved with control microsomes [1].
Thioridazine-5-sulphoxide, N-desmethylthioridazine-5-sulphoxide and thioridazine-N-oxide diastereoisomers were found to be thioridazine metabolites following dosing in rats or after in-vitro incubation with rat liver homogenate [2].

References

Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase. Blake, B.L., Rose, R.L., Mailman, R.B., Levi, P.E., Hodgson, E. Xenobiotica (1995) [Pubmed]
Chromatographic separation of thioridazine sulphoxide and N-oxide diastereoisomers: identification as metabolites in the rat. Watkins, G.M., Whelpton, R., Buckley, D.G., Curry, S.H. J. Pharm. Pharmacol. (1986) [Pubmed]

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