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Chemical Compound Review

Aldazine     10-[2-(1-methyl-2- piperidyl)ethyl]-2...

Synonyms: Mellaril, Melleril, Melleryl, Thiozine, Meleril, ...
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Disease relevance of thioridazine


Psychiatry related information on thioridazine


High impact information on thioridazine


Chemical compound and disease context of thioridazine


Biological context of thioridazine


Anatomical context of thioridazine


Associations of thioridazine with other chemical compounds


Gene context of thioridazine


Analytical, diagnostic and therapeutic context of thioridazine


  1. Thioridazine-induced torsade de pointes. Successful therapy with isoproterenol. Kemper, A.J., Dunlap, R., Pietro, D.A. JAMA (1983) [Pubmed]
  2. Letter: Acute hypotension from thioridazine. Kumar, B.B. JAMA (1975) [Pubmed]
  3. High- and low-potency neuroleptics in elderly psychiatric patients. Branchey, M.H., Lee, J.H., Amin, R., Simpson, G.M. JAMA (1978) [Pubmed]
  4. Successful suicides with thioridazine and mesoridazine: a result of probable cardiotoxicity. Donlon, P.T., Tupin, J.P. Arch. Gen. Psychiatry (1977) [Pubmed]
  5. Letter: Water intoxication and thioridazine. Fischman, C.M. Ann. Intern. Med. (1975) [Pubmed]
  6. Comparative effects of methylphenidate and thioridazine in hyperkinetic children. I. Clinical results. Gittelman-Klein, R., Klein, D.F., Katz, S., Saraf, K., Pollack, E. Arch. Gen. Psychiatry (1976) [Pubmed]
  7. Efficacy of antipsychotic medications in behaviorally disturbed dementia patients. Barnes, R., Veith, R., Okimoto, J., Raskind, M., Gumbrecht, G. The American journal of psychiatry. (1982) [Pubmed]
  8. Interaction of mescaline with phenothiazines: effect on behavior, body temperature, and tissue levels of hallucinogen in mice. Shah, N.S., Jacobs, J.R., Jones, J.T., Hedden, M.P. Biol. Psychiatry (1975) [Pubmed]
  9. Prolactin and psychophysiologic measures after single doses of thioridazine. Nikitopoulou, G., Thorner, M., Crammer, J., Lader, M. Clin. Pharmacol. Ther. (1977) [Pubmed]
  10. Mesoridazine and thioridazine: clinical effects and blood levels in refractory schizophrenics. Vital-Herne, J., Gerbino, L., Kay, S.R., Katz, I.R., Opler, L.A. The Journal of clinical psychiatry. (1986) [Pubmed]
  11. Circumvention of multiple-drug resistance in human cancer cells by thioridazine, trifluoperazine, and chlorpromazine. Akiyama, S., Shiraishi, N., Kuratomi, Y., Nakagawa, M., Kuwano, M. J. Natl. Cancer Inst. (1986) [Pubmed]
  12. Thioridazine: a radiation enhancer in advanced cervical cancer? Hercbergs, A. Lancet (1988) [Pubmed]
  13. Prolactin responses to neuroleptics in normal and schizophrenic subjects. Gruen, P.H., Sachar, E.J., Langer, G., Altman, N., Leifer, M., Frantz, A., Halpern, F.S. Arch. Gen. Psychiatry (1978) [Pubmed]
  14. Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine. Strobl, J.S., Kirkwood, K.L., Lantz, T.K., Lewine, M.A., Peterson, V.A., Worley, J.F. Cancer Res. (1990) [Pubmed]
  15. Water intoxication and thioridazine (Mellaril). Rao, K.J., Miller, M., Moses, A. Ann. Intern. Med. (1975) [Pubmed]
  16. Interactions between thioridazine and bromocriptine in a patient with a prolactin-secreting pituitary adenoma. Robbins, R.J., Kern, P.A., Thompson, T.L. Am. J. Med. (1984) [Pubmed]
  17. New data on lithium and haloperidol incompatibility. Spring, G., Frankel, M. The American journal of psychiatry. (1981) [Pubmed]
  18. Paradoxical response to dopamine agonists in tardive dyskinesia. Carroll, B.J., Curtis, G.C., Kokmen, E. The American journal of psychiatry. (1977) [Pubmed]
  19. Haloperidol versus thioridazine in the treatment of behavioral symptoms in senile dementia of the Alzheimer's type: preliminary findings. Steele, C., Lucas, M.J., Tune, L. The Journal of clinical psychiatry. (1986) [Pubmed]
  20. Sensitization to thioridazine through sexual intercourse. Sell, M.B. The American journal of psychiatry. (1985) [Pubmed]
  21. Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype. von Bahr, C., Movin, G., Nordin, C., Lidén, A., Hammarlund-Udenaes, M., Hedberg, A., Ring, H., Sjöqvist, F. Clin. Pharmacol. Ther. (1991) [Pubmed]
  22. Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin. Eap, C.B., Guentert, T.W., Schãublin-Loidl, M., Stabl, M., Koeb, L., Powell, K., Baumann, P. Clin. Pharmacol. Ther. (1996) [Pubmed]
  23. Thioridazine and the neuroleptic radioreceptor assay. Mailman, R.B., Pierce, J.P., Crofton, K.M., Petitto, J., DeHaven, D.L., Kilts, C.D., Lewis, M.H. Biol. Psychiatry (1984) [Pubmed]
  24. Calcium channel blockade: possible explanation for thioridazine's peripheral side effects. Gould, R.J., Murphy, K.M., Reynolds, I.J., Snyder, S.H. The American journal of psychiatry. (1984) [Pubmed]
  25. Thioridazine enhances lysosomal accumulation of epidermal growth factor and toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin. Kuratomi, Y., Akiyama, S., Ono, M., Shiraishi, N., Shimada, T., Ohkuma, S., Kuwano, M. Exp. Cell Res. (1986) [Pubmed]
  26. Thioridazine: central dopamine turnover and clinical effects of antipsychotic drugs. Bowers, M.B. Clin. Pharmacol. Ther. (1975) [Pubmed]
  27. Ca2+ transport by the synaptosomal plasma membrane Ca2+-ATPase and the effect of thioridazine. Palacios, J., Sepúlveda, M.R., Lee, A.G., Mata, A.M. Biochemistry (2004) [Pubmed]
  28. Thioridazine stimulates prolactin secretion in man. Sachar, E.J., Gruen, P.H., Karasu, T.B., Altman, N., Frantz, A.G. Arch. Gen. Psychiatry (1975) [Pubmed]
  29. Withdrawal of haloperidol, thioridazine, and lorazepam in the nursing home: a controlled, double-blind study. Cohen-Mansfield, J., Lipson, S., Werner, P., Billig, N., Taylor, L., Woosley, R. Arch. Intern. Med. (1999) [Pubmed]
  30. Interaction between phenobarbital and thioridazine. Gay, P.E., Madsen, J.A. Neurology (1983) [Pubmed]
  31. QTc interval, CYP2D6 and CYP2C9 genotypes and risperidone plasma concentrations. Llerena, A., Berecz, R., Dorado, P., de la Rubia, A. J. Psychopharmacol. (Oxford) (2004) [Pubmed]
  32. Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine. Wójcikowski, J., Maurel, P., Daniel, W.A. Drug Metab. Dispos. (2006) [Pubmed]
  33. Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients. Yukawa, E., Hokazono, T., Yukawa, M., Ichimaru, R., Maki, T., Matsunaga, K., Ohdo, S., Anai, M., Higuchi, S., Goto, Y. Clinical pharmacokinetics. (2002) [Pubmed]
  34. Effects of typical and atypical antipsychotics on human glycine transporters. Williams, J.B., Mallorga, P.J., Jeffrey Conn, P., Pettibone, D.J., Sur, C. Schizophr. Res. (2004) [Pubmed]
  35. Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans. Hartigan-Go, K., Bateman, D.N., Nyberg, G., Mårtensson, E., Thomas, S.H. Clin. Pharmacol. Ther. (1996) [Pubmed]
  36. Comparative symptomatological and evoked potential studies with d-amphetamine, thioridazine, and placebo in hyperkinetic children. Saletu, B., Saletu, M., Simeon, J., Viamontes, G., Itil, T.M. Biol. Psychiatry (1975) [Pubmed]
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