Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

KST-1A9277 (2R,3S)-2-methylbutane- 1,2,3,4-tetrol

Synonyms: AC1L2NZK, AR-1A2942, AC1Q77RX, 93921-83-6, 2-Methylerythritol, ...

Schkolnik, G. et al., Takahashi, S. et al., Rohdich, F. et al.

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Disease relevance of 2-C-Methylerythritol

We show that an enzyme isolated from cell extract of Escherichia coli converts 2-C-methylerythritol 4-phosphate into 4-diphosphocytidyl-2-C-methylerythritol by reaction with CTP [1].

High impact information on 2-C-Methylerythritol

To clone the gene(s) responsible for synthesis of 2-C-methyl-D-erythritol 4-phosphate, we prepared and selected E. coli mutants with an obligatory requirement for 2-C-methylerythritol for growth and survival [2].
In this study, we have developed a new chromatographic method for the determination of levoglucosan (a specific tracer for biomass burning particles), related polyhydroxy compounds, and 2-methylerythritol (recently identified as isoprene oxidation product in fine aerosols in the Amazon) in smoke and in rainwater samples [3].

References

Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol. Rohdich, F., Wungsintaweekul, J., Fellermeier, M., Sagner, S., Herz, S., Kis, K., Eisenreich, W., Bacher, A., Zenk, M.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Takahashi, S., Kuzuyama, T., Watanabe, H., Seto, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
New analytical method for the determination of levoglucosan, polyhydroxy compounds, and 2-methylerythritol and its application to smoke and rainwater samples. Schkolnik, G., Falkovich, A.H., Rudich, Y., Maenhaut, W., Artaxo, P. Environ. Sci. Technol. (2005) [Pubmed]

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