Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Bplplp (2S)-2-[[(2R)-4-methyl-2- [[(2S)-2-[[(2R)-4...

Synonyms: SureCN6897460, AC1L2OWE, FT-0641076, A835492, 66556-73-8, ...

Maggi, C.A. et al., Gavins, F.N. et al.

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High impact information on Boc-phe-leu-phe-leu-phe

In FPR-deficient mice, peptide Ac2-26 retained significant inhibitory actions (about 50% of the effects in naive mice), and these were blocked by an FPR antagonist, termed butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe, or Boc2 [1].
This inhibitory effect was unchanged by in vitro capsaicin desensitization or HOE 140 while it was abolished by indomethacin or BPLPLP pretreatment [2].
The response to bradykinin was blocked by HOE 140 and was unaffected by in vitro capsaicin desensitization, indomethacin, MEN 10,376 or BPLPLP [2].

References

Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Gavins, F.N., Yona, S., Kamal, A.M., Flower, R.J., Perretti, M. Blood (2003) [Pubmed]
Local motor responses to bradykinin and bacterial chemotactic peptide formyl-methionyl-leucyl-phenylalanine (FMLP) in the guinea-pig isolated renal pelvis and ureter. Maggi, C.A., Santicioli, P., Del Bianco, E., Giuliani, S. J. Urol. (1992) [Pubmed]

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