Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Anthglutin 2-[2-[(4S)-4-amino-4- carboxy...

Synonyms: GGCPH, SureCN8766412, AR-1D7549, AC1L2P42, AC1Q5QL3, ...

Jones, T.W. et al., Viña, J.R. et al., Selvaraj, P. et al., Komai, T. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Anthglutin

Adult liver enzyme showed a 4 time higher Ki value for anthglutin than hepatoma and fetal liver [1].

High impact information on Anthglutin

Blocking PCBG metabolism by inhibition of gamma-glutamyl transpeptidase [1-gamma-L-glutamyl-2-(2-carboxyphenyl)hydrazine (anthglutin), 2 mM] or renal cysteine conjugate beta-lyase (aminooxyacetic acid, 0.5 mM) resulted in complete protection against PCBG-induced cell damage [2].
A severe decrease in uptake of amino acids at the peak of lactation is provoked by anthglutin, an inhibitor of gamma-glutamyltranspeptidase (GGT) [3].
A specific inhibitor of gamma-glutamyltranspeptidase, anthglutin, inhibited the hydrolysis [4].

References

Isolation of gamma-glutamyl transpeptidase from human primary hepatoma and comparison of its kinetic and catalytic properties with the enzyme from normal adult and fetal liver. Selvaraj, P., Balasubramanian, K.A., Hill, P.G. Enzyme (1981) [Pubmed]
The mechanism of pentachlorobutadienyl-glutathione nephrotoxicity studied with isolated rat renal epithelial cells. Jones, T.W., Wallin, A., Thor, H., Gerdes, R.G., Ormstad, K., Orrenius, S. Arch. Biochem. Biophys. (1986) [Pubmed]
Role of the gamma-glutamyl cycle in the regulation of amino acid translocation. Viña, J.R., Palacin, M., Puertes, I.R., Hernandez, R., Viña, J. Am. J. Physiol. (1989) [Pubmed]
In vitro studies on the metabolic pathway of SQ 14225 (Captopril) and mechanism of mixed disulfide formation. Komai, T., Ikeda, T., Kawai, K., Kameyama, E., Shindo, H. J. Pharmacobio-dyn. (1981) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share