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Gene Review

Ccbl1  -  cysteine conjugate-beta lyase, cytoplasmic

Rattus norvegicus

Synonyms: Cysteine-S-conjugate beta-lyase, GTK, Glutamine transaminase K, Glutamine--phenylpyruvate transaminase, Gtk, ...
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Disease relevance of Ccbl1


High impact information on Ccbl1


Chemical compound and disease context of Ccbl1


Biological context of Ccbl1


Anatomical context of Ccbl1


Associations of Ccbl1 with chemical compounds

  • The role of rat kidney cysteine conjugate beta-lyase in the production of nephrotoxic thiols from S-cysteine conjugates of xenobiotics has been well established [13].
  • On the other hand, the beta-lyase reaction catalyzed by GTK may be useful in the conversion of some cysteine S-conjugate prodrugs to active components in vivo [1].
  • Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain [15].
  • GTK is one of several pyridoxal 5'-phosphate (PLP)-containing enzymes that can catalyze non-physiological beta-elimination reactions with cysteine S-conjugates containing a good leaving group attached at the sulfur [1].
  • However, owing to strong competition from other amino acid substrates, the turnover of kynurenine to kynurenate by GTK/KAT I in nervous tissue must be slow unless kynurenine and GTK are sequestered in a compartment distinct from the major amino acid pools [1].

Regulatory relationships of Ccbl1


Other interactions of Ccbl1


Analytical, diagnostic and therapeutic context of Ccbl1


  1. The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants. Cooper, A.J. Neurochem. Int. (2004) [Pubmed]
  2. Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs. Mosca, M., Croci, C., Mostardini, M., Breton, J., Malyszko, J., Avanzi, N., Toma, S., Benatti, L., Gatti, S. Biochim. Biophys. Acta (2003) [Pubmed]
  3. Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. Lash, L.H., Anders, M.W. J. Biol. Chem. (1986) [Pubmed]
  4. Effects of in vivo sodium azide administration on the immunohistochemical localization of kynurenine aminotransferase in the rat brain. Knyihár-Csillik, E., Okuno, E., Vécsei, L. Neuroscience (1999) [Pubmed]
  5. Metabolism of leukotriene E4 to 5-hydroxy-6-mercapto7,9-trans-11,14-cis-eicosatetraenoic acid by microfloral cysteine-conjugate beta-lyase and rat cecum contents. Bernström, K., Larsen, G.L., Hammarström, S. Arch. Biochem. Biophys. (1989) [Pubmed]
  6. Cloning and functional expression of a soluble form of kynurenine/alpha-aminoadipate aminotransferase from rat kidney. Buchli, R., Alberati-Giani, D., Malherbe, P., Köhler, C., Broger, C., Cesura, A.M. J. Biol. Chem. (1995) [Pubmed]
  7. The mechanism of cysteine conjugate cytotoxicity in renal epithelial cells. Covalent binding leads to thiol depletion and lipid peroxidation. Chen, Q., Jones, T.W., Brown, P.C., Stevens, J.L. J. Biol. Chem. (1990) [Pubmed]
  8. The role of mitochondrial matrix enzymes in the metabolism and toxicity of cysteine conjugates. Stevens, J.L., Ayoubi, N., Robbins, J.D. J. Biol. Chem. (1988) [Pubmed]
  9. Immunochemical evidence against the involvement of cysteine conjugate beta-lyase in compound A nephrotoxicity in rats. Njoku, D.B., Pohl, L.R., Sokoloski, E.A., Marchick, M.R., Borkowf, C.B., Martin, J.L. Anesthesiology (1999) [Pubmed]
  10. Nephrotoxicity of 2-bromo-(cystein-S-yl) hydroquinone and 2-bromo-(N-acetyl-L-cystein-S-yl) hydroquinone thioethers. Monks, T.J., Jones, T.W., Hill, B.A., Lau, S.S. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  11. Nephrotoxicity of sevoflurane compound A [fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether] in rats: evidence for glutathione and cysteine conjugate formation and the role of renal cysteine conjugate beta-lyase. Jin, L., Baillie, T.A., Davis, M.R., Kharasch, E.D. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  12. Elevated concentrations of kynurenic acid, a tryptophan derivative, in dense nuclear cataracts. Zarnowski, T., Rejdak, R., Zielinska-Rzecka, E., Zrenner, E., Grieb, P., Zagórski, Z., Junemann, A., Turski, W.A. Curr. Eye Res. (2007) [Pubmed]
  13. Isolation and expression of a cDNA coding for rat kidney cytosolic cysteine conjugate beta-lyase. Perry, S.J., Schofield, M.A., MacFarlane, M., Lock, E.A., King, L.J., Gibson, G.G., Goldfarb, P.S. Mol. Pharmacol. (1993) [Pubmed]
  14. Molecular cloning and expression of a cDNA for human kidney cysteine conjugate beta-lyase. Perry, S., Harries, H., Scholfield, C., Lock, T., King, L., Gibson, G., Goldfarb, P. FEBS Lett. (1995) [Pubmed]
  15. Identification of a mitochondrial form of kynurenine aminotransferase/glutamine transaminase K from rat brain. Malherbe, P., Alberati-Giani, D., Köhler, C., Cesura, A.M. FEBS Lett. (1995) [Pubmed]
  16. Cloning and expression of a rat kidney cytosolic glutamine transaminase K that has strong sequence homology to kynurenine pyruvate aminotransferase. Abraham, D.G., Cooper, A.J. Arch. Biochem. Biophys. (1996) [Pubmed]
  17. Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K. Mosca, M., Cozzi, L., Breton, J., Speciale, C., Okuno, E., Schwarcz, R., Benatti, L. FEBS Lett. (1994) [Pubmed]
  18. Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. Lash, L.H., Elfarra, A.A., Anders, M.W. J. Biol. Chem. (1986) [Pubmed]
  19. The effect of haloalkene cysteine conjugates on rat renal glutathione reductase and lipoyl dehydrogenase activities. Lock, E.A., Schnellmann, R.G. Toxicol. Appl. Pharmacol. (1990) [Pubmed]
  20. Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity. Stevens, J.L. J. Biol. Chem. (1985) [Pubmed]
  21. Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene. Dohn, D.R., Leininger, J.R., Lash, L.H., Quebbemann, A.J., Anders, M.W. J. Pharmacol. Exp. Ther. (1985) [Pubmed]
  22. Aminotransferase, L-amino acid oxidase and beta-lyase reactions involving L-cysteine S-conjugates found in allium extracts. Relevance to biological activity? Cooper, A.J., Pinto, J.T. Biochem. Pharmacol. (2005) [Pubmed]
  23. Kynurenine aminotransferase I (KATI) isoform gene expression in the rat brain: an in situ hybridization study. Tamburin, M., Mostardini, M., Benatti, L. Neuroreport (1999) [Pubmed]
  24. Glutamine transaminase K and cysteine S-conjugate beta-lyase activity stains. Abraham, D.G., Cooper, A.J. Anal. Biochem. (1991) [Pubmed]
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