Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Acaterin (5R)-3-[(1R)-1-hydroxyoctyl]- 5-methyl-5H...

Synonyms: SureCN1231200, AC1L2QZI, 144398-20-9, 3-(1-Hydroxyoctyl)-5-methyl-2(5H)-furanone, 2(5H)-Furanone, 3-(1-hydroxyoctyl)-5-methyl-

Naganuma, S. et al., Nakano, S. et al.

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Disease relevance of Acaterin

The mechanism of the reduction was investigated with a cell-free preparation obtained from the acaterin-producing microorganism, Pseudomonas sp. A 92 [1].

High impact information on Acaterin

Kinetic studies suggested that inhibition of ACAT by acaterin was noncompetitive with respect to oleoyl-CoA [2].

Anatomical context of Acaterin

Acaterin also inhibited ACAT activity in the rat liver microsomes by 50% at a concentration of 120 microM [2].

Analytical, diagnostic and therapeutic context of Acaterin

Acaterin, a novel inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), was isolated from a culture broth of Pseudomonas sp. A92 by Diaion HP-20 column chromatography, solvent extraction and reverse phase HPLC [2].

References

Biosynthesis of acaterin: mechanism of the reaction catalyzed by dehydroacaterin reductase. Nakano, S., Sakane, W., Oinaka, H., Fujimoto, Y. Bioorg. Med. Chem. (2006) [Pubmed]
Acaterin, a novel inhibitor of acyl-CoA: cholesterol acyltransferase produced by Pseudomonas sp. A92. Naganuma, S., Sakai, K., Hasumi, K., Endo, A. J. Antibiot. (1992) [Pubmed]

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