Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CCRIS 6865 2-chloroprop-1-en-1-one

Synonyms: LS-14612, CTK9A0734, BRN 1735675, AC1L2057, 2-Chloroacrolein, ...

Segall, Y. et al., Schneider, M. et al.

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Disease relevance of CCRIS 6865

Mutagenicity assays in Salmonella typhimurium TA100 (standard plate incorporation) establish high potencies of 37, 17, and 150 revertants/nmol for cis- and trans-1, 3-D-epoxides and 2-chloroacrolein, respectively [1].

High impact information on CCRIS 6865

The mutagenic potency on metabolic activation of the herbicide diallate by microsomes or the S9 fraction is attributable to approximately 50% conversion to 2-chloropropenal when corrected for detoxification in these systems or with GSH [2].

References

1,3-Dichloropropene epoxides: intermediates in bioactivation of the promutagen 1,3-dichloropropene. Schneider, M., Quistad, G.B., Casida, J.E. Chem. Res. Toxicol. (1998) [Pubmed]
3-Substituted 2-halopropenals: mutagenicity, detoxification and formation from 3-substituted 2,3-dihalopropanal promutagens. Segall, Y., Kimmel, E.C., Dohn, D.R., Casida, J.E. Mutat. Res. (1985) [Pubmed]

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