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Chemical Compound Review: 

AHBA     3-amino-5-hydroxy-benzoic acid

Synonyms: PubChem17213, SureCN571808, AG-H-03333, CHEBI:29507, ANW-61669, ...
 
 
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Disease relevance of C12107

  • The polyketide chains of the two ansamycin antibiotics, ansatrienin (mycotrienin) and naphthomycin produced by Streptomyces collinus are assembled using 3-amino-5-hydroxybenzoic acid (AHBA) as a starter unit [1].
  • A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit [2].
 

High impact information on C12107

References

  1. Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. Chen, S., von Bamberg, D., Hale, V., Breuer, M., Hardt, B., Müller, R., Floss, H.G., Reynolds, K.A., Leistner, E. Eur. J. Biochem. (1999) [Pubmed]
  2. A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit. Ghisalba, O., Nüesch, J. J. Antibiot. (1981) [Pubmed]
  3. Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061. Sohng, J.K., Oh, T.J., Lee, J.J., Kim, C.G. Mol. Cells (1997) [Pubmed]
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