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Disease relevance of Nocardia


High impact information on Nocardia

  • Minocycline hydrochloride was used to treat pulmonary infections with Nocardia asteroides in five cardiac allograft recipients [6].
  • These LP-activated blasts can be restimulated by the homologous LP and by Nocardia mitogen and mitogens of fetal calf serum, but not by LPS [7].
  • Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans [8].
  • The protein sequence of the Nocardia sp NAD(P)-dependent cholesterol dehydrogenase responsible for the conversion of cholesterol to its 3-keto derivative shows 30% similarity to a 329-aa Saccharomyces ORF, YGL001c, suggesting a possible role of YGL001c in sterol decarboxylation [9].
  • The type species, Nocardia asteroides, and N. brasiliensis, N. farcinica, N. otitidiscaviarum, N. nova, and N. transvalensis cause a variety of diseases in both normal and immunocompromised humans and animals [10].

Chemical compound and disease context of Nocardia

  • Immune stimulation by methanol-extracted residue of Bacillus Calmette-Guérin or cell wall skeleton of Nocardia rubra did not affect mammary carcinoma incidence when administered either alone or in combination with RA and/or HI [11].
  • The response to anti-allotype (anti-Ab4), Nocardia Water Soluble Mitogen (NWSM), pneumococcal polysaccharide type III (SSS III), and human Fc fragments of various purified and unfractionated rabbit spleen cell populations was determined in terms of 3H-thymidine up-take [12].
  • A new enzyme capable of hydrolyzing chitobiose, which is an induced enzyme, was purified to apparent homogeneity from the culture filtrate of Nocardia orientalis IFO 12806 [13].
  • Virus release can also be efficiently stimulated by other naturally occurring B cell mitogens, including Nocardia water soluble mitogen, and PPD [14].
  • Recombinant hIntL revealed affinities to d-pentoses and a d-galactofuranosyl residue in the presence of Ca(2+), and recognized the bacterial arabinogalactan of Nocardia containing d-galactofuranosyl residues [15].

Biological context of Nocardia


Anatomical context of Nocardia


Gene context of Nocardia


Analytical, diagnostic and therapeutic context of Nocardia


  1. Actinomycetales infection in the acquired immunodeficiency syndrome. Holtz, H.A., Lavery, D.P., Kapila, R. Ann. Intern. Med. (1985) [Pubmed]
  2. Induction of tumoricidal activity of polymorphonuclear leukocytes by a linear beta-1,3-D-glucan and other immunomodulators in murine cells. Morikawa, K., Takeda, R., Yamazaki, M., Mizuno, D. Cancer Res. (1985) [Pubmed]
  3. Inhibition of pulmonary metastasis by Nocardia rubra cell wall skeleton, with special reference to macrophage activation. Kagawa, K., Yamashita, T., Tsubura, E., Yamamura, Y. Cancer Res. (1984) [Pubmed]
  4. Isolation of vitamin K2(35) from Nocardia restrictus and Corynebacterium simplex. A natural electron acceptor in microbial steroid ring A dehydrogenations. Abul-Hajj, Y.J. J. Biol. Chem. (1978) [Pubmed]
  5. Pneumocystis carinii infection in heart transplant recipients. Efficacy of a weekend prophylaxis schedule. Muñoz, P., Muñoz, R.M., Palomo, J., Rodríguez-Creixéms, M., Muñoz, R., Bouza, E. Medicine (Baltimore) (1997) [Pubmed]
  6. Minocycline treatment of pulmonary nocardiosis. Petersen, E.A., Nash, M.L., Mammana, R.B., Copeland, J.G. JAMA (1983) [Pubmed]
  7. Mitogen-activated B-cell blasts reactive to more than one mitogen. Andersson, J., Coutinho, A., Melchers, F. J. Exp. Med. (1979) [Pubmed]
  8. Genes for a beta-lactamase, a penicillin-binding protein and a transmembrane protein are clustered with the cephamycin biosynthetic genes in Nocardia lactamdurans. Coque, J.J., Liras, P., Martín, J.F. EMBO J. (1993) [Pubmed]
  9. Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Gachotte, D., Barbuch, R., Gaylor, J., Nickel, E., Bard, M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  10. Nocardia species: host-parasite relationships. Beaman, B.L., Beaman, L. Clin. Microbiol. Rev. (1994) [Pubmed]
  11. Retinoid feeding, hormone inhibition, and/or immune stimulation and the genesis of carcinogen-induced rat mammary carcinomas. Welsch, C.W., DeHoog, J.V. Cancer Res. (1983) [Pubmed]
  12. Rabbit B spleen lymphocytes and T helper cells. I. Responsiveness to mitogens of B cell subpopulations of different sedimentation velocities and subpopulations bearing or lacking Fcgamma receptors. Cavaillon, J.M., Udupa, T.N., Chou, C.T., Cinader, B., Haeffner-Cavaillon, N., Dubiski, S. J. Immunol. (1979) [Pubmed]
  13. Purification and characterization of an exo-beta-D-glucosaminidase, a novel type of enzyme, from Nocardia orientalis. Nanjo, F., Katsumi, R., Sakai, K. J. Biol. Chem. (1990) [Pubmed]
  14. Genetic factors infuencing mouse type-C RNA virus induction by naturally occurring B cell mitogens. Phillips, S.M., Stephenson, J.R., Aaronson, S.A. J. Immunol. (1977) [Pubmed]
  15. Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall. Tsuji, S., Uehori, J., Matsumoto, M., Suzuki, Y., Matsuhisa, A., Toyoshima, K., Seya, T. J. Biol. Chem. (2001) [Pubmed]
  16. Contribution of rpoB2 RNA Polymerase {beta} Subunit Gene to Rifampin Resistance in Nocardia Species. Ishikawa, J., Chiba, K., Kurita, H., Satoh, H. Antimicrob. Agents Chemother. (2006) [Pubmed]
  17. Beta-lactam resistance in Nocardia brasiliensis is mediated by beta-lactamase and reversed in the presence of clavulanic acid. Wallace, R.J., Nash, D.R., Johnson, W.K., Steele, L.C., Steingrube, V.A. J. Infect. Dis. (1987) [Pubmed]
  18. Biochemical-genetic analysis and distribution of FAR-1, a class A beta-lactamase from Nocardia farcinica. Laurent, F., Poirel, L., Naas, T., Chaibi, E.B., Labia, R., Boiron, P., Nordmann, P. Antimicrob. Agents Chemother. (1999) [Pubmed]
  19. Biotransformation of quinovic acid glycosides by microbes: direct conversion of the ursane to the oleanane triterpene skeleton by Nocardia sp. NRRL 5646. Cheng, Z.H., Yu, B.Y., Cordell, G.A., Qiu, S.X. Org. Lett. (2004) [Pubmed]
  20. Murine polymorphonuclear neutrophils produce interferon-gamma in response to pulmonary infection with Nocardia asteroides. Ellis, T.N., Beaman, B.L. J. Leukoc. Biol. (2002) [Pubmed]
  21. Suppression of polyclonal immunoglobulin biosynthesis by a soluble factor: T-cell dependent and T-cell independent mitogens. Krakauer, R.S., Cathcart, M.K., Ilfeld, D.N. Immunology (1980) [Pubmed]
  22. Analysis of therapeutic effect in experimental chemoimmunotherapy for rat ascites tumor. Ogura, T., Shinzato, O., Sakatani, M., Shindo, H., Namba, M., Kishimoto, S., Yamamura, Y. Cancer Immunol. Immunother. (1982) [Pubmed]
  23. Effects of Nocardia rubra cell wall skeleton on interleukin 2 production and lymphocyte proliferation in former poison gas factory workers. Yamakido, M., Yanagida, J., Ishioka, S., Matsuzaka, S., Hozawa, S., Takaishi, M., Akiyama, M., Nishimoto, Y. Jpn. J. Cancer Res. (1986) [Pubmed]
  24. Characterization of dopamine-depleting activity of Nocardia asteroides strain GUH-2 culture filtrate on PC12 cells. Loeffler, D.A., Camp, D.M., Qu, S., Beaman, B.L., LeWitt, P.A. Microb. Pathog. (2004) [Pubmed]
  25. Augmentation of murine lymphokine-activated killer cell induction by a factor produced by Nocardia rubra cell wall skeleton-stimulated T cells. Kawase, I., Shirasaka, T., Ikeda, T., Hara, H., Tanio, Y., Watanabe, M., Saito, S., Masuno, T., Kishimoto, S., Yamamura, Y. Jpn. J. Cancer Res. (1989) [Pubmed]
  26. Bacterial clearance and survival are dependent on CXC chemokine receptor-2 ligands in a murine model of pulmonary Nocardia asteroides infection. Moore, T.A., Newstead, M.W., Strieter, R.M., Mehrad, B., Beaman, B.L., Standiford, T.J. J. Immunol. (2000) [Pubmed]
  27. The chromosomal integration site of the Streptomyces element pSAM2 overlaps a putative tRNA gene conserved among actinomycetes. Mazodier, P., Thompson, C., Boccard, F. Mol. Gen. Genet. (1990) [Pubmed]
  28. Activation in vitro of peritoneal macrophages by a nocardia fraction. Ben-Efraim, S., Rashid, G., Gittel, H., Tax, C., Ciorbaru, R.B. Anticancer Res. (1994) [Pubmed]
  29. Susceptibility of Nocardia asteroides to new quinolones and beta-lactams. Gombert, M.E., Aulicino, T.M., duBouchet, L., Berkowitz, L.R. Antimicrob. Agents Chemother. (1987) [Pubmed]
  30. Isolation of mitogenic and adjuvant active fractions from various species of Nocardiae. Ciorbaru, R., Adam, A., Petit, J.F., Lederer, E., Bona, C., Chedid, L. Infect. Immun. (1975) [Pubmed]
  31. Purification, characterization, and properties of an aryl aldehyde oxidoreductase from Nocardia sp. strain NRRL 5646. Li, T., Rosazza, J.P. J. Bacteriol. (1997) [Pubmed]
  32. Immunostimulation in the urinary bladder by local application of Nocardia rubra cell-wall skeletons (Rubratin) and bacillus Calmette-Guérin as therapy for superficial bladder cancer: a comparative study. de Boer, E.C., De Reijke, T.M., Vos, P.C., Kurth, K.H., Schamhart, D.H. Clin. Infect. Dis. (2000) [Pubmed]
  33. Crystallization of NAD+-dependent phenylalanine dehydrogenase from Nocardia sp239. Pasquo, A., Britton, K.L., Baker, P.J., Brearley, G., Hinton, R.J., Moir, A.J., Stillman, T.J., Rice, D.W. Acta Crystallogr. D Biol. Crystallogr. (1998) [Pubmed]
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