Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AG-G-56582 2-(2-fluorophenyl)-4-hydroxy- 6-methyl-10...

Synonyms: SureCN10968440, LS-34294, CTK2F3821, AR-1G5036, DP 327, ...

Gafni, I. et al., Bogusz, M.J. et al., Kilicarslan, T. et al., Coller, J.K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on DP 327

The authors conclude that CYP2C19 contributes to the metabolism of flunitrazepam to desmethylflunitrazepam and 3-hydroxyflunitrazepam in vivo, but these data suggest that its role is minor and that differences in CYP2C19 activity do not likely substantially influence its clinical effects [1].
Human CYP2C19 and CYP3A4 mediated the formation of desmethylflunitrazepam with Km values of 11.1 and 108 microM, respectively, and 3-hydroxyflunitrazepam with Km values of 642 and 34.0 microM, respectively [2].
A selective assay of flunitrazepam (F) and its metabolites 7-aminoflunitrazepam (7-AF), N-desmethylflunitrazepam (N-DF) and 3-hydroxyflunitrazepam (3-OHF) with liquid chromatography-atmospheric pressure chemical ionization mass spectrometry (LC-APCI-MS, positive ions) is described [3].

Analytical, diagnostic and therapeutic context of DP 327

Quantification of flunitrazepam's oxidative metabolites, 3-hydroxyflunitrazepam and desmethylflunitrazepam, in hepatic microsomal incubations by high-performance liquid chromatography [4].

References

The role of cytochrome P450 2C19 activity in flunitrazepam metabolism in vivo. Gafni, I., Busto, U.E., Tyndale, R.F., Kaplan, H.L., Sellers, E.M. Journal of clinical psychopharmacology. (2003) [Pubmed]
Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4. Kilicarslan, T., Haining, R.L., Rettie, A.E., Busto, U., Tyndale, R.F., Sellers, E.M. Drug Metab. Dispos. (2001) [Pubmed]
Determination of flunitrazepam and its metabolites in blood by high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Bogusz, M.J., Maier, R.D., Krüger, K.D., Früchtnicht, W. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
Quantification of flunitrazepam's oxidative metabolites, 3-hydroxyflunitrazepam and desmethylflunitrazepam, in hepatic microsomal incubations by high-performance liquid chromatography. Coller, J.K., Somogyi, A.A., Bochner, F. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

Editor

Share