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Chemical Compound Review

Fluninoc     2-(2-fluorophenyl)-6-methyl- 10-nitro-3,6...

Synonyms: Narcozep, Rohipnol, Rohypnol, Flunibeta, Flunimerck, ...
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Disease relevance of Narcozep


Psychiatry related information on Narcozep


High impact information on Narcozep


Chemical compound and disease context of Narcozep


Biological context of Narcozep


Anatomical context of Narcozep

  • In a previous report we described the use of flunitrazepam as a photoaffinity label to monitor the turnover of the gamma-aminobutyric acid/benzodiazepine receptor complex in primary brain and spinal cord cell cultures [Science (Wash. D. C.) 226:857-860 (1984)] [22].
  • Fluorography of a sodium dodecyl sulfate-polyacrylamide electrophoresis gel of solubilized hepatic microsomes that had been treated with [3H] flunitrazepam under UV light revealed a band with a monomeric molecular weight between 54,000 and 58,000 [23].
  • This postulate was based upon evidence showing changes in binding properties of the BZD receptor following photoaffinity labeling of membranes with flunitrazepam (FLU) [24].
  • Photoaffinity labeling of the flunitrazepam receptor in PSDs resulted in the binding to a 51,000 Mr protein in both cases, with cerebellar PSDs again showing an increased concentration over that found in cerebral cortex PSDs [25].
  • In the present paper it is shown that suriclone possesses a high affinity for flunitrazepam binding sites and that tritiated suriclone binds specifically with high affinity in rat hippocampus (KD = 0.44 +/- 0.03 nM) and rat cerebellum (KD = 0.53 +/- 0.12 nM) [26].

Associations of Narcozep with other chemical compounds


Gene context of Narcozep


Analytical, diagnostic and therapeutic context of Narcozep


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  32. Granule cell disinhibition in dentate gyrus of genetically seizure susceptible El mice. Ono, T., Fueta, Y., Janjua, N.A., Ohmori, O., Ohno, K., Murai, Y., Mita, T. Brain Res. (1997) [Pubmed]
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  34. Ethanol, flunitrazepam, and pentobarbital modulation of GABAA receptors expressed in mammalian cells and Xenopus oocytes. Harris, R.A., Mihic, S.J., Brozowski, S., Hadingham, K., Whiting, P.J. Alcohol. Clin. Exp. Res. (1997) [Pubmed]
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