Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

CHEMBL151121 10-amino-2-(2-fluorophenyl)- 6-methyl-3,6...

Synonyms: SureCN11072824, AC1L3NTM, AC1Q4OLF, CTK8D9548, AR-1H3141, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Ro 20-1815

Determination of 7-amino-flunitrazepam (Ro 20-1815) and 7-amino-desmethylflunitrazepam (Ro 5-4650) in plasma by high-performance liquid chromatography and fluorescence detection [1].
The forensic toxicology community has recognized flunitrazepam and its metabolite (7-aminoflunitrazepam) as compounds of concern for several years [2].
These samples were analyzed by an ELISA that was developed using an antibody raised to flunitrazepam and a drug-enzyme conjugate prepared by attaching 7-aminoflunitrazepam to horseradish peroxidase [3].

Associations of Ro 20-1815 with other chemical compounds

A procedure based on gas chromatography-mass spectrometry (GC-MS) is described for the simultaneous analysis of buprenorphine, norbuprenorphine (NBUP), flunitrazepam, N-desmethylflunitrazepam (N-DMFNZ) and 7-aminoflunitrazepam (7-AFNZ) in rat plasma [4].

Analytical, diagnostic and therapeutic context of Ro 20-1815

For one example, 7-aminoflunitrazepam, the MECC data are shown to agree well with those obtained by gas chromatography/mass spectrometry [5].
Performance characteristics of 7-aminoflunitrazepam specific enzyme-linked immunosorbent assays [6].
Immunoassays for benzodiazepines do not discriminate between different benzodiazepines, and certain metabolites, such as 7-aminoflunitrazepam, react poorly with immunoassay reagents [7].
Highly sensitive micro-plate enzyme immunoassay screening and NCI-GC-MS confirmation of flunitrazepam and its major metabolite 7-aminoflunitrazepam in hair [8].

References

Determination of 7-amino-flunitrazepam (Ro 20-1815) and 7-amino-desmethylflunitrazepam (Ro 5-4650) in plasma by high-performance liquid chromatography and fluorescence detection. Sumirtapura, Y.C., Aubert, C., Coassolo, P., Cano, J.P. J. Chromatogr. (1982) [Pubmed]
Extraction and analysis of flunitrazepam/7-aminoflunitrazepam in blood and urine by LC-PDA and GC-MS using butyl SPE columns. Hackett, J., Elian, A.A. Forensic Sci. Int. (2006) [Pubmed]
A sensitive immunoassay for flunitrazepam and metabolites. Walshe, K., Barrett, A.M., Kavanagh, P.V., McNamara, S.M., Moran, C., Shattock, A.G. Journal of analytical toxicology. (2000) [Pubmed]
Development and validation of a gas chromatography-mass spectrometry method for the simultaneous determination of buprenorphine, flunitrazepam and their metabolites in rat plasma: application to the pharmacokinetic study. Pirnay, S., Bouchonnet, S., Hervé, F., Libong, D., Milan, N., D'Athis, P., Baud, F., Ricordel, I. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2004) [Pubmed]
Micellar electrokinetic capillary chromatography of benzodiazepines in human urine. Schafroth, M., Thormann, W., Allemann, D. Electrophoresis (1994) [Pubmed]
Performance characteristics of 7-aminoflunitrazepam specific enzyme-linked immunosorbent assays. Lin, D.L., Yin, R.M., Chen, C.H., Chen, Y.L., Liu, R.H. Journal of analytical toxicology. (2005) [Pubmed]
Benzodiazepines in Miami-Dade County, Florida driving under the influence (DUI) cases (1995-1998) with emphasis on Rohypnol: GC-MS confirmation, patterns of use, psychomotor impairment, and results of Florida legislation. Raymon, L.P., Steele, B.W., Walls, H.C. Journal of analytical toxicology. (1999) [Pubmed]
Highly sensitive micro-plate enzyme immunoassay screening and NCI-GC-MS confirmation of flunitrazepam and its major metabolite 7-aminoflunitrazepam in hair. Negrusz, A., Moore, C., Deitermann, D., Lewis, D., Kaleciak, K., Kronstrand, R., Feeley, B., Niedbala, R.S. Journal of analytical toxicology. (1999) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.