Chemical Compound Review:
ACMC-1C12P 8-chloro-4-(2-chloro-4- fluoro...
Synonyms:
AG-D-52252, SureCN7044612, AC1L2WYE, CTK4B3930, DCL000358, ...
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Disease relevance of LY214352
- The LY214352-resistance gene coded for a protein of 520 amino acids that had a 34% identity and a 57% similarity in a 333 amino-acid overlap to E. coli dihydroorotate dehydrogenase (DHO-DH) [1].
High impact information on LY214352
- Several mutations in the DHO-DH (pyrE) gene that resulted in resistance to LY214352 were identified [1].
- The results of a series of biochemical mechanism-of-action studies initiated simultaneously with molecular-genetic experiments also suggested that DHO-DH was the target of LY214352 [1].
- In the molecular-genetics approach, a cosmid library was prepared from an Aspergillus nidulans mutant that was resistant to LY214352 because of a dominant mutation in a single gene [1].
Biological context of LY214352
- The target site of the antifungal compound LY214352 [8-chloro-4-(2-chloro-4-fluorophenoxy) quinoline] has been identified through a dual biochemical and molecular-genetics approach [1].
- A single cosmid (6A6-6) that could transform an LY214352-sensitive strain of A. nidulans to LY214352-resistance was isolated from the library by sib-selection [1].
References
- Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach. Gustafson, G., Davis, G., Waldron, C., Smith, A., Henry, M. Curr. Genet. (1996) [Pubmed]
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