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Chemical Compound Review

ACMC-1C12P     8-chloro-4-(2-chloro-4- fluoro...

Synonyms: AG-D-52252, SureCN7044612, AC1L2WYE, CTK4B3930, DCL000358, ...
 
 
 
 
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Disease relevance of LY214352

 

High impact information on LY214352

 

Biological context of LY214352

  • The target site of the antifungal compound LY214352 [8-chloro-4-(2-chloro-4-fluorophenoxy) quinoline] has been identified through a dual biochemical and molecular-genetics approach [1].
  • A single cosmid (6A6-6) that could transform an LY214352-sensitive strain of A. nidulans to LY214352-resistance was isolated from the library by sib-selection [1].

References

  1. Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach. Gustafson, G., Davis, G., Waldron, C., Smith, A., Henry, M. Curr. Genet. (1996) [Pubmed]
 
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