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Gene Review

pyrD  -  dihydro-orotate oxidase, FMN-linked

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0936, JW0928
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Disease relevance of pyrD


High impact information on pyrD


Chemical compound and disease context of pyrD


Biological context of pyrD


Associations of pyrD with chemical compounds

  • In this study we investigated C. albicans dihydroorotate dehydrogenase (DHODH, EC, which catalyzes the fourth step of de novo pyrimidine synthesis, as a new target for controlling infection [8].


  1. Nucleotide sequence of the pyrD gene of Escherichia coli and characterization of the flavoprotein dihydroorotate dehydrogenase. Larsen, J.N., Jensen, K.F. Eur. J. Biochem. (1985) [Pubmed]
  2. Nucleotide pool-sensitive selection of the transcriptional start site in vivo at the Salmonella typhimurium pyrC and pyrD promoters. Sørensen, K.I., Baker, K.E., Kelln, R.A., Neuhard, J. J. Bacteriol. (1993) [Pubmed]
  3. Genetic diversity and kinetic properties of Trypanosoma cruzi dihydroorotate dehydrogenase isoforms. Sariego, I., Annoura, T., Nara, T., Hashimoto, M., Tsubouchi, A., Iizumi, K., Makiuchi, T., Murata, E., Kita, K., Aoki, T. Parasitol. Int. (2006) [Pubmed]
  4. Sequence analysis and identification of the pyrKDbF operon from Lactococcus lactis including a novel gene, pyrK, involved in pyrimidine biosynthesis. Andersen, P.S., Martinussen, J., Hammer, K. J. Bacteriol. (1996) [Pubmed]
  5. Cloning, expression, purification, and characterization of Leishmania major dihydroorotate dehydrogenase. Feliciano, P.R., Cordeiro, A.T., Costa-Filho, A.J., Nonato, M.C. Protein Expr. Purif. (2006) [Pubmed]
  6. Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach. Gustafson, G., Davis, G., Waldron, C., Smith, A., Henry, M. Curr. Genet. (1996) [Pubmed]
  7. E. coli dihydroorotate dehydrogenase reveals structural and functional distinctions between different classes of dihydroorotate dehydrogenases. Nørager, S., Jensen, K.F., Björnberg, O., Larsen, S. Structure (Camb.) (2002) [Pubmed]
  8. Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans. Zameitat, E., Gojković, Z., Knecht, W., Piskur, J., Löffler, M. FEBS J. (2006) [Pubmed]
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