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Chemical Compound Review:

EB-1053 disodium (1-hydroxy-1-phosphonato-3...

Synonyms: EB 1053, AC1L2Y2V, 125946-92-1

This record was replaced with 130822.

van der Pluijm, G. et al.

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Disease relevance of (1-hydroxy-1-phosphono-3-pyrrolidin-1-yl-propyl)phosphonic acid

Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo [1].

High impact information on (1-hydroxy-1-phosphono-3-pyrrolidin-1-yl-propyl)phosphonic acid

The EB-1053-inhibited osteoclastic resorption could be reversed by treatment with parathyroid hormone (PTH) [1].

Analytical, diagnostic and therapeutic context of (1-hydroxy-1-phosphono-3-pyrrolidin-1-yl-propyl)phosphonic acid

In vivo, daily subcutaneous injections of EB-1053 to young growing rats for 7 days increased metaphyseal bone mass in tibiae dose dependently [1].

References

Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo. van der Pluijm, G., Binderup, L., Bramm, E., van der Wee-Pals, L., De Groot, H., Binderup, E., Löwik, C., Papapoulos, S. J. Bone Miner. Res. (1992) [Pubmed]

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