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Chemical Compound Review

sodiosodium     sodiosodium

Synonyms: AC1L3IMW, 25681-79-2, disodium(Na-Na)
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Disease relevance of SODIUM


Psychiatry related information on SODIUM

  • No studies evaluating topical phlebotonics, chromocarbe, naftazone or disodium flavodate fulfilled the inclusion criteria.Outcomes included oedema, venous ulcers, trophic disorders, subjective symptoms (pain, cramps, restless legs, itching, heaviness, swelling and paraesthesias), global assessment measures and side effects [6].

High impact information on SODIUM


Chemical compound and disease context of SODIUM


Biological context of SODIUM


Anatomical context of SODIUM

  • Aurothiomalate disodium antigenicity was demonstrated by increased lymphocyte blastogenesis, and accentuation of blood and splenic leukocyte migration in the presence of the gold salt [22].
  • Xylanpoly-(hydrogen sulphate) disodium salt with a molecular weight of about 6000 daltons (HOE/BAY 946) completely inhibited syncytium formation induced by the infection of T lymphocytes with HIV as well as viral replication at concentrations above 25 micrograms/ml [23].
  • Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra [24].
  • Tiron, a disodium benzene disulphonic acid, broke the DPI-PQQ adduct isolated from neutrophils and released free PQQ [25].
  • Exposure of cultured human fibroblasts to singlet oxygen, generated in a dark reaction by thermodissociation of the endoperoxide of the disodium salt of 3,3'-(1,4-naphthylidene) dipropionate (NDPO2) induced collagenase mRNA steady state levels in a dose dependent manner [26].

Associations of SODIUM with other chemical compounds

  • Studies in which disodium bilirubinate is dissolved in bile salt solutions and pH is adjusted to the physiological range reveal that metastable supersaturation with bilirubin may occur and that a mesophase may also form in the presence of lecithin, akin to that seen with cholesterol.(ABSTRACT TRUNCATED AT 250 WORDS)[27]
  • The response of ionized calcium and parathormone to a standardized disodium EDTA infusion of 50 mg/kg also did not change [28].
  • Clodronate disodium (Cl2/MDP) is primarily excreted unchanged by the kidney; more than 80% of the intravenous dose was recovered within 48 hr [29].
  • Seventeen ribosomal proteins of Saccharomyces cerevisiae were isolated from small ribosomal subunits and disodium ethylenediaminetetraacetate treated 80S ribosomes by chromatography on a column of carboxymethylcellulose and/or by filtration through Sephacryl S-200 [30].
  • In order to evaluate and quantitate the therapeutic efficacy of disodium etridonate (EHDP) in the treatment of Paget's disease, a prospective double-blind study was instituted [31].

Gene context of SODIUM


Analytical, diagnostic and therapeutic context of SODIUM


  1. Differential action of the bisphosphonates (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) and disodium dichloromethylidene bisphosphonate (Cl2MDP) on rat macrophage-mediated bone resorption in vitro. Reitsma, P.H., Teitelbaum, S.L., Bijvoet, O.L., Kahn, A.J. J. Clin. Invest. (1982) [Pubmed]
  2. Disodium azodisalicylate in ulcerative colitis. Jewell, D.P., Truelove, S.C. Lancet (1981) [Pubmed]
  3. Disposition of disodium azodisalicylate in healthy subjects. A possible new drug for inflammatory bowel disease. van Hogezand, R.A., van Hees, P.A., Zwanenburg, B., van Rossum, J.M., van Tongeren, J.H. Gastroenterology (1985) [Pubmed]
  4. Experimental parturient hypocalcemia in cows following prepartal chemical inhibition of bone resportion. Yarrington, J.T., Capen, C.C., Black, H.E., Re, R., Potts, J.T., Geho, W.B. Am. J. Pathol. (1976) [Pubmed]
  5. Clodronate. A randomized study in the treatment of cancer-related hypercalcemia. Witte, R.S., Koeller, J., Davis, T.E., Benson, A.B., Durie, B.G., Lipton, A., Stock, J.L., Citrin, D.L., Jacobs, T.P. Arch. Intern. Med. (1987) [Pubmed]
  6. Phlebotonics for venous insufficiency. Martinez, M.J., Bonfill, X., Moreno, R.M., Vargas, E., Capellà, D. Cochrane database of systematic reviews (Online) (2005) [Pubmed]
  7. Reevaluation of serum-plasma differences in total cholesterol concentration. Cloey, T., Bachorik, P.S., Becker, D., Finney, C., Lowry, D., Sigmund, W. JAMA (1990) [Pubmed]
  8. Oxalate transport by anion exchange across rabbit ileal brush border. Knickelbein, R.G., Aronson, P.S., Dobbins, J.W. J. Clin. Invest. (1986) [Pubmed]
  9. Isolation of a basophilic membrane protein binding the anti-allergic drug cromolyn. Mazurek, N., Bashkin, P., Pecht, I. EMBO J. (1982) [Pubmed]
  10. NADH oxidase activation is involved in arsenite-induced oxidative DNA damage in human vascular smooth muscle cells. Lynn, S., Gurr, J.R., Lai, H.T., Jan, K.Y. Circ. Res. (2000) [Pubmed]
  11. A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. Sugiyama, T., Okuma, M., Ushikubi, F., Sensaki, S., Kanaji, K., Uchino, H. Blood (1987) [Pubmed]
  12. Effect of dichloromethylene diphosphonate in Paget's disease of bone and in hypercalcaemia due to primary hyperparathyroidism or malignant disease. Douglas, D.L., Duckworth, T., Russell, R.G., Kanis, J.A., Preston, C.J., Preston, F.E., Prenton, M.A., Woodhead, J.S. Lancet (1980) [Pubmed]
  13. Direct suppressive effect of acute metabolic and respiratory alkalosis on parathyroid hormone secretion in the dog. Lopez, I., Rodriguez, M., Felsenfeld, A.J., Estepa, J.C., Aguilera-Tejero, E. J. Bone Miner. Res. (2003) [Pubmed]
  14. Use of ticarcillin disodium plus clavulanate potassium in the management of acute bacterial infections in children. Gooch, W.M., Swenson, E., Higbee, M.D. Am. J. Med. (1985) [Pubmed]
  15. Distribution and metabolism in healthy volunteers of disodium azodisalicylate, a potential therapeutic agent for ulcerative colitis. Willoughby, C.P., Aronson, J.K., Agback, H., Bodin, N.O., Truelove, S.C. Gut (1982) [Pubmed]
  16. Effects of sulphasalazine and disodium azodisalicylate on colonic PGE2 concentrations determined by equilibrium in vivo dialysis of faeces in patients with ulcerative colitis and healthy controls. Lauritsen, K., Hansen, J., Bytzer, P., Bukhave, K., Rask-Madsen, J. Gut (1984) [Pubmed]
  17. Long-term effects of withdrawal of bisphosphonate incadronate disodium (YM175) on bone mineral density, mass, structure, and turnover in the lumbar vertebrae of ovariectomized rats. Tamura, Y., Miyakoshi, N., Itoi, E., Abe, T., Kudo, T., Tsuchida, T., Kasukawa, Y., Sato, K. J. Bone Miner. Res. (2001) [Pubmed]
  18. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. Li, C., Mori, S., Li, J., Kaji, Y., Akiyama, T., Kawanishi, J., Norimatsu, H. J. Bone Miner. Res. (2001) [Pubmed]
  19. Maintaining bone mass by bisphosphonate incadronate disodium (YM175) sequential treatment after discontinuation of intermittent human parathyroid hormone (1-34) administration in ovariectomized rats. Takano, Y., Tanizawa, T., Mashiba, T., Endo, N., Nishida, S., Takahashi, H.E. J. Bone Miner. Res. (1996) [Pubmed]
  20. [1,4]Benzoxazine-2,3-diones as antiallergic agents. Loev, B., Jones, H., Brown, R.E., Huang, F.C., Khandwala, A., Leibowitz, M.J., Sonnino-Goldman, P. J. Med. Chem. (1985) [Pubmed]
  21. Pamidronate. A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Fitton, A., McTavish, D. Drugs (1991) [Pubmed]
  22. Thrombocytopenia associated with gold therapy. Observations on the mechanism of platelet destruction. Levin, H.A., McMillan, R., Tavassoli, M., Longmire, R.L., Yelenosky, R., Sacks, P.V. Am. J. Med. (1975) [Pubmed]
  23. Inhibition of HIV and virus replication by polysulphated polyxylan: HOE/BAY 946, a new antiviral compound. Biesert, L., Suhartono, H., Winkler, I., Meichsner, C., Helsberg, M., Hewlett, G., Klimetzek, V., Mölling, K., Schlumberger, H.D., Schrinner, E. AIDS (1988) [Pubmed]
  24. Long-term treatment of incadronate disodium accumulates microdamage but improves the trabecular bone microarchitecture in dog vertebra. Komatsubara, S., Mori, S., Mashiba, T., Ito, M., Li, J., Kaji, Y., Akiyama, T., Miyamoto, K., Cao, Y., Kawanishi, J., Norimatsu, H. J. Bone Miner. Res. (2003) [Pubmed]
  25. Methoxatin (PQQ) in guinea-pig neutrophils. Bishop, A., Paz, M.A., Gallop, P.M., Karnovsky, M.L. Free Radic. Biol. Med. (1994) [Pubmed]
  26. Singlet oxygen may mediate the ultraviolet A-induced synthesis of interstitial collagenase. Wlaschek, M., Briviba, K., Stricklin, G.P., Sies, H., Scharffetter-Kochanek, K. J. Invest. Dermatol. (1995) [Pubmed]
  27. Bilirubin chemistry, ionization and solubilization by bile salts. Ostrow, J.D., Celic, L. Hepatology (1984) [Pubmed]
  28. Effects of growth hormone replacement therapy on 1,25-dihydroxyvitamin D and calcium metabolism. Burstein, S., Chen, I.W., Tsang, R.C. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  29. Clodronate kinetics and bioavailability. Yakatan, G.J., Poynor, W.J., Talbert, R.L., Floyd, B.F., Slough, C.L., Ampulski, R.S., Benedict, J.J. Clin. Pharmacol. Ther. (1982) [Pubmed]
  30. Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast. Otaka, E., Higo, K., Osawa, S. Biochemistry (1982) [Pubmed]
  31. Radionuclide uptake studies of bone: a quantitative method of evaluating the response of patients with Paget's disease to diphosphonate therapy. Goldman, A.B., Braunstein, P., Wilkinson, D., Kammerman, S. Radiology. (1975) [Pubmed]
  32. Effects of disodium EDTA and calcium infusion on prolactin and thyrotropin responses to thyrotropin-releasing hormone in healthy man. Dudczak, R., Waldhäusl, W.K., Bratusch-Marrain, P. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  33. Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro. Okamoto, T., Yamagishi, S., Inagaki, Y., Amano, S., Takeuchi, M., Kikuchi, S., Ohno, S., Yoshimura, A. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  34. Calcium, carbonic anhydrase and gastric acid secretion. Puscas, I., Coltau, M., Baican, M., Domuta, G., Hecht, A. Physiological research / Academia Scientiarum Bohemoslovaca. (2001) [Pubmed]
  35. Activin release from bone coupled to bone resorption in organ culture of neonatal mouse calvaria. Sakai, R., Eto, Y., Hirafuji, M., Shinoda, H. Bone (2000) [Pubmed]
  36. The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in rats. Seedor, J.G., Quartuccio, H.A., Thompson, D.D. J. Bone Miner. Res. (1991) [Pubmed]
  37. Metal excretion and magnesium retention in patients with intermittent claudication treated with intravenous disodium EDTA. Guldager, B., Jørgensen, P.J., Grandjean, P. Clin. Chem. (1996) [Pubmed]
  38. Pharmacokinetic analysis of azelaic acid disodium salt. A proposed substrate for total parenteral nutrition. Bertuzzi, A., Gandolfi, A., Salinari, S., Mingrone, G., Arcieri-Mastromattei, E., Finotti, E., Greco, A.V. Clinical pharmacokinetics. (1991) [Pubmed]
  39. Improved detection of focal liver lesions at MR imaging: multicenter comparison of gadoxetic acid-enhanced MR images with intraoperative findings. Huppertz, A., Balzer, T., Blakeborough, A., Breuer, J., Giovagnoni, A., Heinz-Peer, G., Laniado, M., Manfredi, R.M., Mathieu, D.G., Mueller, D., Reimer, P., Robinson, P.J., Strotzer, M., Taupitz, M., Vogl, T.J. Radiology. (2004) [Pubmed]
  40. Pharmacokinetics and tolerance of a 24-h infusion of cefotetan disodium (with and without loading dose) in normal Caucasian volunteers. Adam, H.K., Houghton, H.L., Yates, R.A., Young, J., Donnelly, R.J. J. Antimicrob. Chemother. (1983) [Pubmed]
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