- Disodium 1-hydroxy-3-(1-pyrrolidinyl)-propylidene-1,1-bisphosphonate (EB-1053) is a potent inhibitor of bone resorption in vitro and in vivo. van der Pluijm, G., Binderup, L., Bramm, E., van der Wee-Pals, L., De Groot, H., Binderup, E., Löwik, C., Papapoulos, S. J. Bone Miner. Res. (1992)