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MeSH Review

Injections, Subcutaneous

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Disease relevance of Injections, Subcutaneous


Psychiatry related information on Injections, Subcutaneous


High impact information on Injections, Subcutaneous


Chemical compound and disease context of Injections, Subcutaneous


Biological context of Injections, Subcutaneous


Anatomical context of Injections, Subcutaneous


Associations of Injections, Subcutaneous with chemical compounds

  • Single subcutaneous injections of 50 microng of protamine zinc somatostatin raised preprandial blood glucose levels to 83+/-3 mg per deciliter for four to five days although preprandial hormone levels were unchanged [31].
  • Tumor hemorrhagic necrosis and regression failed to occur in mice that were given a subcutaneous injection of cortisone acetate or dexamethasone 12 h before being giving endotoxin [32].
  • However, mice given a single subcutaneous injection of 30 micrograms 115 kD glycoprotein in saline were completely protected against lethal challenges of HSV-I administered intraperitoneally or in the footpad 7 d after immunization [33].
  • Subcutaneous injection of p17 (a peptide consisting of 17 NH2-terminal aminoacids of MBP) in complete Freund's adjuvant (CFA) causes paralysis [34].
  • To test this possibility in vivo, rats (group 2) were given a 4% calcium (in the form of CaCO3) supplemented diet to increase delivery of Ca++ to the kidney and administered single daily subcutaneous injections of gentamicin, 100 mg/kg, for 10 d [35].

Gene context of Injections, Subcutaneous


Analytical, diagnostic and therapeutic context of Injections, Subcutaneous


  1. Response of thyrotropin-secreting pituitary adenomas to a long-acting somatostatin analogue. Comi, R.J., Gesundheit, N., Murray, L., Gorden, P., Weintraub, B.D. N. Engl. J. Med. (1987) [Pubmed]
  2. Chemoprevention of colon cancer by organoselenium compounds and impact of high- or low-fat diets. Reddy, B.S., Rivenson, A., El-Bayoumy, K., Upadhyaya, P., Pittman, B., Rao, C.V. J. Natl. Cancer Inst. (1997) [Pubmed]
  3. Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Mease, P.J., Goffe, B.S., Metz, J., VanderStoep, A., Finck, B., Burge, D.J. Lancet (2000) [Pubmed]
  4. Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. A phase I-II trial. Negrin, R.S., Haeuber, D.H., Nagler, A., Olds, L.C., Donlon, T., Souza, L.M., Greenberg, P.L. Ann. Intern. Med. (1989) [Pubmed]
  5. Hyperglycemia-induced teratogenesis is mediated by a functional deficiency of arachidonic acid. Goldman, A.S., Baker, L., Piddington, R., Marx, B., Herold, R., Egler, J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  6. Protection from ototoxicity of intraperitoneal gentamicin in guinea pig. Sinswat, P., Wu, W.J., Sha, S.H., Schacht, J. Kidney Int. (2000) [Pubmed]
  7. Effect of ventral tegmental 6-hydroxydopamine lesions on the locomotor stimulant action of nicotine in rats. Louis, M., Clarke, P.B. Neuropharmacology (1998) [Pubmed]
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  10. Fasting-induced down-regulation of NADPH-diaphorase in the magnocellular PVN of rats. Lee, J.Y., Kang, D.W., Kim, D.G., Jahng, J.W. Yonsei Med. J. (2004) [Pubmed]
  11. Association of protamine IgE and IgG antibodies with life-threatening reactions to intravenous protamine. Weiss, M.E., Nyhan, D., Peng, Z.K., Horrow, J.C., Lowenstein, E., Hirshman, C., Adkinson, N.F. N. Engl. J. Med. (1989) [Pubmed]
  12. Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men: an approach toward the development of a male contraceptive. Linde, R., Doelle, G.C., Alexander, N., Kirchner, F., Vale, W., Rivier, J., Rabin, D. N. Engl. J. Med. (1981) [Pubmed]
  13. Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Heaney, A.P., Fernando, M., Yong, W.H., Melmed, S. Nat. Med. (2002) [Pubmed]
  14. Melatonin increases oestrogen receptor binding activity of human breast cancer cells. Danforth, D.N., Tamarkin, L., Lippman, M.E. Nature (1983) [Pubmed]
  15. Pituitary receptor site blockade by a gonadotropin-releasing hormone antagonist in vivo: mechanism of action. Heber, D., Dodson, R., Swerdloff, R.S., Channabasavaiah, K., Stewart, J.M. Science (1982) [Pubmed]
  16. Use of an algorithm for administering subcutaneous heparin in the treatment of deep venous thrombosis. Prandoni, P., Bagatella, P., Bernardi, E., Girolami, B., Rossi, L., Scarano, L., Marchiori, A., Piccioli, A., Girolami, A. Ann. Intern. Med. (1998) [Pubmed]
  17. Biosynthetic human insulin improves postprandial glucose excursions in type I diabetics. Gulan, M., Gottesman, I.S., Zinman, B. Ann. Intern. Med. (1987) [Pubmed]
  18. Progressive ventricular remodeling in response to diffuse isoproterenol-induced myocardial necrosis in rats. Teerlink, J.R., Pfeffer, J.M., Pfeffer, M.A. Circ. Res. (1994) [Pubmed]
  19. Zoladex: a sustained-release, monthly luteinizing hormone-releasing hormone analogue for the treatment of advanced prostate cancer. Ahmann, F.R., Citrin, D.L., deHaan, H.A., Guinan, P., Jordan, V.C., Kreis, W., Scott, M., Trump, D.L. J. Clin. Oncol. (1987) [Pubmed]
  20. Repetitive cycles of cyclophosphamide, thiotepa, and carboplatin intensification with peripheral-blood progenitor cells and filgrastim in advanced breast cancer patients. Shapiro, C.L., Ayash, L., Webb, I.J., Gelman, R., Keating, J., Williams, L., Demetri, G., Clark, P., Elias, A., Duggan, D., Hayes, D., Hurd, D., Henderson, I.C. J. Clin. Oncol. (1997) [Pubmed]
  21. Blockage of ovulation in rats by inhibitory analogs of luteinizing hormones-releasing hormone. De la Cruz, A., Coy, D.H., Vilchez-Martinez, J.A., Arimura, A., Schelly, A.V. Science (1976) [Pubmed]
  22. Single subcutaneous injection of iothalamate sodium I 125 to measure glomerular filtration rate. Adefuin, P.Y., Gur, A., Siegel, N.J., Spencer, R.P., Hayslett, J.P. JAMA (1976) [Pubmed]
  23. Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis. Edelman, E.R., Karnovsky, M.J. Circulation (1994) [Pubmed]
  24. Expression of c-Fos immunoreactivity in transmitter-characterized neurons after stress. Ceccatelli, S., Villar, M.J., Goldstein, M., Hökfelt, T. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  25. Pharmacokinetics and effects of recombinant human erythropoietin after intravenous and subcutaneous injections in healthy volunteers. McMahon, F.G., Vargas, R., Ryan, M., Jain, A.K., Abels, R.I., Perry, B., Smith, I.L. Blood (1990) [Pubmed]
  26. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. Dancescu, M., Rubio-Trujillo, M., Biron, G., Bron, D., Delespesse, G., Sarfati, M. J. Exp. Med. (1992) [Pubmed]
  27. Congenital osteoclast deficiency in osteopetrotic (op/op) mice is cured by injections of macrophage colony-stimulating factor. Kodama, H., Yamasaki, A., Nose, M., Niida, S., Ohgame, Y., Abe, M., Kumegawa, M., Suda, T. J. Exp. Med. (1991) [Pubmed]
  28. Oligonucleotides antisense to the interleukin 1 receptor mRNA block the effects of interleukin 1 in cultured murine and human fibroblasts and in mice. Burch, R.M., Mahan, L.C. J. Clin. Invest. (1991) [Pubmed]
  29. Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I. Briner, T.J., Kuo, M.C., Keating, K.M., Rogers, B.L., Greenstein, J.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  30. Antipain and leupeptin restrict uterine DNA synthesis and function in mice. Katz, J., Troll, W., Adler, S.W., Levitz, M. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  31. Hypoglycemia of infancy and nesidioblastosis. Studies with somatostatin. Hirsch, H.J., Loo, S., Evans, N., Crigler, J.F., Filler, R.M., Gabbay, K.H. N. Engl. J. Med. (1977) [Pubmed]
  32. Glucocorticoid-mediated inhibition of endotoxin-induced intratumor tumor necrosis factor production and tumor hemorrhagic necrosis and regression. North, R.J., Havell, E.A. J. Exp. Med. (1989) [Pubmed]
  33. Helper T cells induced by an immunopurified herpes simplex virus type I (HSV-I) 115 kilodalton glycoprotein (gB) protect mice against HSV-I infection. Chan, W.L., Lukig, M.L., Liew, F.Y. J. Exp. Med. (1985) [Pubmed]
  34. Tolerance induction and autoimmune encephalomyelitis amelioration after administration of myelin basic protein-derived peptide. Marusić, S., Tonegawa, S. J. Exp. Med. (1997) [Pubmed]
  35. Calcium is a competitive inhibitor of gentamicin-renal membrane binding interactions and dietary calcium supplementation protects against gentamicin nephrotoxicity. Humes, H.D., Sastrasinh, M., Weinberg, J.M. J. Clin. Invest. (1984) [Pubmed]
  36. Ligation of CD40 induces the expression of vascular endothelial growth factor by endothelial cells and monocytes and promotes angiogenesis in vivo. Melter, M., Reinders, M.E., Sho, M., Pal, S., Geehan, C., Denton, M.D., Mukhopadhyay, D., Briscoe, D.M. Blood (2000) [Pubmed]
  37. Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. LaBelle, J.L., Hanke, C.A., Blazar, B.R., Truitt, R.L. Blood (2002) [Pubmed]
  38. Transcription factor ATF2 cooperates with v-Jun to promote growth factor-independent proliferation in vitro and tumor formation in vivo. Huguier, S., Baguet, J., Perez, S., van Dam, H., Castellazzi, M. Mol. Cell. Biol. (1998) [Pubmed]
  39. Role of gastrointestinal hormones in postprandial reduction of bone resorption. Henriksen, D.B., Alexandersen, P., Bjarnason, N.H., Vilsbøll, T., Hartmann, B., Henriksen, E.E., Byrjalsen, I., Krarup, T., Holst, J.J., Christiansen, C. J. Bone Miner. Res. (2003) [Pubmed]
  40. Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. Anders, H.J., Belemezova, E., Eis, V., Segerer, S., Vielhauer, V., Perez de Lema, G., Kretzler, M., Cohen, C.D., Frink, M., Horuk, R., Hudkins, K.L., Alpers, C.E., Mampaso, F., Schlöndorff, D. J. Am. Soc. Nephrol. (2004) [Pubmed]
  41. Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts. Couillard, S., Labrie, C., Bélanger, A., Candas, B., Pouliot, F., Labrie, F. J. Natl. Cancer Inst. (1998) [Pubmed]
  42. Association of insulin pump therapy with raised serum amyloid A in type I diabetes mellitus. Brownlee, M., Vlassara, H., Cerami, A., Martin, T.R., Li, J.J., McAdam, K.P. Lancet (1984) [Pubmed]
  43. Postoperative fondaparinux versus postoperative enoxaparin for prevention of venous thromboembolism after elective hip-replacement surgery: a randomised double-blind trial. Turpie, A.G., Bauer, K.A., Eriksson, B.I., Lassen, M.R. Lancet (2002) [Pubmed]
  44. Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. van der Lely, A.J., Hutson, R.K., Trainer, P.J., Besser, G.M., Barkan, A.L., Katznelson, L., Klibanski, A., Herman-Bonert, V., Melmed, S., Vance, M.L., Freda, P.U., Stewart, P.M., Friend, K.E., Clemmons, D.R., Johannsson, G., Stavrou, S., Cook, D.M., Phillips, L.S., Strasburger, C.J., Hackett, S., Zib, K.A., Davis, R.J., Scarlett, J.A., Thorner, M.O. Lancet (2001) [Pubmed]
  45. In vivo biologic effects of PIXY321, a synthetic hybrid protein of recombinant human granulocyte-macrophage colony-stimulating factor and interleukin-3 in cancer patients with normal hematopoiesis: a phase I study. Vadhan-Raj, S., Broxmeyer, H.E., Andreeff, M., Bandres, J.C., Buescher, E.S., Benjamin, R.S., Papadopoulos, N.E., Burgess, A., Patel, S., Plager, C., Hittelman, W.N., McAlister, I., Garrison, L., Williams, D.E. Blood (1995) [Pubmed]
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