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Chemical Compound Review

leuhistin     (2R,3S)-3-amino-2-hydroxy-2- (3H-imidazol-4...

Synonyms: Leuhistine, SureCN12609365, LS-78878, AC1L2YI6, C11H19N3O3, ...
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High impact information on leuhistin

  • Inhibition of CD13 aminopeptidase activity by nontoxic concentrations of leuhistin modestly decreased the migration of CL1-5 cells [1].
  • The combination of spinorphin and leuhistin (2 mg/kg, i.v.), a specific inhibitor of aminopeptidase N (APN), markedly suppressed the PMN accumulation induced by carrageenan (1.11+/-0.17 x 10[6] cells, 88% inhibition compared to the saline-treated group, n=5, P<0.01) [2].
  • Each is inhibited competitively by amastatin (C. elegans IC50 = 0.46 microM; P. redivivus IC50 = 15.90 microM) and non-competitively by leuhistin (C. elegans IC50 = 3.00 microM; P. redivivus IC50 = 37.35 microM) [3].

Gene context of leuhistin

  • Leuhistin inhibits AP-M strongly and it also inhibits AP-A and AP-B weakly [4].


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