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Chemical Compound Review:

leuhistin (2R,3S)-3-amino-2-hydroxy-2- (3H-imidazol-4...

Synonyms: Leuhistine, SureCN12609365, LS-78878, AC1L2YI6, C11H19N3O3, ...

Yamamoto, Y. et al., Masler, E.P., Chang, Y.W. et al., Aoyagi, T. et al.

Yamamoto, Kanazawa, Shimamura, Ueki, Hazato, Masler,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on leuhistin

Inhibition of CD13 aminopeptidase activity by nontoxic concentrations of leuhistin modestly decreased the migration of CL1-5 cells [1].
The combination of spinorphin and leuhistin (2 mg/kg, i.v.), a specific inhibitor of aminopeptidase N (APN), markedly suppressed the PMN accumulation induced by carrageenan (1.11+/-0.17 x 10[6] cells, 88% inhibition compared to the saline-treated group, n=5, P<0.01) [2].
Each is inhibited competitively by amastatin (C. elegans IC50 = 0.46 microM; P. redivivus IC50 = 15.90 microM) and non-competitively by leuhistin (C. elegans IC50 = 3.00 microM; P. redivivus IC50 = 37.35 microM) [3].

Gene context of leuhistin

Leuhistin inhibits AP-M strongly and it also inhibits AP-A and AP-B weakly [4].

References

CD13 (aminopeptidase N) can associate with tumor-associated antigen L6 and enhance the motility of human lung cancer cells. Chang, Y.W., Chen, S.C., Cheng, E.C., Ko, Y.P., Lin, Y.C., Kao, Y.R., Tsay, Y.G., Yang, P.C., Wu, C.W., Roffler, S.R. Int. J. Cancer (2005) [Pubmed]
Inhibitory action of spinorphin, an endogenous regulator of enkephalin-degrading enzymes, on carrageenan-induced polymorphonuclear neutrophil accumulation in mouse air-pouches. Yamamoto, Y., Kanazawa, H., Shimamura, M., Ueki, M., Hazato, T. Life Sci. (1998) [Pubmed]
Aminopeptidases in Caenorhabditis elegans and Panagrellus redivivus: detection using peptide and non-peptide substrates. Masler, E.P. J. Helminthol. (2002) [Pubmed]
Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. I. Taxonomy, production, isolation, physico-chemical properties and biological activities. Aoyagi, T., Yoshida, S., Matsuda, N., Ikeda, T., Hamada, M., Takeuchi, T. J. Antibiot. (1991) [Pubmed]

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