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Gene Review

ANPEP  -  alanyl (membrane) aminopeptidase

Homo sapiens

Synonyms: AP-M, AP-N, APN, Alanyl aminopeptidase, Aminopeptidase M, ...
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Disease relevance of ANPEP


Psychiatry related information on ANPEP

  • Moreover, APN inhibitors and mutations in the catalytic site had no obvious effect on permissiveness for virus, thus providing evidence that the APN enzymatic activity is not involved in the process of infection [6].
  • After a short period (48 h) of wakefulness and feeding following 10 days of starvation during the hibernation period, the activities of the disaccharidases and of aminopeptidase N returned to values measured in active animals [7].

High impact information on ANPEP


Chemical compound and disease context of ANPEP


Biological context of ANPEP


Anatomical context of ANPEP


Associations of ANPEP with chemical compounds

  • Among the herein described and evaluated compounds, the 2',3-dinitroflavone-8-acetic acid (19b) proved to be the most efficient and exhibited an IC(50) of 25 microM which is 2.5 times higher than that of bestatin (1), the natural known inhibitor of APN/CD13 [22].
  • Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13 [22].
  • The link between met-enkephalin-induced down-regulation of APN activity and the release of superoxide anion [23].
  • DEX strongly increased NEP and APN expression and activity, both in the absence and in the presence of cytokines [24].
  • Aminopeptidase-P removes the N-terminal tyrosine from PYY, but the intact peptide is not a substrate for aminopeptidase-N [25].

Physical interactions of ANPEP

  • Alanine methyl ketone-Sepharose (AMK-Sepharose) is introduced as affinity support for the purification of a bacterial alanyl aminopeptidase (AAP) from a membrane protein extract and Arginine-Agarose as support for the preparation of a membrane-bound proteinase of myeloma cells (MP-1) [26].
  • Aminopeptidase N has been reported to be a Bacillus thuringiensis (Bt) Cry1A toxin-binding protein in several lepidopteran insects. cDNAs of aminopeptidase-like proteins from both Bt-susceptible RC688s and Bt-resistant HD198r strains of the Indianmeal moth, Plodia interpunctella, were cloned and sequenced [27].

Co-localisations of ANPEP


Regulatory relationships of ANPEP


Other interactions of ANPEP


Analytical, diagnostic and therapeutic context of ANPEP


  1. Biological significance of aminopeptidase N/CD13 in thyroid carcinomas. Kehlen, A., Lendeckel, U., Dralle, H., Langner, J., Hoang-Vu, C. Cancer Res. (2003) [Pubmed]
  2. Human cytomegalovirus infection downregulates expression of the cellular aminopeptidases CD10 and CD13. Phillips, A.J., Tomasec, P., Wang, E.C., Wilkinson, G.W., Borysiewicz, L.K. Virology (1998) [Pubmed]
  3. Functional and phenotypic upregulation of CD13/aminopeptidase-N on precursor-B acute lymphoblastic leukemia after in vitro stimulation. Makrynikola, V., Favaloro, E.J., Browning, T., Bianchi, A., Bradstock, K.F. Exp. Hematol. (1995) [Pubmed]
  4. Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue. Bogenrieder, T., Finstad, C.L., Freeman, R.H., Papandreou, C.N., Scher, H.I., Albino, A.P., Reuter, V.E., Nanus, D.M. Prostate (1997) [Pubmed]
  5. Neutral endopeptidase/CD10 and aminopeptidase N/CD13 gene expression as a prognostic factor in non-small cell lung cancer. Tokuhara, T., Adachi, M., Hashida, H., Ishida, H., Taki, T., Higashiyama, M., Kodama, K., Tachibana, S., Sasaki, S., Miyake, M. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai zasshi. (2001) [Pubmed]
  6. Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site. Delmas, B., Gelfi, J., Kut, E., Sjöström, H., Noren, O., Laude, H. J. Virol. (1994) [Pubmed]
  7. Adaptation of intestinal enzymes to seasonal and dietary changes in a hibernator: the European hamster (Cricetus cricetus). Galluser, M., Raul, F., Canguilhem, B. J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. (1988) [Pubmed]
  8. Deficiency of a granulocyte-membrane glycoprotein (gp150) in a boy with recurrent bacterial infections. Arnaout, M.A., Pitt, J., Cohen, H.J., Melamed, J., Rosen, F.S., Colten, H.R. N. Engl. J. Med. (1982) [Pubmed]
  9. Human aminopeptidase N is a receptor for human coronavirus 229E. Yeager, C.L., Ashmun, R.A., Williams, R.K., Cardellichio, C.B., Shapiro, L.H., Look, A.T., Holmes, K.V. Nature (1992) [Pubmed]
  10. Characterization of a novel Hodgkin cell line, HD-MyZ, with myelomonocytic features mimicking Hodgkin's disease in severe combined immunodeficient mice. Bargou, R.C., Mapara, M.Y., Zugck, C., Daniel, P.T., Pawlita, M., Döhner, H., Dörken, B. J. Exp. Med. (1993) [Pubmed]
  11. Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells. Mishima, Y., Matsumoto-Mishima, Y., Terui, Y., Katsuyama, M., Yamada, M., Mori, M., Ishizaka, Y., Ikeda, K., Watanabe, J., Mizunuma, N., Hayasawa, H., Hatake, K. J. Natl. Cancer Inst. (2002) [Pubmed]
  12. Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150). Look, A.T., Peiper, S.C., Rebentisch, M.B., Ashmun, R.A., Roussel, M.F., Lemons, R.S., Le Beau, M.M., Rubin, C.M., Sherr, C.J. J. Clin. Invest. (1986) [Pubmed]
  13. Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae. Nomura, R., Kiyota, A., Suzaki, E., Kataoka, K., Ohe, Y., Miyamoto, K., Senda, T., Fujimoto, T. J. Virol. (2004) [Pubmed]
  14. Ectopeptidases in tumour biology: a review. Carl-McGrath, S., Lendeckel, U., Ebert, M., Röcken, C. Histol. Histopathol. (2006) [Pubmed]
  15. Triggering endogenous immunosuppressive mechanisms by combined targeting of Dipeptidyl peptidase IV (DPIV/CD26) and Aminopeptidase N (APN/ CD13) - A novel approach for the treatment of inflammatory bowel disease. Bank, U., Heimburg, A., Helmuth, M., Stefin, S., Lendeckel, U., Reinhold, D., Faust, J., Fuchs, P., Sens, B., Neubert, K., T??ger, M., Ansorge, S. Int. Immunopharmacol. (2006) [Pubmed]
  16. Addition of a single glycosylation site to hAPN blocks human coronavirus-229E receptor activity. Wentworth, D.E., Holmes, K.V. Adv. Exp. Med. Biol. (2001) [Pubmed]
  17. Mapping of the CYP1A1, SSTR1 and TTF1 genes to pig chromosome 7q refines the porcine-human comparative map. Marklund, S., Tuggle, C.K., Rothschild, M.F. Anim. Genet. (2000) [Pubmed]
  18. Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13. Riemann, D., Kehlen, A., Langner, J. Clin. Exp. Immunol. (1995) [Pubmed]
  19. Rapid increases in the membrane expression of neutral endopeptidase (CD10), aminopeptidase N (CD13), tyrosine phosphatase (CD45), and Fc gamma-RIII (CD16) upon stimulation of human peripheral leukocytes with human C5a. Werfel, T., Sonntag, G., Weber, M.H., Götze, O. J. Immunol. (1991) [Pubmed]
  20. Ectoenzyme regulation by phenotypically distinct fibroblast sub-populations isolated from the human mammary gland. Atherton, A.J., O'Hare, M.J., Buluwela, L., Titley, J., Monaghan, P., Paterson, H.F., Warburton, M.J., Gusterson, B.A. J. Cell. Sci. (1994) [Pubmed]
  21. Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains. Riemann, D., Hansen, G.H., Niels-Christiansen, L., Thorsen, E., Immerdal, L., Santos, A.N., Kehlen, A., Langner, J., Danielsen, E.M. Biochem. J. (2001) [Pubmed]
  22. Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13. Bauvois, B., Puiffe, M.L., Bongui, J.B., Paillat, S., Monneret, C., Dauzonne, D. J. Med. Chem. (2003) [Pubmed]
  23. The link between met-enkephalin-induced down-regulation of APN activity and the release of superoxide anion. Marotti, T., Balog, T., Munić, V., Sobocanec, S., Abramić, M. Neuropeptides (2000) [Pubmed]
  24. Cytokines and glucocorticoids modulate human bronchial epithelial cell peptidases. van der Velden, V.H., Naber, B.A., van der Spoel, P., Hoogsteden, H.C., Versnel, M.A. Cytokine (1998) [Pubmed]
  25. Processing and metabolism of peptide-YY: pivotal roles of dipeptidylpeptidase-IV, aminopeptidase-P, and endopeptidase-24.11. Medeiros, M.D., Turner, A.J. Endocrinology (1994) [Pubmed]
  26. Purification of soluble and membrane-bound proteases with substrate-analogous inhibitors by affinity chromatography. Jahreis, G., Peters, K., Kirschke, H. J. Biochem. Biophys. Methods (2001) [Pubmed]
  27. cDNAs of aminopeptidase-like protein genes from Plodia interpunctella strains with different susceptibilities to Bacillus thuringiensis toxins. Zhu, Y.C., Kramer, K.J., Oppert, B., Dowdy, A.K. Insect Biochem. Mol. Biol. (2000) [Pubmed]
  28. Involvement of insulin-regulated aminopeptidase and/or aminopeptidase N in the angiotensin IV-induced effect on dopamine release in the striatum of the rat. Stragier, B., Demaegdt, H., De Bundel, D., Smolders, I., Sarre, S., Vauquelin, G., Ebinger, G., Michotte, Y., Vanderheyden, P. Brain Res. (2007) [Pubmed]
  29. Epidermal growth factor upregulates aminopeptidase N and 5'-nucleotidase in human glomerular mesangial cells. Stefanović, V., Vlahović, P., Mitić-Zlatković, M. Kidney Blood Press. Res. (1998) [Pubmed]
  30. Receptor interference mediated by the envelope glycoproteins of various HIV-1 and HIV-2 isolates. Martin, R.A., Nayak, D.P. Virus Res. (1996) [Pubmed]
  31. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation. Reinhold, D., Biton, A., Pieper, S., Lendeckel, U., Faust, J., Neubert, K., Bank, U., T??ger, M., Ansorge, S., Brocke, S. Int. Immunopharmacol. (2006) [Pubmed]
  32. Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. Varona, A., Blanco, L., López, J.I., Gil, J., Agirregoitia, E., Irazusta, J., Larrinaga, G. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  33. Ectopeptidases are differentially expressed in hepatocellular carcinomas. Röcken, C., Carl-McGrath, S., Gräntzdörffer, I., Mantke, R., Roessner, A., Lendeckel, U. Int. J. Oncol. (2004) [Pubmed]
  34. Differential expression of aminopeptidase-N on human ovarian granulosa and theca cells. Fujiwara, H., Maeda, M., Imai, K., Fukuoka, M., Yasuda, K., Horie, K., Takakura, K., Taii, S., Mori, T. J. Clin. Endocrinol. Metab. (1992) [Pubmed]
  35. Human endometrial stromal cells and decidual cells express cluster of differentiation (CD) 13 antigen/aminopeptidase N and CD10 antigen/neutral endopeptidase. Imai, K., Maeda, M., Fujiwara, H., Okamoto, N., Kariya, M., Emi, N., Takakura, K., Kanzaki, H., Mori, T. Biol. Reprod. (1992) [Pubmed]
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