Chemical Compound Review:
Amastatin (2S)-2-[[(2S)-2-[[(2S)-2- [[(2S,3R)-3-amino...
Synonyms:
CHEMBL28650, CHEBI:2624, FT-0622252, AC1L97I5, C01552, ...
Hirasawa,
Kombian,
Pittman,
Kawabata,
Kuroda,
Nishida,
Nagata,
Sakaguchi,
Kawao,
Nishikawa,
Arizono,
Kawai,
Kawabata,
Kuroda,
Nagata,
Kawao,
Masuko,
Nishikawa,
Kawai,
Kawabata,
Kanke,
Yonezawa,
Ishiki,
Saka,
Kabeya,
Sekiguchi,
Kubo,
Kuroda,
Iwaki,
Katsura,
Plevin,
Gesualdo,
Ranieri,
Monno,
Rossiello,
Colucci,
Semeraro,
Grandaliano,
Schena,
Ursi,
Cerullo,
- Biochemical and functional characterization of aminopeptidase N expressed by human melanoma cells. Menrad, A., Speicher, D., Wacker, J., Herlyn, M. Cancer Res. (1993)
- The slow, tight binding of bestatin and amastatin to aminopeptidases. Wilkes, S.H., Prescott, J.M. J. Biol. Chem. (1985)
- Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes. Aoyagi, T., Tobe, H., Kojima, F., Hamada, M., Takeuchi, T., Umezawa, H. J. Antibiot. (1978)
- Effect of various compounds on enkephalin hydrolysis by an aminopeptidase from the thermophiles Thermomonospora fusca ATCC 27730 and Thermus thermophilus ATCC 27634. Weiss, B., Hui, M., Lajtha, A. Res. Commun. Chem. Pathol. Pharmacol. (1983)
- Identification and characterization of brush-border membrane-bound neutral metalloendopeptidases from rat small intestine. Song, I.S., Yoshioka, M., Erickson, R.H., Miura, S., Guan, D., Kim, Y.S. Gastroenterology (1986)
- Functional separation of dipeptide transport and hydrolysis in kidney brush border membrane vesicles. Daniel, H., Adibi, S.A. FASEB J. (1994)
- Function of neutral endopeptidase on the cell membrane of human neutrophils. Painter, R.G., Dukes, R., Sullivan, J., Carter, R., Erdös, E.G., Johnson, A.R. J. Biol. Chem. (1988)
- Kinin metabolism in human nasal secretions during experimentally induced allergic rhinitis. Proud, D., Baumgarten, C.R., Naclerio, R.M., Ward, P.E. J. Immunol. (1987)
- Oxytocin retrogradely inhibits evoked, but not miniature, EPSCs in the rat supraoptic nucleus: role of N- and P/Q-type calcium channels. Hirasawa, M., Kombian, S.B., Pittman, Q.J. J. Physiol. (Lond.) (2001)
- X-ray crystallographic determination of the structure of bovine lens leucine aminopeptidase complexed with amastatin: formulation of a catalytic mechanism featuring a gem-diolate transition state. Kim, H., Lipscomb, W.N. Biochemistry (1993)
- Potent and metabolically stable agonists for protease-activated receptor-2: evaluation of activity in multiple assay systems in vitro and in vivo. Kawabata, A., Kanke, T., Yonezawa, D., Ishiki, T., Saka, M., Kabeya, M., Sekiguchi, F., Kubo, S., Kuroda, R., Iwaki, M., Katsura, K., Plevin, R. J. Pharmacol. Exp. Ther. (2004)
- Role of aminopeptidase activity in the regulation of the pressor activity of circulating angiotensins. Ahmad, S., Ward, P.E. J. Pharmacol. Exp. Ther. (1990)
- Influence of aminopeptidase inhibitors on brain angiotensin metabolism and drinking in rats. Wright, J.W., Quirk, W.S., Hanesworth, J.M., Harding, J.W. Brain Res. (1988)
- Drug metabolism in the nasal mucosa. Sarkar, M.A. Pharm. Res. (1992)
- The aminopeptidase activity in the human T-cell lymphoma line (Jurkat) is not at the cell surface and is not aminopeptidase N (CD-13). Murray, H., Turner, A.J., Kenny, A.J. Biochem. J. (1994)
- The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N. Matsas, R., Stephenson, S.L., Hryszko, J., Kenny, A.J., Turner, A.J. Biochem. J. (1985)
- Characterization of somatostatin receptors in guinea-pig isolated ileum, vas deferens and right atrium. Feniuk, W., Dimech, J., Humphrey, P.P. Br. J. Pharmacol. (1993)
- Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosa. Wyatt, M.A., Jarvie, E., Feniuk, W., Humphrey, P.P. Br. J. Pharmacol. (1996)
- Proctolin degradation by membrane peptidases from nervous tissues of the desert locust (Schistocerca gregaria). Isaac, R.E. Biochem. J. (1987)
- The hydrolysis of alpha-human atrial natriuretic peptide by pig kidney microvillar membranes is initiated by endopeptidase-24.11. Stephenson, S.L., Kenny, A.J. Biochem. J. (1987)
- N-terminal degradation of low molecular weight opioid peptides in human cerebrospinal fluid. Benter, I.F., Hirsh, E.M., Tuchman, A.J., Ward, P.E. Biochem. Pharmacol. (1990)
- Receptor-mediated induction of aminopeptidase A (APA) of human glomerular epithelial cells (HGEC) by glucocorticoids. Stefanovic, V., Vlahovic, P., Ardaillou, N., Ardaillou, R. FEBS Lett. (1991)
- Vasopressin and amastatin induce V(1)-receptor-mediated suppression of excitatory transmission in the rat parabrachial nucleus. Chen, X., Pittman, Q.J. J. Neurophysiol. (1999)
- Bradykinin degrading activity in cultured human endothelial cells. Graf, K., Gräfe, M., Auch-Schwelk, W., Baumgarten, C.R., Bossaller, C., Fleck, E. J. Cardiovasc. Pharmacol. (1992)
- Protease-activated receptor-2 (PAR-2) in the pancreas and parotid gland: Immunolocalization and involvement of nitric oxide in the evoked amylase secretion. Kawabata, A., Kuroda, R., Nishida, M., Nagata, N., Sakaguchi, Y., Kawao, N., Nishikawa, H., Arizono, N., Kawai, K. Life Sci. (2002)
- Angiotensin IV stimulates plasminogen activator inhibitor-1 expression in proximal tubular epithelial cells. Gesualdo, L., Ranieri, E., Monno, R., Rossiello, M.R., Colucci, M., Semeraro, N., Grandaliano, G., Schena, F.P., Ursi, M., Cerullo, G. Kidney Int. (1999)
- In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. Kawabata, A., Kuroda, R., Nagata, N., Kawao, N., Masuko, T., Nishikawa, H., Kawai, K. Br. J. Pharmacol. (2001)
- Aerosolized neutral endopeptidase reverses ozone-induced airway hyperreactivity to substance P. Murlas, C.G., Lang, Z., Williams, G.J., Chodimella, V. J. Appl. Physiol. (1992)
- Intracisternal neutral endopeptidase-24.11 inhibitors produce inhibition in gastric acid output: independence from opiate, bombesin, or neurotensin-mediated mechanisms. Stephens, R.L., LePard, K.J., Mohammed, J.R., Ward, P.E. Regul. Pept. (1993)
- Amastatin potentiates drinking elicited by osmotic stimuli: evidence for peptidergic mediation of intracellular dehydration-induced thirst. Sullivan, M.J., Johnson, A.K. Brain Res. (1992)