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Chemical Compound Review

E-3710 citrate     N,N-dimethyl-2-[(2- methylpyrazol-3-yl)...

Synonyms: SureCN1649170, LS-183000, E-4018, E-4960, E-4961, ...
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Disease relevance of E-4018


High impact information on E-4018

  • There was no significant difference between any of the E-4018 treatment groups and placebo in terms of the AUC for VAS pain scores over time [2].
  • 1. The pharmacokinetics of cizolirtine citrate, a new analgesic compound, were studied in the rat and dog following single oral and intravenous doses [3].

Anatomical context of E-4018


Analytical, diagnostic and therapeutic context of E-4018

  • Validation of GC method to measure a new analgesic (E-4018) in biological samples. Comparison between HPLC and GC method [4].


  1. Comparison of cizolirtine citrate and metamizol sodium in the treatment of adult acute renal colic: a randomized, double-blind, clinical pilot study. Pavlik, I., Suchy, J., Pacík, D., Bokr, R., Sust, M., Villoria, J., Abadías, M. Clinical therapeutics. (2004) [Pubmed]
  2. Dose response and safety of cizolirtine citrate (E-4018) in patients with pain following extraction of third molars. Matthew, I.R., Ogden, G.R., Frame, J.W., Wight, A.J. Current medical research and opinion. (2000) [Pubmed]
  3. Absorption, distribution, metabolism and excretion of cizolirtine, a new analgesic compound, in rat and dog. Martínez, L., Serafini, M.T., Pretel, M.J., Garcia-Soret, A., Moragon, T., Puig, S. Xenobiotica (1999) [Pubmed]
  4. Validation of GC method to measure a new analgesic (E-4018) in biological samples. Comparison between HPLC and GC method. Caturla, M.C., Salomo, J., Soler, M., Martinez, L., Roser, R. Journal of pharmaceutical and biomedical analysis. (1991) [Pubmed]
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