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Chemical Compound Review

Analgin     sodium[(1,5-dimethyl-3-oxo-2- phenyl...

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Disease relevance of KBioSS_002161


Psychiatry related information on KBioSS_002161


High impact information on KBioSS_002161

  • P-selectin glycoprotein ligand-1 (PSGL-1) is the high affinity counter-receptor for P-selectin on myeloid cells (Sako, D., Chang, X.J., Barone, K.M., Vachino, G., White, H.M., Shaw, G., Veldman, G.M., Bean, K.M., Ahern, T.J., Furie, B., Cumming, D. A., and Larsen, G. R. (1993) Cell 75, 1179-1186) [8].
  • Dipyrone (metamizole) metabolites interfere with HPLC analysis of plasma catecholamines but not with the determination of urinary catecholamines [9].
  • The NSAID dipyrone (metamizol) has been shown to engage opioidergic circuits at the PAG, the NRM and the spinal cord, but it is unknown whether this can be generalized to typical NSAIDs and to systemic administration [10].
  • In the first part of this study, we analyzed the effectiveness of buprenorphine, tramadol, ketorolac and metamizol in the clinical setting, where the placebo effect was completely eliminated by means of hidden infusions [11].
  • The opioid receptor antagonist naloxone completely blocked morphine induction of GPDH but had no effect on GPDH induction by noxious heat stimulation or metamizol treatment, implicating different mechanisms of GPDH induction [12].

Chemical compound and disease context of KBioSS_002161


Biological context of KBioSS_002161

  • In the patients exposed to metamizol, an A24-B7 haplotype was found with a frequency higher than that in the non-exposed patients and the reference group (p < 0.05) [2].
  • Only at concentrations above 100 microM, well over the pharmacological range, metamizol-induced apoptosis in about 30% of the HL60 promyelocytes, while HL60-granulocytic terminally differentiated cells were more resistant to this apoptotic action [18].
  • When the effects of metamizol were compared with those of acetylsalicylic acid (ASA) and diclofenac on cell viability, at equivalent concentrations used in analgesic and antipyretic therapy (75 microM for metamizol, and ASA and 3 microM for diclofenac) their apoptotic effects were similar [18].
  • The IC50 values of metamizol for cyclooxygenase-1 in intact bovine aortic endothelial cells (BAEC) cells and human platelets were 1730 +/- 150 microg/ml and 486 +/- 56 microg/ml, respectively [19].
  • For a 1 degrees C temperature decrease, the energy expenditure index increased by 5% with external cooling and decreased by 7% and 8% in the metamizol and propacetamol groups, respectively [20].

Anatomical context of KBioSS_002161


Associations of KBioSS_002161 with other chemical compounds


Gene context of KBioSS_002161


Analytical, diagnostic and therapeutic context of KBioSS_002161


  1. Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Frederich, R.C., Löllmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B.B., Lowell, B.B., Flier, J.S. J. Clin. Invest. (1995) [Pubmed]
  2. Genetic factors and risk of agranulocytosis from metamizol. Vlahov, V., Bacracheva, N., Tontcheva, D., Naumova, E., Mavrudieva, M., Ilieva, P., Michailova, A. Pharmacogenetics (1996) [Pubmed]
  3. Intramuscular injection of tumor necrosis factor-alpha induces muscle hyperalgesia in rats. Schäfers, M., Sorkin, L.S., Sommer, C. Pain (2003) [Pubmed]
  4. N-nitrosation of medicinal drugs catalysed by bacteria from human saliva and gastro-intestinal tract, including Helicobacter pylori. Ziebarth, D., Spiegelhalder, B., Bartsch, H. Carcinogenesis (1997) [Pubmed]
  5. Intravenous metamizol (Dipyrone) in acute migraine treatment and in episodic tension-type headache--a placebo-controlled study. Bigal, M.E., Bordini, C.A., Speciali, J.G. Cephalalgia : an international journal of headache. (2001) [Pubmed]
  6. A rapid method for evaluation of analgesic and anti-inflammatory activity in rats. Rao, C.S., Muralidhar, N., Naidu, M.U., Junnarkar, A.Y., Singh, P.P. Indian J. Exp. Biol. (1991) [Pubmed]
  7. Pyrazolones in the treatment of postoperative pain. Hempel, V. Agents Actions Suppl. (1986) [Pubmed]
  8. P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells. Vachino, G., Chang, X.J., Veldman, G.M., Kumar, R., Sako, D., Fouser, L.A., Berndt, M.C., Cumming, D.A. J. Biol. Chem. (1995) [Pubmed]
  9. Dipyrone (metamizole) metabolites interfere with HPLC analysis of plasma catecholamines but not with the determination of urinary catecholamines. Müssig, K., Pfäfflin, A., Häring, H.U., Schleicher, E.D. Clin. Chem. (2006) [Pubmed]
  10. Induction of opioid tolerance by lysine-acetylsalicylate in rats. Pernia-Andrade, A.J., Tortorici, V., Vanegas, H. Pain (2004) [Pubmed]
  11. Response variability to analgesics: a role for non-specific activation of endogenous opioids. Amanzio, M., Pollo, A., Maggi, G., Benedetti, F. Pain (2001) [Pubmed]
  12. Induction of glycerol phosphate dehydrogenase gene expression during seizure and analgesia. Link, W.A., Kauselmann, G., Mellström, B., Kuhl, D., Naranjo, J.R. J. Neurochem. (2000) [Pubmed]
  13. Efficacy and safety of metamizol vs. acetylsalicylic acid in patients with moderate episodic tension-type headache: a randomized, double-blind, placebo- and active-controlled, multicentre study. Martínez-Martín, P., Raffaelli, E., Titus, F., Despuig, J., Fragoso, Y.D., Díez-Tejedor, E., Liaño, H., Leira, R., Cornet, M.E., van Toor, B.S., Cámara, J., Peil, H., Vix, J.M., Ortiz, P. Cephalalgia : an international journal of headache. (2001) [Pubmed]
  14. Demonstration of drug-dependent antibodies in two patients with neutrophenia and successful treatment with granulocyte-colony-stimulating factor. Meyer, O., Gaedicke, G., Salama, A. Transfusion (1999) [Pubmed]
  15. Noramidopyrine (Metamizol) and acute interstitial nephritis. Berruti, V., Salvidio, G., Saffioti, S., Pontremoli, R., Arnone, O., Giannoni, M., Garibotto, G. Nephrol. Dial. Transplant. (1998) [Pubmed]
  16. Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients. Poblete, B., Romand, J.A., Pichard, C., König, P., Suter, P.M. British journal of anaesthesia. (1997) [Pubmed]
  17. Comparison of cizolirtine citrate and metamizol sodium in the treatment of adult acute renal colic: a randomized, double-blind, clinical pilot study. Pavlik, I., Suchy, J., Pacík, D., Bokr, R., Sust, M., Villoria, J., Abadías, M. Clinical therapeutics. (2004) [Pubmed]
  18. Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Comparative analysis with acetylsalicylic acid and diclofenac. García-Martínez, J.M., Fresno Vara, J.A., Lastres, P., Bernabéu, C., Betés, P.O., Martín-Pérez, J. Biochem. Pharmacol. (2003) [Pubmed]
  19. Regulation of cyclooxygenase activity by metamizol. Campos, C., de Gregorio, R., García-Nieto, R., Gago, F., Ortiz, P., Alemany, S. Eur. J. Pharmacol. (1999) [Pubmed]
  20. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response. Gozzoli, V., Treggiari, M.M., Kleger, G.R., Roux-Lombard, P., Fathi, M., Pichard, C., Romand, J.A. Intensive care medicine. (2004) [Pubmed]
  21. Activation of inhibition from the periaqueductal grey matter mediates central analgesic effect of metamizol (dipyrone). Carlsson, K.H., Helmreich, J., Jurna, I. Pain (1986) [Pubmed]
  22. The flow-cytometric determination of basophil activation induced by aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is useful for in vitro diagnosis of the NSAID hypersensitivity syndrome. Gamboa, P., Sanz, M.L., Caballero, M.R., Urrutia, I., Antépara, I., Esparza, R., de Weck, A.L. Clin. Exp. Allergy (2004) [Pubmed]
  23. Opioid tolerance induced by metamizol (dipyrone) microinjections into the periaqueductal grey of rats. Tortorici, V., Vanegas, H. Eur. J. Neurosci. (2000) [Pubmed]
  24. Use of analgesics and nonsteroidal anti-inflammatory drugs, genetic predisposition, and bladder cancer risk in Spain. Fortuny, J., Kogevinas, M., Garcia-Closas, M., Real, F.X., Tardón, A., Garcia-Closas, R., Serra, C., Carrato, A., Lloreta, J., Rothman, N., Villanueva, C., Dosemeci, M., Malats, N., Silverman, D. Cancer Epidemiol. Biomarkers Prev. (2006) [Pubmed]
  25. Use of intravenous patient-controlled analgesia for the documentation of synergy between tramadol and metamizol. Montes, A., Warner, W., Puig, M.M. British journal of anaesthesia. (2000) [Pubmed]
  26. Immediate rhinoconjunctivitis induced by metamizole and metronidazole. Añíbarro, B., Fontela, J.L. Ann. Allergy Asthma Immunol. (1997) [Pubmed]
  27. Role of prostaglandins and nitric oxide in gastric damage induced by metamizol in rats. Sánchez, S., Martín, M.J., Ortiz, P., Motilva, V., Herrerías, J.M., Alarcón de la Lastra, C. Inflamm. Res. (2002) [Pubmed]
  28. The action of urocortins on body temperature in rats. Telegdy, G., Adamik, A., Tóth, G. Peptides (2006) [Pubmed]
  29. Use of CD63 expression as a marker of in vitro basophil activation and leukotriene determination in metamizol allergic patients. Gamboa, P.M., Sanz, M.L., Caballero, M.R., Antépara, I., Urrutia, I., Jáuregui, I., González, G., Diéguez, I., De Weck, A.L. Allergy (2003) [Pubmed]
  30. Effects of celecoxib on acid-challenged gastric mucosa of rats: comparison with metamizol and piroxicam. Berenguer, B., Alarcón De La Lastra, C., Motilva, V., La Casa, C., Herrerias, J.M., Pozo, D., Calero, M.J. Dig. Dis. Sci. (2004) [Pubmed]
  31. Pituitary adenylate cyclase-activating polypeptide induces hyperthermia in the rat. Pataki, I., Adamik, A., Jászberényi, M., Mácsai, M., Telegdy, G. Neuropharmacology (2000) [Pubmed]
  32. Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord. Taylor, J., Mellström, B., Fernaud, I., Naranjo, J.R. Eur. J. Pharmacol. (1998) [Pubmed]
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