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Chemical Compound Review

nicotinamide mononucleotide     [(2R,3S,4R,5R)-5-(5- aminocarbonylpyridin-1...

Synonyms: SureCN6858129, CHEBI:14648, AC1Q6RVF, AC1L23AN, NMN, ...
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Disease relevance of nicotinamide mononucleotide

  • Since NAD is the cofactor for polynucleotide ligase in Bacillus subtilis and NMN is known to discharge AMP from the active AMP ligase complex, it is proposed that activation of DNA ligase reduces dTMP incorporation by reducing sites for, or limiting DNA polymerase I action [1].

High impact information on nicotinamide mononucleotide

  • The use of NMN provides a direct means for evaluating the involvement of DNA polymerase I in excision repair [2].
  • A pnuB mutant, however, does not require the pnuA gene product for NMN uptake but does rely on the pnuC product [3].


  1. Depression by NAD of x-ray-induced repair-type DNA synthesis in toluene-treated Bacillus subtilis. Billen, D., Hellermann, G. Biochim. Biophys. Acta (1975) [Pubmed]
  2. DNA polymerase I-mediated ultraviolet repair synthesis in toluene-treated Escherichia coli. Dorson, J.W., Moses, R.E. J. Biol. Chem. (1978) [Pubmed]
  3. Genetic characterization of pyridine nucleotide uptake mutants of Salmonella typhimurium. Spector, M.P., Hill, J.M., Holley, E.A., Foster, J.W. J. Gen. Microbiol. (1985) [Pubmed]
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