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Gene Review

pnuC  -  nicotinamide riboside transporter PnuC

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

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Disease relevance of pnuC

  • Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium [1].

High impact information on pnuC

  • Polarity tests, with pnuC::Mu d-lac operon fusions, reveal that the pnuC gene is the promoter distal gene in an operon with the nadA gene, which encodes the second enzyme of the pyridine biosynthetic pathway [1].
  • The pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system, has been mapped and oriented [1].
  • The gene order of the pnuC region, which is at min 17 of the Salmonella chromosome, is nadA-pnuC-aroG-gal [1].
  • Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci [2].
  • A third class of uptake mutant, pnuC, isolated in a nadB pncA pnuB background, also failed to grow on NMN [3].

Associations of pnuC with chemical compounds

  • A pnuB mutant, however, does not require the pnuA gene product for NMN uptake but does rely on the pnuC product [3].


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