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Gene Review: 

pnuC  -  nicotinamide riboside transporter PnuC

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

 
 
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Disease relevance of pnuC

  • Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium [1].
 

High impact information on pnuC

  • Polarity tests, with pnuC::Mu d-lac operon fusions, reveal that the pnuC gene is the promoter distal gene in an operon with the nadA gene, which encodes the second enzyme of the pyridine biosynthetic pathway [1].
  • The pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system, has been mapped and oriented [1].
  • The gene order of the pnuC region, which is at min 17 of the Salmonella chromosome, is nadA-pnuC-aroG-gal [1].
  • Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci [2].
  • A third class of uptake mutant, pnuC, isolated in a nadB pncA pnuB background, also failed to grow on NMN [3].
 

Associations of pnuC with chemical compounds

  • A pnuB mutant, however, does not require the pnuA gene product for NMN uptake but does rely on the pnuC product [3].

References

  1. Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium. Zhu, N., Olivera, B.M., Roth, J.R. J. Bacteriol. (1989) [Pubmed]
  2. Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci. Tirgari, S., Spector, M.P., Foster, J.W. J. Bacteriol. (1986) [Pubmed]
  3. Genetic characterization of pyridine nucleotide uptake mutants of Salmonella typhimurium. Spector, M.P., Hill, J.M., Holley, E.A., Foster, J.W. J. Gen. Microbiol. (1985) [Pubmed]
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