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Chemical Compound Review:

Butylphenyl 1-butyl-2-phenyl-benzene

Synonyms: AG-F-89468, AC1L3MMU, CTK5A1492, 54532-97-7, EINECS 255-471-7, ...

Khan, N.N. et al., Blanco, L. et al., Imai, S. et al., Bender, M.A. et al.

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High impact information on Butylphenyl

BuPdGTP , the 2'-deoxyribonucleoside 5'-triphosphate of the DNA polymerase alpha (pol alpha)-specific inhibitor, N2-(p-n- butylphenyl )guanine, was examined with respect to its mechanism and its capacity to inhibit the mammalian DNA polymerases, pol alpha, pol beta, and pol gamma [1].
The drugs aphidicolin and the nucleotide analogs butylanilino dATP, butylphenyl dGTP, and butylphenyl rGTP inhibited the protein-primed replication of phi 29 DNA-protein p3 in the presence of purified terminal protein p3 and phi 29 DNA polymerase p2 [2].
The antispermatogenic effects of 2, 4-dinitro-6-tert-. butylphenyl methanesulfonate (HE-166) were studied in Sprague-Dawley rats [3].

Associations of Butylphenyl with other chemical compounds

The specific polymerase alpha inhibitor butylphenyl deoxyguanosine was used as an X-ray post-treatment [4].

References

Butylphenyl dGTP: a selective and potent inhibitor of mammalian DNA polymerase alpha. Khan, N.N., Wright, G.E., Dudycz, L.W., Brown, N.C. Nucleic Acids Res. (1984) [Pubmed]
Effect of aphidicolin and nucleotide analogs on the phage phi 29 DNA polymerase. Blanco, L., Salas, M. Virology (1986) [Pubmed]
The antispermatogenic effect and toxicity of 2, 4-dinitro-6-tert-butylphenyl methanesulfonate on Sprague-Dawley rat. Imai, S., Yamamoto, H., Tsubura, Y. The Journal of toxicological sciences. (1984) [Pubmed]
DNA polymerase alpha does not mediate G0-G1 increase in yield of X-ray-induced exchange aberrations in human peripheral blood lymphocytes. Bender, M.A., Moore, R.C. Mutat. Res. (1990) [Pubmed]

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