Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1L24CX (16R)-13-methyl- 6,7,8,9,11,12,14,15,16,17...

Synonyms:

Ohkubo, T. et al., Jin, C. et al., Ohkubo, T. et al., Fujii, Y. et al.

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High impact information on 2-HYDROXYESTRIOL

Like the previously reported enzyme, this variant efficiently glucuronidated hyodeoxycholic acid, estriol, 4-hydroxyestrone and 2-hydroxyestriol [1].
The conjugated positions of these compounds were definitely established by conversion to 2-hydroxyestriol monomethyl ethers by methylation, then enzymatic hydrolysis [2].

Analytical, diagnostic and therapeutic context of 2-HYDROXYESTRIOL

Development and application of a radioimmunoassay for 2-hydroxyestriol [3].
In vitro glucuronidation of 2-hydroxyestriol has been investigated by means of HPLC with dual-electrode coulometric detection [4].

References

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. Jin, C., Miners, J.O., Lillywhite, K.J., Mackenzie, P.I. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
Synthesis of 2-hydroxyestriol monoglucuronides and monosulfates. Ohkubo, T., Wakasawa, T., Nambara, T. Steroids (1990) [Pubmed]
Development and application of a radioimmunoassay for 2-hydroxyestriol. Fujii, Y., Teranishi, M., Mizukami, M., Ukari, H., Yamazaki, M., Horikawa, Y., Kishida, S., Miyabo, S. Chem. Pharm. Bull. (1986) [Pubmed]
Multiplicity of in vitro glucuronidation of 2-hydroxyestriol. Ohkubo, T., Takahashi, A., Nambara, T. J. Steroid Biochem. (1990) [Pubmed]

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