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Chemical Compound Review:

SureCN319529 1-aminocyclopropan-1-ol

Synonyms: AG-F-88477, AC1L3XLT, CTK1G8590, AKOS006339997, 54376-44-2, ...

Nilsson, G.E. et al., Marchner, H. et al., Marchner, H. et al., Hellström, E. et al.

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High impact information on Cyclopropanol, 1-amino-

The inhibition of the low-Km, rat-liver mitochondrial aldehyde dehydrogenase (ALDH) by the alcohol-sensitizing agents cyanamide, 1-aminocyclopropanol (ACP) and disulfiram was studied in vitro [1].
Aldehyde reductase was slightly inhibited by both disulfiram and 1-aminocyclopropanol in vitro [2].
Also the presence of diethyldithiocarbamate (160-1600 microM) was found to inhibit tryptophan hydroxylase (28-91%), while 5-hydroxyindole-3-acetaldehyde, coprine, or 1-aminocyclopropanol appeared to have no effect on the enzyme activity [3].
A comparative study on the effects of disulfiram, cyanamide and 1-aminocyclopropanol on the acetaldehyde metabolism in rats [4].

References

Studies in vitro on the inactivation of mitochondrial rat-liver aldehyde dehydrogenase by the alcohol-sensitizing compounds cyanamide, 1-aminocyclopropanol and disulfiram. Marchner, H., Tottmar, O. Biochem. Pharmacol. (1983) [Pubmed]
Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Hellström, E., Tottmar, O. Biochem. Pharmacol. (1982) [Pubmed]
Effects of biogenic aldehydes and aldehyde dehydrogenase inhibitors on rat brain tryptophan hydroxylase activity in vitro. Nilsson, G.E., Tottmar, O. Brain Res. (1987) [Pubmed]
A comparative study on the effects of disulfiram, cyanamide and 1-aminocyclopropanol on the acetaldehyde metabolism in rats. Marchner, H., Tottmar, O. Acta pharmacologica et toxicologica. (1978) [Pubmed]

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