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Chemical Compound Review

Antabuse     1- (diethylthiocarbamoyldisulfany l)-N,N...

Synonyms: Dicupral, Antabus, Anticol, Esperal, Refusal, ...
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Disease relevance of Anticol


Psychiatry related information on Anticol


High impact information on Anticol


Chemical compound and disease context of Anticol


Biological context of Anticol


Anatomical context of Anticol


Associations of Anticol with other chemical compounds


Gene context of Anticol

  • Nevertheless, the specificity of single-dose disulfiram toward human CYP2E1 in vivo is unknown [29].
  • In this study, we investigated the molecular and chemical basis of disulfiram as a multidrug resistance modulator [30].
  • Finally, we have exploited MRP4 (ABCC4) to demonstrate that disulfiram can inhibit ATP binding by forming disulfide bonds between cysteines located in the vicinity of, although not in, the active site [30].
  • METHODS: The involvement of CYP2E1 was assessed through pretreatment of adult human volunteers with disulfiram to inhibit the enzyme and the role of CYP3A4 through its induction in a second cohort of adults with rifampin (INN, rifampicin) [31].
  • Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation [32].

Analytical, diagnostic and therapeutic context of Anticol


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  2. Letter: Disulfiram hypersensitivity hepatitis. Fisher, A.A. JAMA (1975) [Pubmed]
  3. Does disulfiram cure psoriasis. Jewell, E.W. JAMA (1977) [Pubmed]
  4. Blockage of drug resistance in vitro by disulfiram, a drug used to treat alcoholism. Loo, T.W., Clarke, D.M. J. Natl. Cancer Inst. (2000) [Pubmed]
  5. Temazepam toxicity precipitated by disulfiram. Hardman, M., Biniwale, A., Clarke, C.E. Lancet (1994) [Pubmed]
  6. Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial. Carroll, K.M., Fenton, L.R., Ball, S.A., Nich, C., Frankforter, T.L., Shi, J., Rounsaville, B.J. Arch. Gen. Psychiatry (2004) [Pubmed]
  7. High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system. McCaffery, P., Dräger, U.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Disulfiram administration affects substance P-like immunoreactive and monoaminergic neural systems in rodent brain. Marchand, J.E., Hershman, K., Kumar, M.S., Thompson, M.L., Kream, R.M. J. Biol. Chem. (1990) [Pubmed]
  9. Imipramine treatment of alcoholism with comorbid depression. Nunes, E.V., McGrath, P.J., Quitkin, F.M., Stewart, J.P., Harrison, W., Tricamo, E., Ocepek-Welikson, K. The American journal of psychiatry. (1993) [Pubmed]
  10. Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder. Petrakis, I.L., Poling, J., Levinson, C., Nich, C., Carroll, K., Ralevski, E., Rounsaville, B. Biol. Psychiatry (2006) [Pubmed]
  11. Disulfiram hypersensitivity and rubber contact dermatitis. Webb, P.K., Gibbs, S.C., Mathias, C.T., Crain, W., Maibach, H. JAMA (1979) [Pubmed]
  12. Effects of disulfiram and pyridoxine on serum cholesterol. Major, L.F., Goyer, P.F. Ann. Intern. Med. (1978) [Pubmed]
  13. Carbamoylation of brain glutamate receptors by a disulfiram metabolite. Nagendra, S.N., Faiman, M.D., Davis, K., Wu, J.Y., Newby, X., Schloss, J.V. J. Biol. Chem. (1997) [Pubmed]
  14. Disulfiram and CS2 toxicity. Faiman, M.D., Haya, K., Ewing, J.A. The American journal of psychiatry. (1978) [Pubmed]
  15. Fulminant polyneuritis after overdose of disulfiram and ethanol. Rothrock, J.F., Johnson, P.C., Rothrock, S.M., Merkley, R. Neurology (1984) [Pubmed]
  16. Genetic differences in alcohol drinking preference between inbred strains of mice. He, X.X., Nebert, D.W., Vasiliou, V., Zhu, H., Shertzer, H.G. Pharmacogenetics (1997) [Pubmed]
  17. Liver alcohol dehydrogenase and aldehyde dehydrogenase in the Japanese: isozyme variation and its possible role in alcohol intoxication. Harada, S., Misawa, S., Agarwal, D.P., Goedde, H.W. Am. J. Hum. Genet. (1980) [Pubmed]
  18. Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum. Scheibel, L.W., Adler, A., Trager, W. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  19. Retinoic acid regulates postnatal neurogenesis in the murine subventricular zone-olfactory bulb pathway. Wang, T.W., Zhang, H., Parent, J.M. Development (2005) [Pubmed]
  20. 1,2-Dimethylhydrazine-induced methylation of DNA bases in various rat organs and the effect of pretreatment with disulfiram. Swenberg, J.A., Cooper, H.K., Bücheler, J., Kleihues, P. Cancer Res. (1979) [Pubmed]
  21. Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents. Wozniak, A.J., Glisson, B.S., Hande, K.R., Ross, W.E. Cancer Res. (1984) [Pubmed]
  22. Induction of DT-diaphorase by anticarcinogenic sulfur compounds in mice. Benson, A.M., Barretto, P.B., Stanley, J.S. J. Natl. Cancer Inst. (1986) [Pubmed]
  23. Disulfiram-induced myocardial and skeletal-muscle degeneration in rats. Ekvärn, S., Jönsson, M., Lindquist, N.G., Holmberg, B., Kronevi, T. Lancet (1977) [Pubmed]
  24. Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. Ying, T.S., Sarma, D.S., Farber, E. Cancer Res. (1981) [Pubmed]
  25. Role of microtubuli in secretion of very-low-density lipoprotein in isolated rat hepatocytes: early effects of thiol reagents. Nagelkerke, J.F., van de Water, B., Twiss, I.M., Zoetewey, J.P., de Bont, H.J., Dogterom, P., Mulder, G.J. Hepatology (1991) [Pubmed]
  26. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. Keung, W.M., Klyosov, A.A., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  27. Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism. Keung, W.M., Lazo, O., Kunze, L., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  28. Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain. Ryu, Y.H., Liow, J.S., Zoghbi, S., Fujita, M., Collins, J., Tipre, D., Sangare, J., Hong, J., Pike, V.W., Innis, R.B. J. Nucl. Med. (2007) [Pubmed]
  29. Single-dose disulfiram does not inhibit CYP2A6 activity. Kharasch, E.D., Hankins, D.C., Baxter, P.J., Thummel, K.E. Clin. Pharmacol. Ther. (1998) [Pubmed]
  30. The molecular basis of the action of disulfiram as a modulator of the multidrug resistance-linked ATP binding cassette transporters MDR1 (ABCB1) and MRP1 (ABCC1). Sauna, Z.E., Peng, X.H., Nandigama, K., Tekle, S., Ambudkar, S.V. Mol. Pharmacol. (2004) [Pubmed]
  31. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Manyike, P.T., Kharasch, E.D., Kalhorn, T.F., Slattery, J.T. Clin. Pharmacol. Ther. (2000) [Pubmed]
  32. Identification of the human P-450 enzymes responsible for the sulfoxidation and thiono-oxidation of diethyldithiocarbamate methyl ester: role of P-450 enzymes in disulfiram bioactivation. Madan, A., Parkinson, A., Faiman, M.D. Alcohol. Clin. Exp. Res. (1998) [Pubmed]
  33. Disulfiram treatment of alcoholism. A Veterans Administration cooperative study. Fuller, R.K., Branchey, L., Brightwell, D.R., Derman, R.M., Emrick, C.D., Iber, F.L., James, K.E., Lacoursiere, R.B., Lee, K.K., Lowenstam, I. JAMA (1986) [Pubmed]
  34. The medical safety of the combined usage of disulfiram and methadone. Pharmacological treatment for alcoholic heroin addicts. Charuvastra, C.V., Panell, J., Hopper, M., Erhmann, M., Blakis, M., Ling, W. Arch. Gen. Psychiatry (1976) [Pubmed]
  35. Increased pressure for rapid eye movement sleep at time of hospital admission predicts relapse in nondepressed patients with primary alcoholism at 3-month follow-up. Gillin, J.C., Smith, T.L., Irwin, M., Butters, N., Demodena, A., Schuckit, M. Arch. Gen. Psychiatry (1994) [Pubmed]
  36. Cu/Zn superoxide dismutase plays important role in immune response. Marikovsky, M., Ziv, V., Nevo, N., Harris-Cerruti, C., Mahler, O. J. Immunol. (2003) [Pubmed]
  37. Elimination characteristics of disulfiram over time in five alcoholic volunteers: a preliminary study. Jensen, J.C., Faiman, M.D., Hurwitz, A. The American journal of psychiatry. (1982) [Pubmed]
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