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Gene Review

Tph1  -  tryptophan hydroxylase 1

Rattus norvegicus

Synonyms: Tph, Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1
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Disease relevance of Tph1


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Chemical compound and disease context of Tph1


Biological context of Tph1


Anatomical context of Tph1


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Physical interactions of Tph1


Regulatory relationships of Tph1


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Analytical, diagnostic and therapeutic context of Tph1


  1. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Liang, J., Wessel, J.H., Iuvone, P.M., Tosini, G., Fukuhara, C. Neuroreport (2004) [Pubmed]
  2. Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line. Iida, Y., Sawabe, K., Kojima, M., Oguro, K., Nakanishi, N., Hasegawa, H. Eur. J. Biochem. (2002) [Pubmed]
  3. "7-tetrahydrobiopterin," a naturally occurring analogue of tetrahydrobiopterin, is a cofactor for and a potential inhibitor of the aromatic amino acid hydroxylases. Davis, M.D., Ribeiro, P., Tipper, J., Kaufman, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. Ontogenesis of monoamine-synthesizing enzyme activities and biopterin levels in rat brain or salivary glands, and the effects of thyroxine administration. Kato, T., Yamaguchi, T., Togari, A., Nagatsu, T., Yajima, T., Maeda, N., Kumegawa, M. J. Neurochem. (1982) [Pubmed]
  5. Stereotaxic injection of tetanus toxin in rat central nervous system causes alteration in normal levels of monoamines. Aguilera, J., López, L.A., González-Sastre, F. J. Neurochem. (1991) [Pubmed]
  6. (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Nicholson, A.N., Wright, C.M. Neuropharmacology (1981) [Pubmed]
  7. Amphetamine and alpha-methyl-p-tyrosine affect the exercise-induced imbalance between the availability of tryptophan and synthesis of serotonin in the brain of the rat. Chaouloff, F., Laude, D., Merino, D., Serrurrier, B., Guezennec, Y., Elghozi, J.L. Neuropharmacology (1987) [Pubmed]
  8. Hypothalamic tryptophan hydroxylase and the hypothalamic-pituitary-adrenocortical response to water deprivation and hydration in vasopressin-deficient and normal rats. Popova, N.K., Naumenko, K.S., Maslova, L.N., Amstislavskaya, T.G., Melidi, N.N., Bulygina, V.V., Ivanova, L.N. Pflugers Arch. (2002) [Pubmed]
  9. Reductions in pain thresholds and morphine analgesia following intracerebroventricular parachlorophenylalanine. Bodnar, R.J., Kordower, J.H., Reches, A., Wallace, M.M., Fahn, S. Pharmacol. Biochem. Behav. (1984) [Pubmed]
  10. Increased brain serotonin metabolism during rebound sleep in sleep-deprived rats. Toru, M., Mitsushio, H., Mataga, N., Takashima, M., Arito, H. Pharmacol. Biochem. Behav. (1984) [Pubmed]
  11. P-Chloramphetamine: Selective neurotoxic action in brain. Harvey, J.A., McMaster, S.E., Yunger, L.M. Science (1975) [Pubmed]
  12. Long-term regulation of serotonergic activity in the rat brain via activation of protein kinase A. Foguet, M., Hartikka, J.A., Schmuck, K., Lübbert, H. EMBO J. (1993) [Pubmed]
  13. Full-length cDNA for rabbit tryptophan hydroxylase: functional domains and evolution of aromatic amino acid hydroxylases. Grenett, H.E., Ledley, F.D., Reed, L.L., Woo, S.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  14. Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin. Kuhn, D.M., O'Callaghan, J.P., Juskevich, J., Lovenberg, W. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  15. Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain. Rastogi, R.B., Singhal, R.L. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  16. Effect of neonatal hypothyroidism on the serotonin system of the rat brain. Savard, P., Mérand, Y., Di Paolo, T., Dupont, A. Brain Res. (1984) [Pubmed]
  17. Effect of methamphetamine on tryptophan hydroxylase activity: role of hyperthermia. Fleckenstein, A.E. Eur. J. Pharmacol. (1997) [Pubmed]
  18. Activity of tryptophan hydroxylase and content of indolamines in discrete brain regions after a long-term hypoxic exposure in the rat. Poncet, L., Denoroy, L., Dalmaz, Y., Pequignot, J.M. Brain Res. (1997) [Pubmed]
  19. Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity. Che, S., Johnson, M., Hanson, G.R., Gibb, J.W. Eur. J. Pharmacol. (1995) [Pubmed]
  20. Immobilization stress elevates tryptophan hydroxylase mRNA and protein in the rat raphe nuclei. Chamas, F.M., Underwood, M.D., Arango, V., Serova, L., Kassir, S.A., Mann, J.J., Sabban, E.L. Biol. Psychiatry (2004) [Pubmed]
  21. Involvement of NF-Y and Sp1 in basal and cAMP-stimulated transcriptional activation of the tryptophan hydroxylase (TPH ) gene in the pineal gland. Côté, F., Schussler, N., Boularand, S., Peirotes, A., Thévenot, E., Mallet, J., Vodjdani, G. J. Neurochem. (2002) [Pubmed]
  22. Estrogen selectively increases tryptophan hydroxylase-2 mRNA expression in distinct subregions of rat midbrain raphe nucleus: association between gene expression and anxiety behavior in the open field. Hiroi, R., McDevitt, R.A., Neumaier, J.F. Biol. Psychiatry (2006) [Pubmed]
  23. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Patel, P.D., Pontrello, C., Burke, S. Biol. Psychiatry (2004) [Pubmed]
  24. Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain. Joh, T.H., Shikimi, T., Pickel, V.M., Reis, D.J. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  25. Maternal ethanol administration inhibits 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe of rat offspring. Kim, E.K., Lee, M.H., Kim, H., Sim, Y.J., Shin, M.S., Lee, S.J., Yang, H.Y., Chang, H.K., Lee, T.H., Jang, M.H., Shin, M.C., Lee, H.H., Kim, C.J. Brain Dev. (2005) [Pubmed]
  26. Male Fischer 344 and Lewis rats display differences in locomotor reactivity, but not in anxiety-related behaviours: relationship with the hippocampal serotonergic system. Chaouloff, F., Kulikov, A., Sarrieau, A., Castanon, N., Mormède, P. Brain Res. (1995) [Pubmed]
  27. Tryptophan hydroxylase: purification by affinity chromatography on calmodulin-sepharose. D'Sa, C., Arthur, R., Jennings, I., Cotton, R.G., Kuhn, D.M. J. Neurosci. Methods (1996) [Pubmed]
  28. Effect of reactive oxygen species on the metabolism of tryptophan in rat brain: influence of age. Hussain, A.M., Mitra, A.K. Mol. Cell. Biochem. (2004) [Pubmed]
  29. Changes in steady-state levels of tryptophan hydroxylase protein in adult rat brain after neonatal 6-hydroxydopamine lesion. Raison, S., Weissmann, D., Rousset, C., Pujol, J.F., Descarries, L. Neuroscience (1995) [Pubmed]
  30. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. Liu, R.J., Lambe, E.K., Aghajanian, G.K. Eur. J. Neurosci. (2005) [Pubmed]
  31. Effect of the destruction of cells containing the serotonin reuptake transporter on urethrogenital reflexes. Gravitt, K., Marson, L. The journal of sexual medicine (2007) [Pubmed]
  32. Regulation of the transmitter phenotype of rostral and caudal groups of cultured serotonergic raphe neurons. Galter, D., Unsicker, K. Neuroscience (1999) [Pubmed]
  33. Developmental regulation of early serotonergic neuronal differentiation: the role of brain-derived neurotrophic factor and membrane depolarization. Eaton, M.J., Staley, J.K., Globus, M.Y., Whittemore, S.R. Dev. Biol. (1995) [Pubmed]
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