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Chemical Compound Review:

Coprine (2S)-2-amino-4-[(1- hydroxycyclopropyl)carb...

Synonyms: L-coprine, SureCN320268, CHEBI:3875, AC1Q5LHE, AR-1J7156, ...

Tottmar, O. et al., Nilsson, G.E. et al., Nilsson, G.E. et al., Nilsson, G.E. et al., Jönsson, M. et al., et al.

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Disease relevance of C08271

However, this effect was accompanied by tachycardia only in animals treated with coprine [1].

High impact information on C08271

The brain ALDH-activity with a high acetaldehyde concentration was significantly decreased by coprine and cyanamide but not by disulfiram [2].
The effect of indole-3-acetaldehyde, 5-hydroxyindole-3-acetaldehyde, disulfiram, diethyldithiocarbamate, coprine, and 1-amino-cyclopropanol on tryptophan hydroxylase activity was studied in vitro using high performance liquid chromatography with electro-chemical detection [3].
Regarding the 5-hydroxyindole-3-acetic acid concentration, this appeared to be increased by disulfiram in both age-groups, while no significant effects were found with coprine [4].
In conclusion benzcoprine and coprine were found to cause severe changes in the testis in rats and dogs, probably due to a direct effect on the germ cells [5].
Disulfiram and FLA-57, but not cyanamide and coprine, decreased the DBH-activity in the heart and the levels of norepinephrine in the heart and the brain [6].

Biological context of C08271

In rats pretreated with coprine + FLA-57, the fall in blood pressure was similar, or even lower, than in rats pretreated with coprine alone [6].

Associations of C08271 with other chemical compounds

In the present study, disulfiram (300 mg/kg) was found to cause a 4-fold prolongation of hexobarbital-induced anaesthesia, while coprine (another potent ALDH-inhibitor) had no effect [7].

Gene context of C08271

In disulfiram-treated rats with a DBH-activity close to control activity and in rats pretreated with cyanamide or coprine, a fall in blood pressure were observed in rats pretreated with FLA-57 [6].

References

On the disulfiram-like effect of coprine, the pharmacologically active principle of Coprinus atramentarius. Carlsson, A., Henning, M., Lindberg, P., Martinson, P., Trolin, G., Waldeck, B., Wickberg, B. Acta pharmacologica et toxicologica. (1978) [Pubmed]
Effects of aldehyde dehydrogenase inhibitors on enzymes involved in the metabolism of biogenic aldehydes in rat liver and brain. Hellström, E., Tottmar, O. Biochem. Pharmacol. (1982) [Pubmed]
Effects of biogenic aldehydes and aldehyde dehydrogenase inhibitors on rat brain tryptophan hydroxylase activity in vitro. Nilsson, G.E., Tottmar, O. Brain Res. (1987) [Pubmed]
Effects of disulfiram and coprine on rat brain tryptophan hydroxylation in vivo. Nilsson, G.E., Tottmar, O. Neurochem. Res. (1989) [Pubmed]
Testicular lesions of coprine and benzcoprine. Jönsson, M., Lindquist, N.G., Plöen, L., Ekvärn, S., Kronevi, T. Toxicology (1979) [Pubmed]
Blood pressure response to ethanol in relation to acetaldehyde levels and dopamine-beta-hydroxylase activity in rats pretreated with disulfiram, cyanamide and coprine. Tottmar, O., Hellström, E. Acta pharmacologica et toxicologica. (1979) [Pubmed]
Effects of aldehyde dehydrogenase inhibitors on hexobarbital sensitivity and neuroamine metabolism in rat brain. Nilsson, G.E., Tottmar, O., Wahlström, G. Brain Res. (1987) [Pubmed]

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