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Chemical Compound Review:

AC1L4420 2-acetyloxybenzoic acid; 2...

Synonyms: 53908-21-7, Excedrin Migraine, EXCEDRIN (MIGRAINE), ACETAMINOPHEN, ASPIRIN AND CAFFEINE

Diamond, M.L. et al., Evans, R.W., Strong, F.C.

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Disease relevance of Excedrin

Warning: the excedrin migraine warning label is inadequate to warn consumers of the risk of medication rebound headache [1].

High impact information on Excedrin

METHODS: One hundred ten patients meeting criteria for migraine who were poor responders to Excedrin received open-label treatment with a 40-mg dose of eletriptan for one migraine attack [2].

Chemical compound and disease context of Excedrin

OBJECTIVE: To evaluate the effectiveness of eletriptan as a treatment for acute migraine in patients who were poor responders to Excedrin and had not yet been exposed to a triptan [2].
It may be the caffeine in Extra Strength Excedrin that is effective for migraine [3].

Analytical, diagnostic and therapeutic context of Excedrin

BACKGROUND: Self-medication with over-the-counter drugs, such as Excedrin, is the most common treatment for migraine [2].

References

Warning: the excedrin migraine warning label is inadequate to warn consumers of the risk of medication rebound headache. Evans, R.W. Headache. (1999) [Pubmed]
Effectiveness of eletriptan in acute migraine: primary care for Excedrin nonresponders. Diamond, M.L., Hettiarachchi, J., Hilliard, B., Sands, G., Nett, R. Headache. (2004) [Pubmed]
It may be the caffeine in Extra Strength Excedrin that is effective for migraine. Strong, F.C. J. Pharm. Pharmacol. (1997) [Pubmed]

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