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Chemical Compound Review

AC1L450F     (8S,9S,10S,13R,14S,17S)-17- ethyl-2,3,3...

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Disease relevance of Pregnanetriolone


High impact information on Pregnanetriolone

  • Patients 1 and 2 (first cousins, raised as males) had inter-sexual external genitalia, some spontaneous male pubertal development, some response of plasma testosterone to hCG, low plasma dehydroepiandrosterone, and pregnanetriolone (3 alpha, 17 alpha, 20 alpha-trihydroxypregnan-11-one) in urine [3].
  • These results are compatible with and support the conclusion that the ovary of POS patients who excrete pregnanetriolone contains an 11beta-hydroxylase capable of hydroxylating C-21-deoxysteroids but not C-21-hydroxysteroids [4].

Chemical compound and disease context of Pregnanetriolone


Biological context of Pregnanetriolone


  1. A test for heterozygocity of 21-hydroxylase deficiency: preliminary report. Homoki, J., Teller, W.M., Fazekas, A.T. Hum. Genet. (1976) [Pubmed]
  2. Pregnanetriolone, a normal steroid metabolite: its excretion by normal, Cushing's syndrome and congenital adrenal hyperplasia subjects. Lahoud, H.J., Luttrell, B.M., Steinbeck, A.W. Steroids (1976) [Pubmed]
  3. Two types of male pseudohermaphroditism due to 17, 20-desmolase deficiency. Zachmann, M., Werder, E.A., Prader, A. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  4. 11 beta-Hydroxylase with affinity to C-21-Deoxysteroids from ovaries of patients with polycystic ovary syndrome. Maschler, I., Salzberger, M., Finkelstein, M. J. Clin. Endocrinol. Metab. (1975) [Pubmed]
  5. Apparent double defect in C11 beta and C21-steroid hydroxylation in congenital adrenal hyperplasia. Finkelstein, M., Litvin, Y., Mizrachi, Y., Neiman, G., Rösler, A. J. Steroid Biochem. (1983) [Pubmed]
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