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Chemical Compound Review

CORTODOXONE     (8R,9S,10R,13S,14S,17R)-17- hydroxy-17-(2...

Synonyms: Cortexolone, Cortodoxona, Cortoxelone, 11-Deoxycortisol, 11 Deoxycortisol, ...
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Disease relevance of Cortexolone


Psychiatry related information on Cortexolone


High impact information on Cortexolone


Chemical compound and disease context of Cortexolone


Biological context of Cortexolone


Anatomical context of Cortexolone


Associations of Cortexolone with other chemical compounds


Gene context of Cortexolone

  • The substrate for CYP11B2 is 11-deoxycorticosterone, that of CYP11B1 is 11-deoxycortisol [28].
  • However, the responses of DOC (P = 0.002 and P = 0.001, respectively) and 11-deoxycortisol (P = 0.025 and P = 0.002, respectively) were significantly greater in subjects homozygous for SF-1 T and/or intron conversion than in those homozygous for SF-1 C and/or normal intron [29].
  • Thereafter ACTH and AVP were sampled at 10-min intervals, CRF at 20-min intervals, and cortisol and 11-deoxycortisol at hourly intervals until 12:00 h on day 2 [30].
  • The decline in delta sleep was significantly associated with the magnitude of increase in both 11-deoxycortisol and ACTH [31].
  • In our previous studies we had demonstrated that, in children affected with isolated GH deficiency (IGHD), a short-term recombinant growth hormone (rGH) therapy increases the 11-deoxycortisol (S) secretion and induces an IGF-I responsiveness to the ACTH challenge [32].

Analytical, diagnostic and therapeutic context of Cortexolone


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  2. Adrenal androgen excess and defective 11 beta-hydroxylation in women with idiopathic hirsutism. Guthrie, G.P., Wilson, E.A., Quillen, D.L., Jawad, M.J. Arch. Intern. Med. (1982) [Pubmed]
  3. Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency. Tonetto-Fernandes, V., Lemos-Marini, S.H., Kuperman, H., Ribeiro-Neto, L.M., Verreschi, I.T., Kater, C.E. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  4. Steroidogenesis in an estrogen-producing adrenal tumor in a young woman: comparison with steroid profiles associated with cortisol- and androgen-producing tumors. McKenna, T.J., O'Connell, Y., Cunningham, S., McCabe, M., Culliton, M. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  5. Oxidative side-chain and ring fission of pregnanes by Arthrobacter simplex. Mahato, S.B., Banerjee, S., Podder, S. Biochem. J. (1988) [Pubmed]
  6. Glucocorticoid feedback sensitivity and adrenocortical responsiveness in posttraumatic stress disorder. Kanter, E.D., Wilkinson, C.W., Radant, A.D., Petrie, E.C., Dobie, D.J., McFall, M.E., Peskind, E.R., Raskind, M.A. Biol. Psychiatry (2001) [Pubmed]
  7. Plasma cortisol and 11-deoxycortisol activity in depressed patients and normal volunteers. Schweitzer, I., Tuckwell, V.M., Maguire, K.P., Tiller, J.W., Harrison, L.C., Davies, B.M. Psychoneuroendocrinology (1991) [Pubmed]
  8. The metyrapone and dexamethasone suppression tests for the differential diagnosis of the adrenocorticotropin-dependent Cushing syndrome: a comparison. Avgerinos, P.C., Yanovski, J.A., Oldfield, E.H., Nieman, L.K., Cutler, G.B. Ann. Intern. Med. (1994) [Pubmed]
  9. Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency. Pascoe, L., Curnow, K.M., Slutsker, L., Rösler, A., White, P.C. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  10. The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. Curnow, K.M., Tusie-Luna, M.T., Pascoe, L., Natarajan, R., Gu, J.L., Nadler, J.L., White, P.C. Mol. Endocrinol. (1991) [Pubmed]
  11. Mineralocorticoid receptor function in posttraumatic stress disorder after pretreatment with metyrapone. Otte, C., Muhtz, C., Daneshkhah, S., Yassouridis, A., Kiefer, F., Wiedemann, K., Kellner, M. Biol. Psychiatry (2006) [Pubmed]
  12. Four Novel Missense Mutations in the CYP21A2 Gene Detected in Russian Patients Suffering from the Classical Form of Congenital Adrenal Hyperplasia: Identification, Functional Characterization, and Structural Analysis. Grischuk, Y., Rubtsov, P., Riepe, F.G., Gr??tzinger, J., Beljelarskaia, S., Prassolov, V., Kalintchenko, N., Semitcheva, T., Peterkova, V., Tiulpakov, A., Sippell, W.G., Krone, N. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  13. Steroid content of the peripheral and adrenal vein in Cushing's syndrome due to adrenocortical adenoma and carcinoma. Levine, A.C., Mitty, H.A., Gabrilove, J.L. J. Urol. (1988) [Pubmed]
  14. Use of steroid profiles in determining the cause of adrenal insufficiency. Holst, J.P., Soldin, S.J., Tractenberg, R.E., Guo, T., Kundra, P., Verbalis, J.G., Jonklaas, J. Steroids (2007) [Pubmed]
  15. Electron microscopic findings in benign deoxycorticosterone and 11-deoxycortisol-producing adrenal tumor. Osanai, T., Konta, A., Chui, D., Kanazawa, T., Onodera, K., Kogawa, T. Arch. Pathol. Lab. Med. (1990) [Pubmed]
  16. Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome. Dall'Asta, C., Barbetta, L., Libé, R., Passini, E., Ambrosi, B. Horm. Res. (2002) [Pubmed]
  17. 11 Beta-hydroxylase deficiency congenital adrenal hyperplasia: update of prenatal diagnosis. Rösler, A., Weshler, N., Leiberman, E., Hochberg, Z., Weidenfeld, J., Sack, J., Chemke, J. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  18. Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion. Keavney, B., Mayosi, B., Gaukrodger, N., Imrie, H., Baker, M., Fraser, R., Ingram, M., Watkins, H., Farrall, M., Davies, E., Connell, J. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  19. Visualizing the vitreous body in the anterior chamber using 11-deoxycortisol after posterior capsule rupture in an animal model. Kaji, Y., Hiraoka, T., Okamoto, F., Sato, M., Hu, B., Yamane, N., Oshika, T. Ophthalmology (2004) [Pubmed]
  20. A direct radioimmunoassay for 11-deoxycortisol. Perry, L.A., Al-Dujaili, E.A., Edwards, C.R. Steroids (1982) [Pubmed]
  21. Identification and quantification of steroids in the serum of rainbow trout during spermiation and oocyte maturation. Campbell, C.M., Fostier, A., Jalabert, B., Truscott, B. J. Endocrinol. (1980) [Pubmed]
  22. Activity of melatonin and other pineal indoles on the in vitro synthesis of cortisol, cortisone, and adrenal androgens. Touitou, Y., Bogdan, A., Auzéby, A., Touitou, C. J. Pineal Res. (1989) [Pubmed]
  23. Factors involved in supporting the growth and steroidogenic functions of bovine adrenal cortical cells maintained on extracellular matrix and exposed to a serum-free medium. Ill, C.R., Gospodarowicz, D. J. Cell. Physiol. (1982) [Pubmed]
  24. The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism. Villuendas, G., San Millán, J.L., Sancho, J., Escobar-Morreale, H.F. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  25. Specificity of low dose fadrozole hydrochloride (CGS 16949A) as an aromatase inhibitor. Santen, R.J., Demers, L.M., Lynch, J., Harvey, H., Lipton, A., Mulagha, M., Hanagan, J., Garber, J.E., Henderson, I.C., Navari, R.M. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  26. Adrenal abnormalities in polycystic ovary syndrome. Loughlin, T., Cunningham, S., Moore, A., Culliton, M., Smyth, P.P., McKenna, T.J. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  27. Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. den Brinker, M., Joosten, K.F., Liem, O., de Jong, F.H., Hop, W.C., Hazelzet, J.A., van Dijk, M., Hokken-Koelega, A.C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  28. Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies. Peter, M., Dubuis, J.M., Sippell, W.G. Horm. Res. (1999) [Pubmed]
  29. An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects. Davies, E., Holloway, C.D., Ingram, M.C., Friel, E.C., Inglis, G.C., Swan, L., Hillis, W.S., Fraser, R., Connell, J.M. Clin. Endocrinol. (Oxf) (2001) [Pubmed]
  30. Metyrapone induced increase in plasma corticotropin is not associated with changes in peripheral venous arginine vasopressin or corticotropin releasing factor. Holmes, S.J., Florkowski, C.M., Evans, M.J., Ellis, M.J., Livesey, J.H., Donald, R.A., Espiner, E.A. J. Endocrinol. Invest. (1993) [Pubmed]
  31. Delta sleep response to metyrapone in post-traumatic stress disorder. Neylan, T.C., Lenoci, M., Maglione, M.L., Rosenlicht, N.Z., Metzler, T.J., Otte, C., Schoenfeld, F.B., Yehuda, R., Marmar, C.R. Neuropsychopharmacology (2003) [Pubmed]
  32. Further evaluation of IGF-I responsiveness to ACTH in children affected with IGHD. Merola, B., Rossi, E., Longobardi, S., Selleri, A., Esposito, V., Colao, A., Cataldi, M., Ferone, D., Lombardi, G. Horm. Res. (1992) [Pubmed]
  33. Plasma aldosterone and 11-deoxycortisol in term neonates: a reevaluation. Dörr, H.G., Sippell, W.G., Versmold, H.T., Bidlingmaier, F., Knorr, D. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  34. Nonchromatographic radioimmunoassay of plasma 11-deoxycortisol, for use in the metyrapone test, with polyethylene glycol as the precipant. Lee, L.M., Schiller, H.S. Clin. Chem. (1975) [Pubmed]
  35. Polarization fluoroimmunoassay of 11-deoxycortisol in serum and saliva. Al-Ansari, A.A., Massoud, M., Perry, L.A., Smith, D.S. Clin. Chem. (1983) [Pubmed]
  36. Determination of serum cortisol and 11-deoxycortisol by liquid chromatography. Reardon, G.E., Caldarella, A.M., Canalis, E. Clin. Chem. (1979) [Pubmed]
  37. Levels of adrenal and gonadal hormones in rhesus monkeys during chronic hypokinesia. Goncharov, N.P., Tavadyan, D.S., Powell, J.E., Stevens, V.C. Endocrinology (1984) [Pubmed]
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