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Chemical Compound Review

CORTODOXONE     (8R,9S,10R,13S,14S,17R)-17- hydroxy-17-(2...

Synonyms: Cortexolone, Cortodoxona, Cortoxelone, 11-Deoxycortisol, 11 Deoxycortisol, ...
 
 
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Disease relevance of Cortexolone

 

Psychiatry related information on Cortexolone

 

High impact information on Cortexolone

 

Chemical compound and disease context of Cortexolone

 

Biological context of Cortexolone

 

Anatomical context of Cortexolone

 

Associations of Cortexolone with other chemical compounds

 

Gene context of Cortexolone

  • The substrate for CYP11B2 is 11-deoxycorticosterone, that of CYP11B1 is 11-deoxycortisol [28].
  • However, the responses of DOC (P = 0.002 and P = 0.001, respectively) and 11-deoxycortisol (P = 0.025 and P = 0.002, respectively) were significantly greater in subjects homozygous for SF-1 T and/or intron conversion than in those homozygous for SF-1 C and/or normal intron [29].
  • Thereafter ACTH and AVP were sampled at 10-min intervals, CRF at 20-min intervals, and cortisol and 11-deoxycortisol at hourly intervals until 12:00 h on day 2 [30].
  • The decline in delta sleep was significantly associated with the magnitude of increase in both 11-deoxycortisol and ACTH [31].
  • In our previous studies we had demonstrated that, in children affected with isolated GH deficiency (IGHD), a short-term recombinant growth hormone (rGH) therapy increases the 11-deoxycortisol (S) secretion and induces an IGF-I responsiveness to the ACTH challenge [32].
 

Analytical, diagnostic and therapeutic context of Cortexolone

References

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