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Chemical Compound Review:

SureCN751609 (2S)-2-amino-3-(2-fluoro-4- hydroxy...

Synonyms: AG-H-15734, CTK2H6132, AKOS006237660, FT-0612439, AC1L46EI, ...

Brooks, B. et al., Faleev, N.G. et al., Faleev, N.G. et al., Phillips, R.S. et al.

Faleev, Axenova, Demidkina, Phillips,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 2-Fluorotyrosine

Versions of the Y55F/Y88F modified form of Delta 5-3-ketosteroid isomerase in which the active-site tyrosine-14 is replaced by 2-fluorotyrosine, 3-fluorotyrosine, and 2,3-difluorotyrosine, amino acids having progressively greater acidity of their phenolic hydroxyls, have been expressed in an Escherichia coli host and purified to high homogeneity [1].
The pH-dependencies of the main kinetic parameters for the reactions of Erwinia TPL with tyrosine, 2-fluorotyrosine, 3-fluorotyrosine, 2-chlorotyrosine, and 3,4-dihydroxyphenylalanine (DOPA) have been studied [2].

High impact information on 2-Fluorotyrosine

Oxygenation of 2-fluorotyrosine is regioselective, and only 6-fluorodopa was detected by HPLC in reaction mixtures [3].
In the present work, we examined pH dependencies for 2-fluorotyrosine, 3-fluorotyrosine, 3,5-difluorotyrosine, 2,5-difluorotyrosine, 2,6-difluorotyrosine, and 3-chlorotyrosine which are more acidic than tyrosine [4].

References

High-efficiency incorporation in vivo of tyrosine analogues with altered hydroxyl acidity in place of the catalytic tyrosine-14 of Delta 5-3-ketosteroid isomerase of Comamonas (Pseudomonas) testosteroni: effects of the modifications on isomerase kinetics. Brooks, B., Phillips, R.S., Benisek, W.F. Biochemistry (1998) [Pubmed]
The catalytic mechanism of tyrosine phenol-lyase from Erwinia herbicola: the effect of substrate structure on pH-dependence of kinetic parameters in the reactions with ring-substituted tyrosines. Faleev, N.G., Spirina, S.N., Ivoilov, V.S., Demidkina, T.V., Phillips, R.S. Z. Naturforsch., C, J. Biosci. (1996) [Pubmed]
Oxygenation of fluorinated tyrosines by mushroom tyrosinase releases fluoride ion. Phillips, R.S., Fletcher, J.G., Von Tersch, R.L., Kirk, K.L. Arch. Biochem. Biophys. (1990) [Pubmed]
The role of acidic dissociation of substrate's phenol group in the mechanism of tyrosine phenol-lyase. Faleev, N.G., Axenova, O.V., Demidkina, T.V., Phillips, R.S. Biochim. Biophys. Acta (2003) [Pubmed]

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