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Chemical Compound Review:

SureCN6046185 2-amino-3-(2-fluoro-3,4- dihydroxy...

Synonyms: NSC-383033, AC1L7YJZ, NSC383033, AC1Q5S4D, 2-Fluorodopa, ...

Meyer-Lindenberg, A. et al., Wu, R.M. et al., Petruk, K.C. et al., Calne, D.B. et al., Rosenberg, N.L. et al.

Meyer-Lindenberg, Miletich, Kohn, Esposito, Carson, Quarantelli, Weinberger, Berman,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NSC383033

Cyanide-induced parkinsonism: clinical, MRI, and 6-fluorodopa PET studies [1].
We report on clinical (18)F-labeled 6-fluorodopa ((18)F-dopa) positron emission tomography (PET) and molecular genetic analyses of an ethnic Chinese family in which three siblings presented with early-onset Parkinson's disease [2].

High impact information on NSC383033

The dopa analogue 6-fluorodopa (6-FD) used with positron emission tomography (PET) allows in vivo visualization of dopamine and its metabolites in nigrostriatal nerve endings [3].
The tight within-patient coupling of these values, with decreased PFC activation predicting exaggerated striatal 6-fluorodopa uptake, supports the hypothesis that prefrontal cortex dysfunction may lead to dopaminergic transmission abnormalities [4].
A 6-fluorodopa PET study revealed bilateral decreased uptake in the basal ganglia [1].

Analytical, diagnostic and therapeutic context of NSC383033

The positive correlation between clinical outcome and caudate function (i.e., 6-fluorodopa PET scans) suggests a positive influence of the transplantation procedure on the diseased striatum [5].

References

Cyanide-induced parkinsonism: clinical, MRI, and 6-fluorodopa PET studies. Rosenberg, N.L., Myers, J.A., Martin, W.R. Neurology (1989) [Pubmed]
Clinical, 18F-dopa PET, and genetic analysis of an ethnic Chinese kindred with early-onset parkinsonism and parkin gene mutations. Wu, R.M., Shan, D.E., Sun, C.M., Liu, R.S., Hwu, W.L., Tai, C.H., Hussey, J., West, A., Gwinn-Hardy, K., Hardy, J., Chen, J., Farrer, M., Lincoln, S. Mov. Disord. (2002) [Pubmed]
Positron emission tomography after MPTP: observations relating to the cause of Parkinson's disease. Calne, D.B., Langston, J.W., Martin, W.R., Stoessl, A.J., Ruth, T.J., Adam, M.J., Pate, B.D., Schulzer, M. Nature (1985) [Pubmed]
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Meyer-Lindenberg, A., Miletich, R.S., Kohn, P.D., Esposito, G., Carson, R.E., Quarantelli, M., Weinberger, D.R., Berman, K.F. Nat. Neurosci. (2002) [Pubmed]
Treatment of refractory Parkinson's disease with adrenal medullary autografts utilizing two-stage surgery. Petruk, K.C., Wilson, A.F., Schindel, D.R., Witt, N.J., McLean, D.R., McFarland, P.A., Johnston, R.G., McPhee, M.S., Martin, W.R., Calne, D.B. Prog. Brain Res. (1990) [Pubmed]

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