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Chemical Compound Review:

CHEMBL22053 2-methyl-3,4-dihydro-1H- isoquinoline

Synonyms: SureCN98108, AG-E-10922, ANW-66824, CHEBI:126919, AK-95488, ...

Suzuki, K. et al., Naoi, M. et al., Naoi, M. et al.

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High impact information on BRN 0127214

A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion [1].
N-methyl-1,2,3,4-tetrahydroisoquinoline was oxidized to produce N-methyl-isoquinolinium ion by type A and type B monoamine oxidase prepared from human brain synaptosomal mitochondria [2].

Biological context of BRN 0127214

In this study, we report the effects of N-methyl-1,2,3,4-tetrahydroisoquinoline (N-Me-TIQ) and N-methylisoquinolinium ion (N-Me-IQ+) on the mitochondrial electron transport system using mitochondria prepared from mouse brains [3].

Associations of BRN 0127214 with other chemical compounds

Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain [3].

Analytical, diagnostic and therapeutic context of BRN 0127214

Formation of N-methyl-1,2,3,4-tetrahydroisoquinoline (NMTIQ) from TIQ was quantitatively assayed by high-performance liquid chromatography with electrochemical detection [1].

References

A N-methyltransferase in human brain catalyses N-methylation of 1,2,3,4-tetrahydroisoquinoline into N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of a dopaminergic neurotoxin, N-methylisoquinolinium ion. Naoi, M., Matsuura, S., Takahashi, T., Nagatsu, T. Biochem. Biophys. Res. Commun. (1989) [Pubmed]
N-methylated tetrahydroisoquinolines as dopaminergic neurotoxins. Naoi, M., Dostert, P., Yoshida, M., Nagatsu, T. Advances in neurology. (1993) [Pubmed]
Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain. Suzuki, K., Mizuno, Y., Yamauchi, Y., Nagatsu, T., Mitsuo, Y. J. Neurol. Sci. (1992) [Pubmed]

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