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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Electron Transport

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Disease relevance of Electron Transport


Psychiatry related information on Electron Transport


High impact information on Electron Transport


Chemical compound and disease context of Electron Transport


Biological context of Electron Transport


Anatomical context of Electron Transport


Associations of Electron Transport with chemical compounds


Gene context of Electron Transport

  • Progressive respiratory chain deficiency and decreased copy number of mitochondrial DNA were evident in cardiomyocytes lacking Dnaja3 [36].
  • SDHD encodes a mitochondrial respiratory chain protein-the small subunit of cytochrome b in succinate-ubiquinone oxidoreductase (cybS) [37].
  • Uncoupling protein-1 (UCP1) is responsible for this uncoupled state, because it allows proton re-entry into the matrix and thus dissipates the proton gradient generated by the respiratory chain [38].
  • Deletion of YTA10 or YTA12 impairs degradation of non-assembled inner membrane proteins and assembly of respiratory chain complexes [39].
  • These studies provide the first direct evidence that not all LHON lineages--even those associated with a biochemical defect in mitochondrial respiratory chain Complex I--carry a mutation in the ND4 gene [40].

Analytical, diagnostic and therapeutic context of Electron Transport


  1. Deficiency of the reduced nicotinamide adenine dinucleotide dehydrogenase component of complex I of mitochondrial electron transport. Fatal infantile lactic acidosis and hypermetabolism with skeletal-cardiac myopathy and encephalopathy. Hoppel, C.L., Kerr, D.S., Dahms, B., Roessmann, U. J. Clin. Invest. (1987) [Pubmed]
  2. Mitochondria, oxygen free radicals, disease and ageing. Raha, S., Robinson, B.H. Trends Biochem. Sci. (2000) [Pubmed]
  3. Hepatic mitochondrial energy production in rats with chronic iron overload. Bacon, B.R., O'Neill, R., Britton, R.S. Gastroenterology (1993) [Pubmed]
  4. Roles of a conserved arginine residue of DsbB in linking protein disulfide-bond-formation pathway to the respiratory chain of Escherichia coli. Kadokura, H., Bader, M., Tian, H., Bardwell, J.C., Beckwith, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Gimenez-Roqueplo, A.P., Favier, J., Rustin, P., Mourad, J.J., Plouin, P.F., Corvol, P., Rötig, A., Jeunemaitre, X. Am. J. Hum. Genet. (2001) [Pubmed]
  6. Complex I defect in muscle from patients with Huntington's disease. Arenas, J., Campos, Y., Ribacoba, R., Martín, M.A., Rubio, J.C., Ablanedo, P., Cabello, A. Ann. Neurol. (1998) [Pubmed]
  7. Ultrastructural examination of the axillary skin biopsy in the diagnosis of metabolic diseases. Abramovich, C.M., Prayson, R.A., McMahon, J.T., Cohen, B.H. Hum. Pathol. (2001) [Pubmed]
  8. Cholinesterase inhibitor rivastigmine enhance the mitochondrial electron transport chain in lymphocytes of patients with Alzheimer's disease. Casademont, J., Miró, O., Rodriguez-Santiago, B., Viedma, P., Blesa, R., Cardellach, F. J. Neurol. Sci. (2003) [Pubmed]
  9. Hyperthermia increases exercise-induced oxidative stress. McAnulty, S.R., McAnulty, L., Pascoe, D.D., Gropper, S.S., Keith, R.E., Morrow, J.D., Gladden, L.B. International journal of sports medicine. (2005) [Pubmed]
  10. Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases. Gu, M., Owen, A.D., Toffa, S.E., Cooper, J.M., Dexter, D.T., Jenner, P., Marsden, C.D., Schapira, A.H. J. Neurol. Sci. (1998) [Pubmed]
  11. Function and structure of complex II of the respiratory chain. Cecchini, G. Annu. Rev. Biochem. (2003) [Pubmed]
  12. Free radicals in the physiological control of cell function. Dröge, W. Physiol. Rev. (2002) [Pubmed]
  13. Ischemic cell death in brain neurons. Lipton, P. Physiol. Rev. (1999) [Pubmed]
  14. A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure. de Lonlay, P., Valnot, I., Barrientos, A., Gorbatyuk, M., Tzagoloff, A., Taanman, J.W., Benayoun, E., Chrétien, D., Kadhom, N., Lombès, A., de Baulny, H.O., Niaudet, P., Munnich, A., Rustin, P., Rötig, A. Nat. Genet. (2001) [Pubmed]
  15. Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Wang, J., Wilhelmsson, H., Graff, C., Li, H., Oldfors, A., Rustin, P., Brüning, J.C., Kahn, C.R., Clayton, D.A., Barsh, G.S., Thorén, P., Larsson, N.G. Nat. Genet. (1999) [Pubmed]
  16. The lipids of Pneumocystis carinii. Kaneshiro, E.S. Clin. Microbiol. Rev. (1998) [Pubmed]
  17. Postischemic administration of succinate reverses the impairment of oxidative phosphorylation after cardiac ischemia and reperfusion injury. Cairns, C.B., Ferroggiaro, A.A., Walther, J.M., Harken, A.H., Banerjee, A. Circulation (1997) [Pubmed]
  18. Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis. Mecklenburgh, K.I., Walmsley, S.R., Cowburn, A.S., Wiesener, M., Reed, B.J., Upton, P.D., Deighton, J., Greening, A.P., Chilvers, E.R. Blood (2002) [Pubmed]
  19. Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia. Gattermann, N., Retzlaff, S., Wang, Y.L., Hofhaus, G., Heinisch, J., Aul, C., Schneider, W. Blood (1997) [Pubmed]
  20. Leigh syndrome associated with a mutation in the NDUFS7 (PSST) nuclear encoded subunit of complex I. Triepels, R.H., van den Heuvel, L.P., Loeffen, J.L., Buskens, C.A., Smeets, R.J., Rubio Gozalbo, M.E., Budde, S.M., Mariman, E.C., Wijburg, F.A., Barth, P.G., Trijbels, J.M., Smeitink, J.A. Ann. Neurol. (1999) [Pubmed]
  21. The wheat mitochondrial gene for subunit I of the NADH dehydrogenase complex: a trans-splicing model for this gene-in-pieces. Chapdelaine, Y., Bonen, L. Cell (1991) [Pubmed]
  22. The biosynthetic pathway of vitamin C in higher plants. Wheeler, G.L., Jones, M.A., Smirnoff, N. Nature (1998) [Pubmed]
  23. Mitochondria and apoptosis. Green, D.R., Reed, J.C. Science (1998) [Pubmed]
  24. Structure of the Escherichia coli fumarate reductase respiratory complex. Iverson, T.M., Luna-Chavez, C., Cecchini, G., Rees, D.C. Science (1999) [Pubmed]
  25. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Cuzzocrea, S., Riley, D.P., Caputi, A.P., Salvemini, D. Pharmacol. Rev. (2001) [Pubmed]
  26. Prooxidant states and tumor promotion. Cerutti, P.A. Science (1985) [Pubmed]
  27. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Rötig, A., Appelkvist, E.L., Geromel, V., Chretien, D., Kadhom, N., Edery, P., Lebideau, M., Dallner, G., Munnich, A., Ernster, L., Rustin, P. Lancet (2000) [Pubmed]
  28. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Matthews, R.T., Yang, L., Browne, S., Baik, M., Beal, M.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  29. Requirement for coenzyme Q in plasma membrane electron transport. Sun, I.L., Sun, E.E., Crane, F.L., Morré, D.J., Lindgren, A., Löw, H. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  30. Chlororespiration: an adaptation to nitrogen deficiency in Chlamydomonas reinhardtii. Peltier, G., Schmidt, G.W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  31. Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency. Bourgeron, T., Rustin, P., Chretien, D., Birch-Machin, M., Bourgeois, M., Viegas-Péquignot, E., Munnich, A., Rötig, A. Nat. Genet. (1995) [Pubmed]
  32. RNA splicing in Neurospora mitochondria. Characterization of new nuclear mutants with defects in splicing the mitochondrial large rRNA. Bertrand, H., Bridge, P., Collins, R.A., Garriga, G., Lambowitz, A.M. Cell (1982) [Pubmed]
  33. A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes. Ishii, N., Fujii, M., Hartman, P.S., Tsuda, M., Yasuda, K., Senoo-Matsuda, N., Yanase, S., Ayusawa, D., Suzuki, K. Nature (1998) [Pubmed]
  34. Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution. Lancaster, C.R., Kröger, A., Auer, M., Michel, H. Nature (1999) [Pubmed]
  35. Rapid, chloramphenicol-resistant, activation of membrane electron transport on germination of Bacillus spores. Wilkinson, B.J., Ellar, D.J., Scott, I.R., Koncewicz, M.A. Nature (1977) [Pubmed]
  36. A crucial role of mitochondrial Hsp40 in preventing dilated cardiomyopathy. Hayashi, M., Imanaka-Yoshida, K., Yoshida, T., Wood, M., Fearns, C., Tatake, R.J., Lee, J.D. Nat. Med. (2006) [Pubmed]
  37. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Baysal, B.E., Ferrell, R.E., Willett-Brozick, J.E., Lawrence, E.C., Myssiorek, D., Bosch, A., van der Mey, A., Taschner, P.E., Rubinstein, W.S., Myers, E.N., Richard, C.W., Cornelisse, C.J., Devilee, P., Devlin, B. Science (2000) [Pubmed]
  38. Retinoids activate proton transport by the uncoupling proteins UCP1 and UCP2. Rial, E., González-Barroso, M., Fleury, C., Iturrizaga, S., Sanchis, D., Jiménez-Jiménez, J., Ricquier, D., Goubern, M., Bouillaud, F. EMBO J. (1999) [Pubmed]
  39. The formation of respiratory chain complexes in mitochondria is under the proteolytic control of the m-AAA protease. Arlt, H., Steglich, G., Perryman, R., Guiard, B., Neupert, W., Langer, T. EMBO J. (1998) [Pubmed]
  40. An example of Leber hereditary optic neuropathy not involving a mutation in the mitochondrial ND4 gene. Howell, N., McCullough, D. Am. J. Hum. Genet. (1990) [Pubmed]
  41. A novel deficiency of mitochondrial ATPase of nuclear origin. Houstek, J., Klement, P., Floryk, D., Antonická, H., Hermanská, J., Kalous, M., Hansíková, H., Hout'ková, H., Chowdhury, S.K., Rosipal, T., Kmoch, S., Stratilová, L., Zeman, J. Hum. Mol. Genet. (1999) [Pubmed]
  42. Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate. Dugan, L.L., Sensi, S.L., Canzoniero, L.M., Handran, S.D., Rothman, S.M., Lin, T.S., Goldberg, M.P., Choi, D.W. J. Neurosci. (1995) [Pubmed]
  43. Stretch sensitivity of transmembrane mobility of hydrogen peroxide through voids in the bilayer. Role of cardiolipin. Mathai, J.C., Sitaramam, V. J. Biol. Chem. (1994) [Pubmed]
  44. Elucidation of the metabolic fate of glucose in the filamentous fungus Trichoderma reesei using expressed sequence tag (EST) analysis and cDNA microarrays. Chambergo, F.S., Bonaccorsi, E.D., Ferreira, A.J., Ramos, A.S., Ferreira Júnior, J.R., Abrahão-Neto, J., Farah, J.P., El-Dorry, H. J. Biol. Chem. (2002) [Pubmed]
  45. The iron-sulfur protein of cytochrome bc1 complex. Its occurrence in the mitochondrial inner membrane in excess of the amount constituting the complex. Nishikimi, M., Shimomura, Y., Ozawa, T. J. Biol. Chem. (1985) [Pubmed]
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