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Chemical Compound Review:

AG-H-10949 N-(2,6-dioxo-3-piperidyl)-2- phenyl-ethanamide

Synonyms: SureCN2483037, ACMC-20mbwt, AC1L4HDT, CTK5E4752, KB-183949, ...

Tang, Y. et al., Abou-Zeid, L.A. et al., Hendry, L.B. et al., Hendry, L.B. et al., Sidell, N. et al., et al.

Sidell, Tanmahasamut, Ewing, Hendry,

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Disease relevance of NSC377381

3-phenylacetylamino-2,6-piperidinedione inhibition of rat Nb2 lymphoma cell mitogenesis [1].
We previously reported the utility of antineoplaston-A10 (3-phenylacetylamino-2,6-piperidinedione) as an endogenous cancer protector and immune modulator in breast cancer patients (Cancer Lett., 2000, 157, 57) [2].
Antineoplaston A10 (3-phenylacetylamino-2,6-piperidinedione) is an agent derived from human urine which is remarkable for its antineoplastic activity and lack of toxicity [3].

High impact information on NSC377381

3-Phenylacetylamino-2,6-piperidinedione (A10) and related compounds were intercalated into a partially unwound DNA site in a canonical estrogen response element (ERE) [4].
Antineoplaston A-10 (3-phenylacetylamino-2,6-piperidinedione) is the first chemically identified antineoplaston [5].
Antineoplaston A10 (3-phenylacetylamino-2,6-piperidinedione), a peptide analogue originally isolated from human urine, has been demonstrated to fit between base pairs in DNA [6].

Analytical, diagnostic and therapeutic context of NSC377381

This paper reports HPLC methodology for the first successful enantiomeric separations of 3-phenylacetylamino-2,6-piperidinedione (PAP), a naturally occurring peptide derivative used for inhibiting the growth of cancer tissues [7].

References

3-phenylacetylamino-2,6-piperidinedione inhibition of rat Nb2 lymphoma cell mitogenesis. Wood, J.C., Copland, J.A., Muldoon, T.G., Hendry, L.B. Proc. Soc. Exp. Biol. Med. (1991) [Pubmed]
Novel piperidinedione analogs as inhibitors of breast cancer cell growth. Abou-Zeid, L.A., el-Mowafy, A.M., el-Ashmawy, M.B., Hendry, L.B., Abdelal, A.M., Badria, F.A. Arch. Pharm. (Weinheim) (2000) [Pubmed]
Actions of an endogenous antitumorigenic agent on mammary tumor development and modeling analysis of its capacity for interacting with DNA. Hendry, L.B., Muldoon, T.G. J. Steroid Biochem. (1988) [Pubmed]
Transcriptional inhibition of the estrogen response element by antiestrogenic piperidinediones correlates with intercalation into DNA measured by energy calculations. Sidell, N., Tanmahasamut, P., Ewing, D.E., Hendry, L.B. J. Steroid Biochem. Mol. Biol. (2005) [Pubmed]
Immune modulatory potentials of antineoplaston A-10 in breast cancer patients. Badria, F., Mabed, M., El-Awadi, M., Abou-Zeid, L., Al-Nashar, E., Hawas, S. Cancer Lett. (2000) [Pubmed]
Stereochemical modelling studies of the interaction of antineoplaston A10 with DNA. Hendry, L.B., Muldoon, T.G., Burzynski, S.R., Copland, J.A., Lehner, A.F. Drugs under experimental and clinical research. (1987) [Pubmed]
Enantioseparation of 3-phenylacetylamino-2,6-piperidinedione and related chiral compounds. Tang, Y., Reepmeyer, J.C., Revelle, L.K., Wilson, J.A. Journal of chromatography. A. (1996) [Pubmed]

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