Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-J-28182 4-(butylcarbamoylsulfamoyl) benzoic acid

Synonyms: SureCN1478625, AC1Q6VNN, CTK4E8962, AR-1F9306, AR-1F9307, ...

Hansen, L.L. et al., Lee, C.R. et al., Parent, C. et al., Aoki, M. et al.

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High impact information on Carboxytolbutamide

On the other hand, carboxytolbutamide, an inactive metabolite of tolbutamide, had little effect on enzyme phosphorylation and activity [1].
Tolbutamide in plasma and its two major metabolites (hydroxytolbutamide) and carboxytolbutamide in urine were assayed by high-performance liquid chromatography [2].
Tolbutamide is a better CYP2C9 probe than flurbiprofen and losartan, and the 0- to 12-hour amount of 4'-hydroxytolbutamide and carboxytolbutamide is the best urinary measure of its metabolism [3].
An isocratic, high-performance liquid chromatography method has been developed for simultaneous determination of the oral antidiabetic tolbutamide and two of its metabolites, 4-hydroxytolbutamide and carboxytolbutamide, in human plasma and urine [4].

References

Tolbutamide inhibits cAMP-dependent phosphorylation of liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Aoki, M., Kaku, K., Inoue, H., Matsutani, A., Kaneko, T. Diabetes (1992) [Pubmed]
Effect of inflammation on the rabbit hepatic cytochrome P-450 isoenzymes: alterations in the kinetics and dynamics of tolbutamide. Parent, C., Bélanger, P.M., Jutras, L., du Souich, P. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
Tolbutamide, flurbiprofen, and losartan as probes of CYP2C9 activity in humans. Lee, C.R., Pieper, J.A., Frye, R.F., Hinderliter, A.L., Blaisdell, J.A., Goldstein, J.A. Journal of clinical pharmacology. (2003) [Pubmed]
Quantitative determination of tolbutamide and its metabolites in human plasma and urine by high-performance liquid chromatography and UV detection. Hansen, L.L., Brøsen, K. Therapeutic drug monitoring. (1999) [Pubmed]

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