The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Diabetol     1-butyl-3-(4- methylphenyl)sulfonyl-urea

Synonyms: Rastinon, Artosin, Dolipol, Orinase, Diaval, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Orinase


Psychiatry related information on Orinase


High impact information on Orinase


Chemical compound and disease context of Orinase


Biological context of Orinase


Anatomical context of Orinase


Associations of Orinase with other chemical compounds


Gene context of Orinase

  • CYP2C9 activity was significantly (P < or = .005) increased by 38% +/- 35%, as reflected by the tolbutamide urinary metabolic ratio and oral clearance [34].
  • The area under the concentration-time curve ratio of S-nirvanol/S-mephenytoin, an index of CYP2B6 activity, increased 1.9-fold (P <.05) in CYP2C19 poor metabolizers during artemisinin multiple-dose administration, whereas the urinary excretion ratio of hydroxytolbutamide plus carboxytolbutamide/tolbutamide remained constant during the study period [35].
  • RESULTS: An intronic variant of the ABCC8 gene just upstream of exon 16 was a significant determinant of both DI and an analogous index based on acute insulin response to tolbutamide [36].
  • Troleandomycin (40 mumol/L) inhibited hydroxylamine formation at 100 mumol/L dapsone by 50%; diethyldithiocarbamate (150 mumol/L) and tolbutamide (400 mumol/L) inhibited at 5 mumol/L dapsone by 50% and 20%, respectively, suggesting that the low-affinity isozyme is CYP3A4 and the high-affinity isozymes are 2E1 and 2C [37].
  • Hydroxylamine formation correlated strongly with tolbutamide 4-hydroxylation (CYP2C8/9) in HLM (r = 0.76, p < or = 0.004, n = 12) [38].

Analytical, diagnostic and therapeutic context of Orinase


  1. Tolbutamide, smoking, and cardiac arrhythmia. A case report. Poffenbarger, P.L., Scott, J. JAMA (1980) [Pubmed]
  2. Tolbutamide-associated hyponatremia. Lichtenberg, L., Abraira, C. JAMA (1978) [Pubmed]
  3. Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors. Clausen, J.O., Borch-Johnsen, K., Ibsen, H., Bergman, R.N., Hougaard, P., Winther, K., Pedersen, O. J. Clin. Invest. (1996) [Pubmed]
  4. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. Plum, L., Ma, X., Hampel, B., Balthasar, N., Coppari, R., Münzberg, H., Shanabrough, M., Burdakov, D., Rother, E., Janoschek, R., Alber, J., Belgardt, B.F., Koch, L., Seibler, J., Schwenk, F., Fekete, C., Suzuki, A., Mak, T.W., Krone, W., Horvath, T.L., Ashcroft, F.M., Brüning, J.C. J. Clin. Invest. (2006) [Pubmed]
  5. The relative roles of calcium, phosphorus, and parathyroid hormone in glucose- and tolbutamide-mediated insulin release. Harter, H.R., Santiago, J.V., Rutherford, W.E., Slatopolsky, E., Klahr, S. J. Clin. Invest. (1976) [Pubmed]
  6. Relationships between medial hypothalamic alpha 2-receptor binding, norepinephrine, and circulating glucose. Chafetz, M.D., Parko, K., Diaz, S., Leibowitz, S.F. Brain Res. (1986) [Pubmed]
  7. Inotropic effects of tolbutamide in man. Young, J.L., Burr, I.M., Perry, J.M., Nelson, J.H., Nies, A.S. Am. Heart J. (1975) [Pubmed]
  8. Glucose and the insulin-releasing drug tolbutamide attenuate the effects of morphine and angiotensin on alcohol consumption. Grupp, L.A., Hsu, G., Ng, N., Harding, S. Alcohol (1997) [Pubmed]
  9. Potentiation of the pressor response to stress by tolbutamide in dogs. Lee, K.C., Randall, D.C. Integrative physiological and behavioral science : the official journal of the Pavlovian Society. (1993) [Pubmed]
  10. Neuroendocrine conditioning: conditioned feeding after alterations in glucose utilization. Balagura, S., Harrell, L.E. Am. J. Physiol. (1975) [Pubmed]
  11. Serum insulin and growth hormone response patterns in monozygotic twin siblings of patients with juvenile-onset diabetes. Johansen, K., Soeldner, J.S., Gleason, R.E., Gottlieb, M.S., Park, B.N., Kaufmann, R.L., Tan, M.H. N. Engl. J. Med. (1975) [Pubmed]
  12. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D., Ashford, M.L. Nature (1997) [Pubmed]
  13. Tolbutamide pharmacogenetics and the UGDP controversy. Scott, J., Poffenbarger, P.L. JAMA (1979) [Pubmed]
  14. Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. Mashima, H., Ohnishi, H., Wakabayashi, K., Mine, T., Miyagawa, J., Hanafusa, T., Seno, M., Yamada, H., Kojima, I. J. Clin. Invest. (1996) [Pubmed]
  15. Tolbutamide perifusion of rat islets. Sequential changes in calcium, phosphorus, sodium, potassium, and chlorine in single beta cells. Kalkhoff, R.K., Siegesmund, K.A., Dragen, R.F. J. Clin. Invest. (1983) [Pubmed]
  16. Plasma C-peptide and diagnosis of factitious hyperinsulinism. Study of an insulin-dependent diabetic patient with "spontaneous" hypoglycemia. Couropmitree, C., Freinkel, N., Nagel, T.C., Horwitz, D.L., Rubenstein, A.H., Metzger, B., Rubenstein, A.H., Hahnel, R. Ann. Intern. Med. (1975) [Pubmed]
  17. Sulfonylureas, ATP-sensitive K+ channels, and cellular K+ loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle. Venkatesh, N., Lamp, S.T., Weiss, J.N. Circ. Res. (1991) [Pubmed]
  18. Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin-dependent diabetes mellitus. Coniff, R.F., Shapiro, J.A., Seaton, T.B., Bray, G.A. Am. J. Med. (1995) [Pubmed]
  19. Effects of sulfonylureas on histochemical and ultracytochemical calcium distribution in B-cells of mice. Klöppel, G., Schäfer, H.J. Diabetologia (1976) [Pubmed]
  20. Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells. Vigneri, R., Pezzino, V., Wong, K.Y., Goldfine, I.D. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  21. Nuclear KATP channels trigger nuclear Ca(2+) transients that modulate nuclear function. Quesada, I., Rovira, J.M., Martin, F., Roche, E., Nadal, A., Soria, B. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  22. Oscillations in KATP channel activity promote oscillations in cytoplasmic free Ca2+ concentration in the pancreatic beta cell. Larsson, O., Kindmark, H., Brandstrom, R., Fredholm, B., Berggren, P.O. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  23. The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein. Barg, S., Renström, E., Berggren, P.O., Bertorello, A., Bokvist, K., Braun, M., Eliasson, L., Holmes, W.E., Köhler, M., Rorsman, P., Thévenod, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  24. The effects of tolbutamide on the myocardium in experimental diabetes. Wu, C.F., Haider, B., Ahmed, S.S., Oldewurtel, H.A., Lyons, M.M., Regan, T.J. Circulation (1977) [Pubmed]
  25. Release of immunoreactive somatostatin from the pancreas in response to glucose, amino acids, pancreozymin-cholecystokinin, and tolbutamide. Ipp, E., Dobbs, R.E., Arimura, A., Vale, W., Harris, V., Unger, R.H. J. Clin. Invest. (1977) [Pubmed]
  26. The sulphonylurea receptor may be an ATP-sensitive potassium channel. Sturgess, N.C., Ashford, M.L., Cook, D.L., Hales, C.N. Lancet (1985) [Pubmed]
  27. Improvement in insulin secretion in diabetes after diazoxide. Greenwood, R.H., Mahler, R.F., Hales, C.N. Lancet (1976) [Pubmed]
  28. Differential regulation of two distinct glucose transporter species expressed in 3T3-L1 adipocytes: effect of chronic insulin and tolbutamide treatment. Tordjman, K.M., Leingang, K.A., James, D.E., Mueckler, M.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  29. Adaptations of alpha2- and beta-cells of rat and mouse pancreatic islets to starvation, to refeeding after starvation, and to obesity. Matschinsky, F.M., Rujanavech, C., Pagliara, A., Norfleet, W.T. J. Clin. Invest. (1980) [Pubmed]
  30. Evidence for the existence of a sulfonylurea-receptor-like protein in plants: modulation of stomatal movements and guard cell potassium channels by sulfonylureas and potassium channel openers. Leonhardt, N., Marin, E., Vavasseur, A., Forestier, C. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  31. Endogenous adenosine mediates the presynaptic inhibition induced by aglycemia at corticostriatal synapses. Calabresi, P., Centonze, D., Pisani, A., Bernardi, G. J. Neurosci. (1997) [Pubmed]
  32. Regulation of a potassium conductance in rat midbrain dopamine neurons by intracellular adenosine triphosphate (ATP) and the sulfonylureas tolbutamide and glibenclamide. Stanford, I.M., Lacey, M.G. J. Neurosci. (1995) [Pubmed]
  33. Cyclic nucleotides in pancreatic islets. Tolbutamide- and arginine-induced insulin release. Charles, M.A., Lawecki, J., Steiner, A.L., Grodsky, G.M. Diabetes (1976) [Pubmed]
  34. In vivo effects of interleukin-10 on human cytochrome P450 activity. Gorski, J.C., Hall, S.D., Becker, P., Affrime, M.B., Cutler, D.L., Haehner-Daniels, B. Clin. Pharmacol. Ther. (2000) [Pubmed]
  35. Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9. Simonsson, U.S., Jansson, B., Hai, T.N., Huong, D.X., Tybring, G., Ashton, M. Clin. Pharmacol. Ther. (2003) [Pubmed]
  36. Role of common sequence variants in insulin secretion in familial type 2 diabetic kindreds: the sulfonylurea receptor, glucokinase, and hepatocyte nuclear factor 1alpha genes. Elbein, S.C., Sun, J., Scroggin, E., Teng, K., Hasstedt, S.J. Diabetes Care (2001) [Pubmed]
  37. Metabolism of dapsone to its hydroxylamine by CYP2E1 in vitro and in vivo. Mitra, A.K., Thummel, K.E., Kalhorn, T.F., Kharasch, E.D., Unadkat, J.D., Slattery, J.T. Clin. Pharmacol. Ther. (1995) [Pubmed]
  38. Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Winter, H.R., Unadkat, J.D. Drug Metab. Dispos. (2005) [Pubmed]
  39. Comparative diagnostic value of the calcium-pentagastrin test versus the tolbutamide test in a patient with a somatostatinoma. Budmiger, H., Bühler, H., Häcki, W., Stamm, B., Streuli, R., Ammann, R. Gastroenterology (1987) [Pubmed]
  40. Method of insulin administration has no effect on insulin sensitivity estimates from the insulin-modified minimal model protocol. Saad, M.F., Steil, G.M., Riad-Gabriel, M., Khan, A., Sharma, A., Boyadjian, R., Jinagouda, S.D., Bergman, R.N. Diabetes (1997) [Pubmed]
  41. Glucose-sensing in glucagon-like peptide-1-secreting cells. Reimann, F., Gribble, F.M. Diabetes (2002) [Pubmed]
  42. Tolbutamide stimulates fructose-2, 6-bisphosphate formation in perfused rat liver. Matsutani, A., Kaku, K., Kaneko, T. Diabetes (1984) [Pubmed]
WikiGenes - Universities