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Chemical Compound Review

Diabetol     1-butyl-3-(4- methylphenyl)sulfonyl-urea

Synonyms: Rastinon, Artosin, Dolipol, Orinase, Diaval, ...
 
 
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Disease relevance of Orinase

 

Psychiatry related information on Orinase

 

High impact information on Orinase

 

Chemical compound and disease context of Orinase

 

Biological context of Orinase

 

Anatomical context of Orinase

 

Associations of Orinase with other chemical compounds

 

Gene context of Orinase

  • CYP2C9 activity was significantly (P < or = .005) increased by 38% +/- 35%, as reflected by the tolbutamide urinary metabolic ratio and oral clearance [34].
  • The area under the concentration-time curve ratio of S-nirvanol/S-mephenytoin, an index of CYP2B6 activity, increased 1.9-fold (P <.05) in CYP2C19 poor metabolizers during artemisinin multiple-dose administration, whereas the urinary excretion ratio of hydroxytolbutamide plus carboxytolbutamide/tolbutamide remained constant during the study period [35].
  • RESULTS: An intronic variant of the ABCC8 gene just upstream of exon 16 was a significant determinant of both DI and an analogous index based on acute insulin response to tolbutamide [36].
  • Troleandomycin (40 mumol/L) inhibited hydroxylamine formation at 100 mumol/L dapsone by 50%; diethyldithiocarbamate (150 mumol/L) and tolbutamide (400 mumol/L) inhibited at 5 mumol/L dapsone by 50% and 20%, respectively, suggesting that the low-affinity isozyme is CYP3A4 and the high-affinity isozymes are 2E1 and 2C [37].
  • Hydroxylamine formation correlated strongly with tolbutamide 4-hydroxylation (CYP2C8/9) in HLM (r = 0.76, p < or = 0.004, n = 12) [38].
 

Analytical, diagnostic and therapeutic context of Orinase

References

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