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Chemical Compound Review

Flugalin     2-(3-fluoro-4-phenyl- phenyl)propanoic acid

Synonyms: Cebutid, Ocuflur, Ansaid, Froben, Ocufen, ...
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Disease relevance of Ansaid


Psychiatry related information on Ansaid


High impact information on Ansaid


Chemical compound and disease context of Ansaid


Biological context of Ansaid


Anatomical context of Ansaid


Associations of Ansaid with other chemical compounds

  • The endothelium-dependent relaxation of canine arteries remains intact after treatment with cyclooxygenase inhibitors (indomethacin and flurbiprofen), and this argues against mediation by prostaglandins [22].
  • The lipoxygenase inhibitor nordihydroguaiaretic acid had almost no effect in decreasing the response, while flurbiprofen, a cyclooxygenase inhibitor was very effective at 10(-6) M [23].
  • Hp-induced PGE2 formation was abolished by indomethacin and flurbiprofen, whereas the stimulation of 45Ca release was only partially reduced [24].
  • Km values for arachidonate (8 microM) and ID50 values for reversible inhibition by the cyclooxygenase inhibitors, flurbiprofen (5 microM), flufenamate (20 microM), and aspirin (20 mM), were also the same for both native and mutant PGG/H synthases; however, only the native enzyme was irreversibly inactivated by aspirin [25].
  • From the crystal structure of sheep PGHS-1, it has been proposed that the carboxylic acid group of flurbiprofen is located in a favorable position for interacting with the arginine 120 residue of PGHS-1 (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249) [26].

Gene context of Ansaid


Analytical, diagnostic and therapeutic context of Ansaid


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  32. The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution. Wester, M.R., Yano, J.K., Schoch, G.A., Yang, C., Griffin, K.J., Stout, C.D., Johnson, E.F. J. Biol. Chem. (2004) [Pubmed]
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